The Proportion of Nervonic Acid in Serum Lipids is Associated with Serum Plasmalogen Levels and Metabolic Syndrome

Yamazaki, Yuya; Kondo, Kazuya; Maeba, Ryouta; Nishimukai, Megumi; Nezu, Toru; Hara, Hiroshi

doi:10.5650/jos.ess13226

Cited by 59 publications

(50 citation statements)

References 35 publications

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“…Thus, it seems the plasmalogen status does not indicate any defective function in our rat model, while plasmalogens are crucial, for instance, for Schwann cell development and differentiation [59] or as neuroprotective against apoptosis [60], although the role of the alkenyl species remains poorly documented and requires detailed study. Yamazaki showed a structural evolution in plasmenylcholine and plasmenylethanolamine in metabolic syndrome [61]. Kaddurah-Daouk also demonstrated a modulation in the fatty aldehyde structure during the psychotic episode of schizophrenia [62].…”

Section: Discussionmentioning

confidence: 97%

Impact of a Standard Rodent Chow Diet on Tissue n‐6 Fatty Acids, Δ9‐Desaturation Index, and Plasmalogen Mass in Rats Fed for One Year

Pédrono

Boulier-Monthéan

Catheline

et al. 2015

Lipids

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Although many studies focus on senescence mechanisms, few habitually consider age as a biological parameter. Considering the effect of interactions between food and age on metabolism, here we depict the lipid framework of 12 tissues isolated from Sprague-Dawley rats fed standard rodent chow over 1 year, an age below which animals are commonly studied. The aim is to define relevant markers of lipid metabolism influenced by age in performing a fatty acid (FA) and dimethylacetal profile from total lipids. First, our results confirm impregnation of adipose and muscular tissues with medium-chain FA derived from maternal milk during early infancy. Secondly, when animals were switched to standard croquettes, tissues were remarkably enriched in n-6 FA and especially 18:2n-6. This impregnation over time was coupled with a decrease of the desaturation index and correlated with lower activities of hepatic Δ5- and Δ6-desaturases. In parallel, we emphasize the singular status of testis, where 22:5n-6, 24:4n-6, and 24:5n-6 were exceptionally accumulated with growth. Thirdly, 18:1n-7, usually found as a discrete FA, greatly accrued over the course of time, mostly in liver and coupled with Δ9-desaturase expression. Fourthly, skeletal muscle was characterized by a surprising enrichment of 22:6n-3 in adults, which tended to decline in older rats. Finally, plasmalogen-derived dimethylacetals were specifically abundant in brain, erythrocytes, lung, and heart. Most notably, a shift in the fatty aldehyde moiety was observed, especially in brain and erythrocytes, implying that red blood cell analysis could be a good indicator of brain plasmalogens.

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Section: Discussionmentioning

confidence: 97%

Impact of a Standard Rodent Chow Diet on Tissue n‐6 Fatty Acids, Δ9‐Desaturation Index, and Plasmalogen Mass in Rats Fed for One Year

Pédrono

Boulier-Monthéan

Catheline

et al. 2015

Lipids

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“…We show decreased nervonic acid, increased DGLA, and increased palmitoleic acid incorporation into PPLs of overweight and obese individuals. Previously, decreased nervonic acid and increased palmitoleic acid in PPLs has been documented in metabolic syndrome (MetS) [6, 24]. Compared to lean participants, obese individuals had significantly increased WC, leptin, C-peptide, MCP-1, and TNF-α, and also significantly decreased adiponectin.…”

Section: Discussionmentioning

confidence: 99%

Plasma phospholipids, non-esterified plasma polyunsaturated fatty acids and oxylipids are associated with BMI

Pickens

Sordillo

Comstock

et al. 2015

Prostaglandins, Leukotrienes and Essential Fatty Acids

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The obese lipid profile is associated with increased free fatty acids and triacylglycerides. Currently, little is known about the plasma lipid species associated with obesity. In this study, we compared plasma lipid fatty acid (FA) profiles as a function of BMI. Profiling phospholipid (PL) FAs and their respective oxylipids could predict which obese individuals are more likely to suffer from diseases associated with chronic inflammation or oxidative stress. We investigated the relationship between BMI and plasma PL (PPL) FA composition in 126 men using a quantitative gas chromatography analysis. BMI was inversely associated with both PPL nervonic and linoleic acid (LA) but was positively associated with both dihomo-γ-linolenic and palmitoleic acid. Compared to lean individuals, obese participants were more likely to have ω-6 FAs, except arachidonic acid and LA, incorporated into PPLs. Obese participants were less likely to have EPA and DHA incorporated into PPLs compared to lean participants. Non-esterified plasma PUFA and oxylipid analysis showed ω-6 oxylipids were more abundant in the obese plasma pool. These ω-6 oxylipids are associated with increased angiogenesis (i.e. epoxyeicosatrienoates), reactive oxygen species (i.e. 9-hydroxyeicosatetraenoate), and inflammation resolution (i.e. Lipoxin A4). In summary, BMI is directly associated with specific PPL FA and increased ω-6 oxylipids.

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“…Although physiological function of circulating plasmalogen is not well elucidated, plasma concentration of plasmalogen is reported to be reduced in Alzheimer disease 16) , metabolic syndrome 17) and inflammatory bowel disease 18) . These reports imply that systemic or local inflammation is deeply involved in the metabolism of plasmalogens, and that plasmalogen may play a protective role against persistent inflammation.…”

Section: Plasma Concentration Of Plasmalogenmentioning

confidence: 99%

【Original Contribution】 Plasma and Erythrocyte Membrane Plasmalogen Diminished in Severe Atherosclerotic Patients Undergoing Endovascular Therapy

et al. 2017

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The Proportion of Nervonic Acid in Serum Lipids is Associated with Serum Plasmalogen Levels and Metabolic Syndrome

Cited by 59 publications

References 35 publications

Impact of a Standard Rodent Chow Diet on Tissue n‐6 Fatty Acids, Δ9‐Desaturation Index, and Plasmalogen Mass in Rats Fed for One Year

Impact of a Standard Rodent Chow Diet on Tissue n‐6 Fatty Acids, Δ9‐Desaturation Index, and Plasmalogen Mass in Rats Fed for One Year

Plasma phospholipids, non-esterified plasma polyunsaturated fatty acids and oxylipids are associated with BMI

【Original Contribution】 Plasma and Erythrocyte Membrane Plasmalogen Diminished in Severe Atherosclerotic Patients Undergoing Endovascular Therapy

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