The Proportion of Tumour-Stroma in Metastatic Lymph Nodes is An Accurately Prognostic Indicator of Poor Survival for Advanced-Stage Colon Cancers

Zengin, Mehmet; Benek, Suat

doi:10.1007/s12253-020-00877-1

Cited by 3 publications

(10 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After reviewing the titles and abstracts, we excluded another 523 articles, leaving 132 articles for further assessment. Consequently,15 studies involving 5048 patients met the criteria for inclusion and were included in the meta-analysis ( 12 – 15 , 27 – 37 ) ( Figure 1 ) . The number of patients in each study ranged from 65 to 1212.…”

Section: Resultsmentioning

confidence: 99%

“…Among these 15 studies, 12 studies reported DFS as survival outcome ( 12 – 15 , 27 – 32 , 35 , 37 ), four reported CSS ( 14 , 33 , 34 , 36 ) and eight reported OS ( 13 , 15 , 27 , 28 , 31 , 32 , 35 , 37 ). Thirteen of the 15 articles had set the cutoff at 50% to divide patients into low-stroma and high-stroma groups ( 12 , 14 , 15 , 27 – 35 , 37 ), while one at 47% ( 36 ) and the other at 68% ( 13 ). The NOS scores of all studies included were > 6 in terms of methodological consistency.…”

Section: Resultsmentioning

confidence: 99%

“…Geessink et al estimated stroma ratio by both visual and automethods ( 14), we included the results from the visual method to reduce heterogeneity among the included literature. West et al and Zengin et al defined rich-stroma as stroma more than 47% and 68%, respectively (27,36), while the rest included studies all set the cutoff point at 50%. Despite the above problems, Sensitivity analysis showed that no individual study had statistically significant influence on the pooled results.…”

Section: Discussionmentioning

confidence: 99%

“…and Zengin et al. defined rich-stroma as stroma more than 47% and 68%, respectively ( 27 , 36 ), while the rest included studies all set the cutoff point at 50%. Despite the above problems, Sensitivity analysis showed that no individual study had statistically significant influence on the pooled results.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Prognostic Value of Tumor-Stroma Ratio in Rectal Cancer: A Systematic Review and Meta-analysis

et al. 2021

View full text Add to dashboard Cite

BackgroundTumor-stroma ratio (TSR) is a promising new prognostic predictor for patients with rectal cancer (RC). Although several studies focused on this pathologic feature, results from those studies were still inconsistent.MethodsThis research aimed to estimate the prognostic values of TSR for RC. A search of PubMed, EMBASE, and Web of Science was carried out. A meta-analysis was performed on disease-free survival, cancer-specific survival, and overall survival in patients with RC.ResultsThe literature search generated 1,072 possible studies, of which a total of 15 studies, involving a total of 5,408 patients, were eventually included in the meta-analysis. Thirteen of the 15 articles set the cutoff for the ratio of stroma at 50%, dividing patients into low-stroma and high-stroma groups. Low TSR (rich-stroma) was significantly associated with poorer survival outcome. (DFS: HR 1.54, 95% CI 1.32–1.79; OS: HR 1.52 95% CI 1.34–1.73; CSS: HR 2.05 95% CI 1.52–2.77).ConclusionPresent data support TSR to be a risk predictor for poor prognosis in RC patients.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Prognostic Value of Tumor-Stroma Ratio in Rectal Cancer: A Systematic Review and Meta-analysis

et al. 2021

View full text Add to dashboard Cite

show abstract

“…All the studies we included had reported the data using a cutoff value of 0.5 (50%) or more for classifying the high stroma or low TSR value. One study was reported from China (16), one from Turkey (17), three from the United Kingdom (5,18,19), seven from the Netherlands (20)(21)(22)(23)(24)(25)(26), one from Poland (27), and two from Denmark (28). Five studies used the retrospective study design for their study (Table 1).…”

Section: Study Characteristicsmentioning

confidence: 99%

Impact of Tumor–Stroma Ratio on the Prognosis of Colorectal Cancer: A Systematic Review

et al. 2021

View full text Add to dashboard Cite

BackgroundIt is critical to develop a reliable and cost-effective prognostic tool for colorectal cancer (CRC) stratification and treatment optimization. Tumor–stroma ratio (TSR) may be a promising indicator of poor prognosis in CRC patients. As a result, we conducted a systematic review on the predictive value of TSR in CRC.MethodsThis study was carried out according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guideline. An electronic search was completed using commonly used databases PubMed, CENTRAL, Cochrane Central Register of Controlled Trials, and Google scholar till the last search up to May 30, 2021. STATA version 13 was used to analyze the data.ResultsA total of 13 studies [(12 for disease-free survival (DFS) and nine studies for overall survival (OS)] involving 4,857 patients met the inclusion criteria for the systematic review in the present study. In individuals with stage II CRC, stage III CRC, or mixed stage CRC, we observed a significantly higher pooled hazard ratio (HR) in those with a low TSR/greater stromal content (HR, 1.54; 95% CI: 1.20 to 1.88), (HR, 1.90; 95% CI: 1.35 to 2.45), and (HR, 1.70; 95% CI: 1.45 to 1.95), respectively, for predicting DFS. We found that a low TSR ratio had a statistically significant predictive relevance for stage II (HR, 1.43; 95% CI: 1.09 to 1.77) and mixed stages of CRC (HR, 1.65; 95% CI: 1.31 to 2.0) for outcome OS.ConclusionIn patients with CRC, low TSR was found to be a prognostic factor for a worse prognosis (DFS and OS).

show abstract

DataSheet_1.docx

View full text Add to dashboard Cite

The Proportion of Tumour-Stroma in Metastatic Lymph Nodes is An Accurately Prognostic Indicator of Poor Survival for Advanced-Stage Colon Cancers

Cited by 3 publications

References 25 publications

Prognostic Value of Tumor-Stroma Ratio in Rectal Cancer: A Systematic Review and Meta-analysis

Prognostic Value of Tumor-Stroma Ratio in Rectal Cancer: A Systematic Review and Meta-analysis

Impact of Tumor–Stroma Ratio on the Prognosis of Colorectal Cancer: A Systematic Review

DataSheet_1.docx

Contact Info

Product

Resources

About