The Prophylactic Effect of Dexamethasone on Postoperative Nausea and Vomiting in Women Undergoing Thyroidectomy

Wang, Jhi-Joung; Ho, Shung‐Tai; Liu, Yao–Chi; Liu, Yun-Hou; Liao, Yu Kuang

doi:10.1213/00000539-199907000-00036

Cited by 32 publications

(46 citation statements)

References 28 publications

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“…[3][4][5] Postoperative nausea and vomiting after thyroid surgery is especially common, with previous studies reporting a rate of 51% to 76%. [30][31][32] Similarly in our study, the most common adverse effect in the study groups were PONV, and we determined a decrease in adverse effects associated with opioid consumption in the combination group, demonstrating that a multimodal analgesic approach using adjunctive drugs reduces the need for opioid analgesic and decreases adverse effects. The incidence of PONV (65% vs 95%, respectively) and antiemetic requirements were less in the combination group and Group S than in the R and L Groups (P < 0.05).…”

Section: Discussionsupporting

confidence: 59%

Infiltration with ropivacaine plus lornoxicam reduces postoperative pain and opioid consumption

Karamanlıoğlu

Turan

Memiş

et al. 2005

Can J Anesth/J Can Anesth

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Purpose:To compare efficacy and patient outcome of wound infiltration with ropivacaine, lornoxicam, or their combination for control of pain following thyroid surgery. Methods:Eighty patients underwent thyroid surgery were randomly assigned to one of four groups. Before skin closure, local tissues were infiltrated with 12 mL saline in Group S, with 10 mL of ropivacaine 0.75% plus 2 mL saline in Group R, with 2 mL of lornoxicam (8 mg) plus 10 mL saline in Group L, and with 10 mL ropivacaine 0.75% plus 2 mL lornoxicam (8 mg) in Group RL. Pain scores, total and incremental meperidine consumption were recorded at 30 min, one, two, three, four, six, eight, 12, 18, and 24 hr postoperatively. Time to first analgesic requirement, patient satisfaction, and duration of hospital stay were also compared after surgery. Results:The pain scores in Group RL were significantly lower in the first 12 hr than in Group S, and in the first four hours than in Groups R and L (P < 0.01). The time to first analgesic requirement was significantly longer (14.8 ± 8.4 hr vs 5.9 ± 5.2 hr; P < 0.01), the total pethidine consumption was significantly less than Group S (34.0 ± 33.0 mg vs 78.0 ± 29.8 mg; P<0.001), return of gastrointestinal function, ambulation time, length of hospital stay (P < 0.05) were significantly shorter, and patient satisfaction (P < 0.01) was significantly better in Group RL than in Group S (P < 0.05). Conclusion: Wound infiltration with ropivacaine 0.75% plus lornoxicam 8 mg combination improved postoperative pain control and patient comfort, and decreased the need for opioids than the use of either drug alone. (14,8 ± 8,4 h vs 5,9 ± 5,2 h ; P < 0,01), la consommation totale de péthidine a été plus basse que dans le groupe S (34,0 ± 33,0 mg vs 78,0 ± 29,8 mg ; P < 0,001) Objectif

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Section: Discussionsupporting

confidence: 59%

Infiltration with ropivacaine plus lornoxicam reduces postoperative pain and opioid consumption

Karamanlıoğlu

Turan

Memiş

et al. 2005

Can J Anesth/J Can Anesth

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“…Some studies have demonstrated that preoperative intravenous administration of dexamethasone reduces the incidence of POST significantly. [22][23][24] We used a similar dose of dexamethasone as used in these studies, which may have conflicted with the proposed effect of the lubricants. In our study, however, both groups received the same dose of dexamethasone following intubation.…”

Section: Discussionmentioning

confidence: 99%

Application of triamcinolone acetonide paste to the endotracheal tube reduces postoperative sore throat: a randomized controlled trial

Park

Kim

Lee

et al. 2011

Can J Anesth/J Can Anesth

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“…4 Dexamethasone in a dose of 8-10 mg has been used frequently in the prevention of PONV. [5][6][7][8] In this study, in order to avoid possible adverse events after cortisone administration, we determined the minimal single dose of dexamethasone that, combined with ondansetron, provides effective prophylaxis of PONV after laparoscopic cholecystectomy.…”

mentioning

confidence: 99%

Dexamethasone 8 mg in combination with ondansetron 4 mg appears to be the optimal dose for the prevention of nausea and vomiting after laparoscopic cholecystectomy

Elhakim

Nafie

Mahmoud

et al. 2002

Can J Anesth/J Can Anesth

107

100

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The Prophylactic Effect of Dexamethasone on Postoperative Nausea and Vomiting in Women Undergoing Thyroidectomy

Cited by 32 publications

References 28 publications

Infiltration with ropivacaine plus lornoxicam reduces postoperative pain and opioid consumption

Infiltration with ropivacaine plus lornoxicam reduces postoperative pain and opioid consumption

Application of triamcinolone acetonide paste to the endotracheal tube reduces postoperative sore throat: a randomized controlled trial

Dexamethasone 8 mg in combination with ondansetron 4 mg appears to be the optimal dose for the prevention of nausea and vomiting after laparoscopic cholecystectomy

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