The PROPHET System and resource sharing

Raub, William F.

doi:10.1007/978-1-4757-0546-1_29

Cited by 36 publications

(11 citation statements)

References 3 publications

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“…20 To determine the significance of differing ratios of apoLp[a] and apo B concentrations in tissue versus plasma, the ratios of ratios were B Rgure 2. Immunohistochemical localization of (A) apo[a] and (B) apo B in sections from aortocoronary bypass vein grafts.…”

Section: Discussionmentioning

confidence: 99%

Quantitation and localization of apolipoproteins [a] and B in coronary artery bypass vein grafts resected at re-operation.

et al. 1989

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Section: Discussionmentioning

confidence: 99%

Quantitation and localization of apolipoproteins [a] and B in coronary artery bypass vein grafts resected at re-operation.

et al. 1989

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“…To test this hypothesis for the rabbit, the system of differential equations de- algorithm. The fitting was performed using the PROPHET computing system (23), and using the public procedure "DIF- were essentially identical to those obtained using Eq. 5 (see Table II).…”

Section: Discussionmentioning

confidence: 99%

In vivo behavior of radioiodinated rabbit antithrombin III. Demonstration of a noncirculating vascular compartment.

Carlson¹,

Atencio²,

Simon³

1984

J. Clin. Invest.

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Abstract. Rabbit antithrombin III (AT), purified by heparin-agarose, was labeled with iodine-131 by either the glucose oxidase-lactoperoxidase or iodine monochloride techniques. When intravenously injected, the disappearance of the '3'I-AT from plasma was characterized by rapid initial decreases, and three-exponential equations were required for best fit of the plasma disappearance curves. This rapid '3'I-AT removal was not caused by denaturation, as shown by comparison with results obtained when '3'I-AT was biologically screened (injected into a first rabbit, and then transferred 16 h later in whole plasma to a second for kinetic evaluation) before injection. Thus, the same rapid initial loss ofplasma '3'I-AT was observed with screened preparations, and the plasma fractional catabolic rates of 0.716±0.048 and 0.673±0.051 day-' for unscreened and screened '3'I-AT were not significantly different. These results support the hypothesis that a vascular-endothelial AT compartment is present in rabbit. The fractions of the total-body AT in the plasma, the vascular-endothelial and the extravascular compartments were 0.337±0.031, 0.178+0.056, and 0.485±0.069, respectively.Two three-compartment kinetic models are discussed. The first pictures AT as distributing independently between plasma and two other compartments, and the second sees AT as first passing to the vascular-endothelial compartment, and then directly into the extravascular

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“…The system supported research promoting the emergence of a predictive science regarding drugs and drugrelated phenomena. NIH offered biomedical scientists throughout the nation an opportunity to evaluate computer-based information-handling methods in searching for chemical-biological relationships [ 168 ]. Rubin [ 174 ], at Bolt, Beranek and Newman, described the PROPHET system as a specialized computer resource developed by NIH to aid scientists who studied the mechanisms of drug actions and other chemical/biological interrelationships.…”

Section: Examples Of Early Pharm Systemsmentioning

confidence: 99%

Pharmacy Information (PHARM) Systems

Collen¹,

Nelson

2015

Health Informatics

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Computer-based pharmacy (PHARM) systems have notably improved the quality and safety of medical care. By the 1980s automated ward-based medication cabinets were available to support drug administration and pharmacy management, overcoming problems encountered when drugs were stocked in nursing stations, administered to patients at different hospital locations, and recorded in different paper-based records. When the growing use of prescribed drugs in patient care resulted in an increasing number of adverse drug events (ADEs), PHARM systems were used together with computer-based physician order entry/results reporting systems (CPOE/RRs) systems to prevent and detect such events. With greater computer storage capabilities and much larger databases, PHARM systems were better able to discover and monitor ADEs in inpatient and outpatient care for prescription drugs and over-the-counter medications. With links to comprehensive patient data within a defi ned population database, they could calculate rates of diseases and rates of ADEs. Medication reconciliation and interoperability standards such as RxNorm and Health Level 7 messaging supported sharing information across institutions. User-centered design focused on making systems more effective and reducing alert fatigue. Pharmacogenomics is expected to infl uence medication therapy and improve the safety and effectiveness of prescribed drugs; the interactions which occur in polypharmacy will lead to fewer medication complications in the elderly; and better understanding of pharmacokinetics will lead to improved dosing and timing of medications.

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The PROPHET System and resource sharing

Cited by 36 publications

References 3 publications

Quantitation and localization of apolipoproteins [a] and B in coronary artery bypass vein grafts resected at re-operation.

Quantitation and localization of apolipoproteins [a] and B in coronary artery bypass vein grafts resected at re-operation.

In vivo behavior of radioiodinated rabbit antithrombin III. Demonstration of a noncirculating vascular compartment.

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