The proportion of women with central sensitivity syndrome in gynecology outpatient clinics (GOPDs)

Vij, Monika; Davies, Anthony; Dua, Anu; Freeman, Robert

doi:10.1007/s00192-018-3709-0

Cited by 7 publications

(8 citation statements)

References 18 publications

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“…15 A small study evaluated women presenting to a general gynaecology clinic using the CSI and found the prevalence of QPCS to be 37%. 16 Our study found that the prevalence of QPCS was 75%, significantly higher than these comparative studies, indicating a strong association between QPCS and PP. This finding indicates that gynaecologists working in the area of PP must be aware of CS as a significant contributor to pain and be able to work in a multidisciplinary setting.…”

Section: Discussioncontrasting

confidence: 61%

Central sensitisation in pelvic pain: A cohort study

Ryan

Healey

Cheng

et al. 2022

Aust NZ J Obst Gynaeco

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Background Central sensitisation (CS) leads to pain amplification and impacts on the management of pelvic pain (PP). Identification of CS in patients with PP may provide additional treatment pathways and improve patient outcomes. Aims The aims are to quantify the prevalence of questionnaire‐predicted CS (QPCS) in patients presenting with PP and investigate associations between QPCS and clinical variables. Materials and methods This was an observational, cross‐sectional study. Subjects with PP completed a questionnaire comprising four validated tools: the Central Sensitisation Inventory (CSI) for QPCS, Pain Catastrophising Scale for Catastrophising Trait, Bladder Pain/Interstitial Cystitis Symptom Score for bladder pain syndrome (BPS) and the Rome IV criteria for irritable bowel syndrome (IBS). Results One hundred and eleven women were enrolled in the study; 74.8% (n = 83) had a CSI score of >40, indicating the presence of QPCS. Subjects with QPCS were more likely to screen positive for catastrophising trait (odds ratio (OR) 3.57, 95% CI 1.19–10.76, P = 0.02), BPS (OR 11.77, 95% CI 2.13–64.89, P = 0.005) and IBS (OR 2.6, 95% CI 1.05–6.43, P = 0.04). They were more likely to experience pain for more than two years (OR 4.98, 95% CI 1.94–12.82, P = 0.001) and other pain symptoms involving bladder (OR 9.87, 95% CI 2.52–38.67, P = 0.001), bowel (OR 3.13, 95% CI 1.31–7.48, P = 0.01), back (OR 4.17, 95% CI 1.66–10.51, P = 0.002) and vulva (OR 3.61, 95% CI 1.21–10.82, P = 0.02). They also had higher previous diagnoses of mental health disorder (OR 3.5, 95% CI 1.5–8.4, P = 0.005) or IBS (OR 8.9, 95% CI 1.6–49.1, P = 0.01). Conclusions QPCS occurs frequently in patients with PP, and subjects with QPCS experience more prolonged and complex pain.

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Section: Discussioncontrasting

confidence: 61%

Central sensitisation in pelvic pain: A cohort study

Ryan

Healey

Cheng

et al. 2022

Aust NZ J Obst Gynaeco

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“…In 2022, Orr et al17 applied the CSI to 355 patients with endometriosis and determined that patients who scored >40 (range: 0 to 100) were more likely to have 3 or more central sensitization syndromes or pain-related conditions in addition to their diagnosis of endometriosis, as well as higher pain scores. The CSI was similarly applied to gynecologic patients seeking outpatient care with similar findings 18…”

Section: Introductionmentioning

confidence: 66%

Persistent Pelvic Pain in Patients With Endometriosis

Green

Burnett

Famuyide

2022

Clinical Obstetrics &Amp; Gynecology

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As our understanding of chronic pain conditions, including endometriosis-related pain and chronic pelvic pain evolves, the evaluation and management of patients should reflect our increasing appreciation of the role of central sensitization, comorbid conditions and biopsychosocial factors on the pain experience and treatment outcomes. This review provides a systematic approach to persistent pain in patients with endometriosis. Expanding the evaluation and treatment of endometriosis-related pain by all health care providers could limit unnecessary surgical interventions and best meet our patient's needs.

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“…Psychological factors are acknowledged to play a key role in the development of central sensitivity syndromes (CSS) 48 which have been identified in 32% of women with POP attending a gynecology clinic 49 . Furthermore, CSS, as measured by the central sensitivity inventory 50 were found to be predictors of poor outcomes in women undergoing prolapse surgery 19 .…”

Section: Discussionmentioning

confidence: 99%

The relationship between symptom severity, bother and psychological factors in women with pelvic organ prolapse: A cross‐sectional observational study

Drage

Aghera

MacKellar

et al. 2021

Neurourology and Urodynamics

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Aim: The primary aim is to explore the relationship between symptom severity and prolapse bother in women with pelvic organ prolapse (POP). The secondary aim is to determine the association between psychological variables and prolapse bother. Methods: A cross-sectional observational study was conducted via online surveys assessing POP bother (visual analog scale for bother), POP symptom severity (International Consultation on Incontinence Questionnaire-Vaginal Symptoms), and psychological measures of depression and anxiety (Kessler psychological distress scale [K-10]), catastrophizing (modified pain catastrophizing scale [mPCS]), and self-efficacy (modified pain self-efficacy questionnaire [mPSEQ]) in women with self-reported POP. Symptom severity, bother and psychological variables were analyzed using linear regression.Results: Seventy-six women with a mean (SD) age of 42.8 (14.57) years were included in analysis. A moderate to strong positive linear relationship (R 2 = 0.449, p < 0.001) was found between symptom severity and POP bother.Prolapse bother and psychological variables were moderately correlated, where increased K-10 scores (R 2 = 0.230, p = 0.001), higher mPCS scores (R 2 = 0.460, p < 0.001), and lower mPSEQ scores (R 2 = 0.460, p < 0.001) were associated with increased POP bother. Moderate and severe catastrophizing was associated with significantly higher POP bother, with mean POP bother scores of 7.861 ± 0.45 (p < 0.001) and 8.652 ± 0.45 (p < 0.001), respectively. Conclusion: A moderate positive relationship between POP bother and symptom severity was found, with greater psychological distress and lower self-efficacy associated with increasing POP bother. Women presenting with POP should be screened for psychological factors to guide management.

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The proportion of women with central sensitivity syndrome in gynecology outpatient clinics (GOPDs)

Cited by 7 publications

References 18 publications

Central sensitisation in pelvic pain: A cohort study

Central sensitisation in pelvic pain: A cohort study

Persistent Pelvic Pain in Patients With Endometriosis

The relationship between symptom severity, bother and psychological factors in women with pelvic organ prolapse: A cross‐sectional observational study

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