The Properties and Distribution of Pas Positive Substances in the Nervous System of the Senile Dog

The occurrence of lipofuscin pigment as related to aging in the lumbar spinal cord, dorsal root ganglia and paravertebral ganglia of the dog and pig

“…Strehler (1964) This Is in agreement with Strehler's (1964) observations. Wolf and Pappenheimer (194$), Sulkin (1955a), and Nandy (1966) also reported using a similar Zlehl-Neelson stain to demon strate the acid fast properties of lipofuscln.…”

“…by Sulkln (1953, 1955a, 1955%), Whlteford (1964), and Whlteford and Getty (1966. Sulkln (l955a), on the basis of a variety of histochemlcal procedures, concluded that lipofuscin was widely distributed in the nervous system, but was not found in dogs under 10 years of age.…”

Extrinsic and intrinsic blood supply and histomorphological changes associated with age in the cerebral arteries and brain nuclei in dog (Canis familiaris) and pig (Sus scrofa domestica)

“…Wahren (1957) described the occurrence of lipofuscin pigment in pallidum and nucleus tuberolateralis at different age intervals. Sulkin and Kuntz (1952) and Sulkin (1955) observed the varying degree and frequency of pigment distribution in dif ferent nuclei of the nervous system in man and dog. Strehler, et al (1959) studied the quantitative increase of the lipofuscin pigment in the cardiac muscle and found an increasing trend with age.…”

“…Similar studies to indicate loss of purkinje cells with age have been carried out by Harms (1924) and Inukai (1928). Sulkin (1955) …”

Age changes in the canine pancreas: histomorphological, electron microscopic, and biochemical study

“…The occurrence of lipofuscin has been reported in a variety of organs, such as the canine and porcine brain (Whiteford and Getty, 1966) and rodent brain (Reichel ejb ^ 1968), the adrenal, ovary, testes, heart, and kidney of the rat (Reichel,196 8), the canine heart (Munnell and Getty,196 8c), the spinal cord and ventral horn (Sulkin, 1955;Few and Getty, 1967), spinal ganglia (Bondareff, 1957), and the liver (Haraszti et , 1967).…”