The Prospect of Creating Medicines Based on Selenium Nanoparticles (Review)

Abstract

Introduction. The prospects of using nanoparticles in the production of medicines are widely discussed in the literature. In 2018 alone, the quantity of registration certificates issued by national regulators for medicines that use nanoparticles in one form or another is around forty. Most of them are medicines based on liposomes, polymers, iron oxides, micelles. So far, no registration certificates have been issued for selenium nanoparticles. One of the reasons for this situation in this area, from our point of view, is that the mechanisms of interaction of nanoparticles with cells are not sufficiently studied. The lack of basic research in this area is one of the main obstacles to the development of new-generation drugs based on nanoparticles.Text. This review is devoted to the analysis of scientific data on the interaction of selenium nanoparticles with different types of cells. The article discusses the biological properties of selenium and its role in cell metabolism. Data on the cytotoxic effect of selenium nanoparticles on various cell cultures are presented. Methods of preparation of nanoparticles and methods for studying the interaction of nanoparticles with cell cultures are described.Conclusion. Analysis of the literature data allows us to draw conclusions about the relevance of research on the interaction of selenium nanoparticles with living cells. This is necessary to determine the mechanisms of selenium nanoparticles absorption, study their cytotoxic and / or cytostatic action, and distribution in cells. Investigation of the biological interaction of selenium nanoparticles with tumor and normal cells will determine the most informative methods for registering and quantifying their antitumor activity, which is relevant for the development of new drugs to treat cancer.

Efficacy Evaluation of a Case-Specific Approach for Surgical Treatment of Inicisional Ventral Hernia

“…In [ 1 5 ], the authors point out that the surgical intervention is performed by separating the components by posterior opening or using an endoscopic approach, which shows good results and eliminates the risk of recurrences and blood loss, but this tactic involves massive surgical intervention and has contraindications for certain categories of patients, for example, the geriatrics. The retro rectus method with the polypropylene mesh, proposed in [ 5 18 19 ] for restoring the midline of the anterior abdominal wall with IVH, according to the results presented by the authors, is safe and characterized by minimal complications and recurrences for medium-sized hernias (6–13%). For the recovery of large sizes hernias, the method is recognized as the procedure of choice.…”

“…The structure of the wound complications mainly indicates: suppuration, the wound edges divergence, seroma, inflammatory infiltrate, long-term lymphorrhea, ligature fistulas, and wound edges necrosis [ 14 15 16 17 ]. The “new” complications, those caused exclusively by synthetic mesh prostheses, are the prosthesis migrating into the lumen of the hollow organ; intestinal fistula induced by trauma to the intestinal wall; prosthetic cyst; adhesive intestinal obstruction (seen when the intestine adheres to the prosthesis); and mesh rupture with the recurrent hernia or infringement of the hollow organs [ 14 18 19 ]. However, data collected about these complications are contradictory.…”

Influence of Professional Teeth Whitening on Oral Hygiene

“…We have found just a few publications dedicated to long-term influence of professional bleaching on individual oral hygiene. For example, Skorinova et al [ 28 ] in 2020 estimated results of home dental bleaching and found no significant differences in hygienic index in the estimated and control groups 6 months after the procedure. Fernández et al [ 29 ] were estimating psycho-emotional status of patients for 9 months after professional bleaching and, on the contrary, noted that bleaching had good influence on esthetic self-estimation of smile and motivated patients in maintaining health of oral cavity.…”

Mesenteric Vessel Thrombosis Treatment Experience

“…The main symptoms are severe pain (absent in 20% of cases) in the abdomen [4], [10], nausea (93%), vomiting (80%), diarrhea (48%), and general weakness [11]. AMI can be unclear or proceed under the guise of other diseases of the abdominal organs so the diagnosis of this pathology is very difficult [12]. The long-term pain without obvious signs of surgical pathology is a reason to suspect mesenteric vessels thrombosis [13].…”