The Prophylactic and Therapeutic Effects of Glutamine- and Arginine-Enriched Diets on Radiation-Induced Enteritis in Rats

Ersin, Sinan; Tuncyurek, Pars; Esassolak, Mustafa; Alkanat, Murat; Büke, Çağrı; Yılmaz, Mustafa; Telefoncu, Azmi; Köse, Timur

doi:10.1006/jsre.1999.5808

Cited by 82 publications

(37 citation statements)

References 25 publications

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“…This clinical tableu may appear with severe symptoms such as diarrhea, tenesmus and rectal bleeding 17 . A previous study reported that [18][19][20][21][22] Gy radiation dose range can cause acute diarrhea 18 . In our study diarrhea was observed after 24 hours in all the rats affected by radiation.…”

Section: Discussionmentioning

confidence: 99%

The effect of amifostine on bacterial translocation after radiation ınduced acute enteritis

et al. 2016

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PURPOSE:To investigate the effects of amifostine on bacterial translocation and overgrowth in colonic flora after acute radiation enteritis in a rat model. METHODS:Thirty-two female Wistar albino rats were divided into four groups: Group-1 (n=8): only normal saline was administered intraperitoneally. Group-2 (n=8): first serum saline was administered intraperitoneally and 30 minutes later 20 Gy radiation was applied to abdominopelvic region. Group-3 (n=8): only amifostine 200 ml/kg was administered intraperitoneally and radiation was not applied.Group-4 (n=8): first amifostine 200 ml/kg was administered intraperitoneally and 30 minutes later 20 Gy radiation was applied to abdominopelvic region. On the 5th day after radiation, samples of mesenteric lymph tissues and cecal contents were taken by laparotomy for microbiological culture. RESULTS:Intraperitoneal amifostine administration significantly decreased the bacterial overgrowth related to radiation in colon but did not significantly decrease the bacterial translocation. CONCLUSİON:Although not providing a full protection on the damaged mucosal barrier, amifostine significantly decreased the bacterial overgrowth in the cecal content after high dose radiation. There is a need to find out appropriate amifostine dose under different radiation applications avoiding bacterial translocation in gastrointestinal system.

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Section: Discussionmentioning

confidence: 99%

The effect of amifostine on bacterial translocation after radiation ınduced acute enteritis

et al. 2016

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“…In experimental studies, a 7-d glutamineor arginine-enriched diet administered both pre-and post-irradiation showed that they have protective effects on gut mucosa in the post-irradiation state. However, pre-and post-irradiation administration together do not provide superior protection compared to post-irradiation administration alone [129] . Administration of insulin-like g rowth factor (IGF)-I immediately following abdominal irradiation increases small-intestinal mass and improves indicators of mucosal integrity, suggesting acceleration of smallintestinal mucosal recovery from radiation injury [130] .…”

Section: Prevention Of Radiation Colitismentioning

confidence: 92%

Recent advances in the management of radiation colitis

Kountouras¹,

Zavos²

2008

WJG

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“…Moreover, other researchers have shown that arginine intake (0.33 g daily) improves the intestinal barrier function [25].…”

Section: Effects Of Arginine On Intestinal Functionmentioning

confidence: 97%

Immunonutrition in perioperative phase: An insight into the integrated treatment of cardiac surgery patients

L¹,

Maio²,

Cavone³

et al. 2015

J Integr Cardiol

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The clinical condition of a patient scheduled for surgery, in addition to being a crucial point for the positive result of the operation, is certainly able to affect also the post-surgery phase.For this reason, the patient needs to be evaluated globally and in an interdisciplinary way in order to limit eventual early or late complications after surgery as much as possible. In the last few years, the knowledge gained through the progress and developments of basic research aimed at assessing the effects of some principles having immunostimulant properties, has allowed a clearer understanding of the role of the gut and of the gut-associated lymphoid tissue (GALT) in the immunologic dynamics of protection of the body against extraneous pathogens and agents that regulate the tolerance to commensal bacteria and food antigens.

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The Prophylactic and Therapeutic Effects of Glutamine- and Arginine-Enriched Diets on Radiation-Induced Enteritis in Rats

Cited by 82 publications

References 25 publications

The effect of amifostine on bacterial translocation after radiation ınduced acute enteritis

The effect of amifostine on bacterial translocation after radiation ınduced acute enteritis

Recent advances in the management of radiation colitis

Immunonutrition in perioperative phase: An insight into the integrated treatment of cardiac surgery patients

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