THE PROPHYLAXIS OF IRON-DEFICIENCY ANqMIA IN PREGNANCY

Kerr, DavidN.S.; Davidson, Stanley

doi:10.1016/s0140-6736(58)91281-9

Cited by 51 publications

(28 citation statements)

References 3 publications

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“…Previously, high doses of ferrous iron (100–200 mg/day) were used in pregnancy [1, 5]. Subsequent studies have shown that lower doses of iron are adequate to prevent iron deficiency [2, 9].…”

Section: Discussionmentioning

confidence: 99%

“…Kerr and Davidson [5] randomized pregnant women to iron prophylaxis with 105 mg of elemental iron (in three divided doses either as ferrous sulfate, n = 81, or ferrous gluconate, n = 88) and compared the results with those of a control group (n = 159) taking placebo tablets containing lactose. The tablets were to be taken after meals.…”

Section: Discussionmentioning

confidence: 99%

“…The tablets were to be taken after meals. There was no significant difference among the three groups with respect to gastrointestinal discomfort [5]. The same authors [11] performed a subsequent randomized, placebo-controlled study with a similar design in 93 fertile, non-pregnant women focusing on gastrointestinal side effects (nausea, vomiting, pyrosis, abdominal discomfort, constipation or diarrhea).…”

Section: Discussionmentioning

confidence: 99%

“…Is this belief based on a myth or is it based on reality? There exist few randomized, controlled studies of the potential side effects of oral iron supplementation in pregnancy [5]. The aim of the present randomized and controlled study was to assess the frequency of gastrointestinal side effects of iron prophylaxis during pregnancy in relation to various doses of ferrous iron, ranging from 20 to 80 mg/day.…”

Section: Introductionmentioning

confidence: 99%

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Side Effects of Oral Iron Prophylaxis in Pregnancy – Myth or Reality?

et al. 2006

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Background: It is a common belief among women that iron compounds have unpleasant gastrointestinal side effects. Objective: To assess the gastrointestinal side effects of iron prophylaxis in pregnancy. Methods: A randomized, double-blind study comprising 404 healthy pregnant women allocated to four groups taking ferrous iron supplement (as fumarate) in doses of 20 (n = 99), 40 (n = 100), 60 (n = 102) and 80 mg (n = 103) daily from 18 weeks of gestation to delivery. Iron supplement was predominantly taken at bedtime. Gastrointestinal symptoms (nausea, vomiting, epigastric pain, eructation, pyrosis, meteorism, borborygmi, colic pain, flatulence, constipation, thin feces, diarrhea), black feces, and use of laxatives were recorded by interview at 18, 32 and 39 weeks of gestation. Results: The frequencies of gastrointestinal symptoms were not significantly different in the four iron supplement groups either at inclusion or at 32 and 39 weeks of gestation and thus not related to the iron dose. Conclusion: This study shows that a supplement of 20–80 mg ferrous iron (as fumarate), taken between meals, has no clinically significant gastrointestinal side effects. The implementation of iron prophylaxis to pregnant women should not be compromised by undue concern of non-existing side effects.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Side Effects of Oral Iron Prophylaxis in Pregnancy – Myth or Reality?

et al. 2006

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“…These side-effects are dose dependent and become overt at ferrous iron doses above 100-180 mg/day. However, placebo controlled studies in pregnant women have shown that ferrous iron doses of 105 mg/day has a side effect profile, which is not significantly different from placebo [47,48]. The slow release iron formulas Ferro Duretter, IberetFolic and ferrous sulphate with mucoproteose (Tardyferon) have fewer gastrointestinal side-effects (nausea, epigastric pain, constipation) than fast release formulas [45,49,50].…”

Section: Iron Formulas: Fast and Slow Release Formulasmentioning

confidence: 99%