The propagation speeds of calcium action potentials are remarkably invariant

Jaffe, Lionel F.

doi:10.1016/s0248-4900(03)00090-x

Cited by 10 publications

(7 citation statements)

References 130 publications

(41 reference statements)

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“…Consequently the IP 3 levels remained constant and then no Ca 2+ release occurred through this path, indicating that intracellular Ca 2+ stores were not involved in the mechanism of the ultrafast Ca 2+ wave. Furthermore, according to previous Ca 2+ waves description and classification, most of the Ca 2+ waves with a speed >10 mm.s −1 were not governed by intracellular Ca 2+ processes 5 6 .…”

Section: Discussionmentioning

confidence: 63%

“…One way of cellular communication is by intercellular Ca 2+ waves, the propagation of an increase in intracellular Ca 2+ concentration. Such intercellular Ca 2+ waves have been induced in vitro by mechanical, electrical or chemical stimuli 2 3 4 and classified according to the mechanism involved and the velocity amplitude, denominating the ultrafast Ca 2+ wave as an electrically propagated wave 5 6 . Novel insights have been gained from mathematical models which connect clusters of SMCs 7 8 9 10 11 .…”

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confidence: 99%

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Intercellular ultrafast Ca2+ wave in vascular smooth muscle cells: numerical and experimental study

Quíjano

Raynaud

Nguyen

et al. 2016

Sci Rep

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Vascular smooth muscle cells exhibit intercellular Ca2+ waves in response to local mechanical or KCl stimulation. Recently, a new type of intercellular Ca2+ wave was observed in vitro in a linear arrangement of smooth muscle cells. The intercellular wave was denominated ultrafast Ca2+ wave and it was suggested to be the result of the interplay between membrane potential and Ca2+ dynamics which depended on influx of extracellular Ca2+, cell membrane depolarization and its intercel- lular propagation. In the present study we measured experimentally the conduction velocity of the membrane depolarization and performed simulations of the ultrafast Ca2+ wave along coupled smooth muscle cells. Numerical results reproduced a wide spectrum of experimental observations, including Ca2+ wave velocity, electrotonic membrane depolarization along the network, effects of inhibitors and independence of the Ca2+ wave speed on the intracellular stores. The numerical data also provided new physiological insights suggesting ranges of crucial model parameters that may be altered experimentally and that could significantly affect wave kinetics allowing the modulation of the wave characteristics experimentally. Numerical and experimental results supported the hypothesis that the propagation of membrane depolarization acts as an intercellular messenger mediating intercellular ultrafast Ca2+ waves in smooth muscle cells.

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Section: Discussionmentioning

confidence: 63%

mentioning

confidence: 99%

Intercellular ultrafast Ca2+ wave in vascular smooth muscle cells: numerical and experimental study

Quíjano

Raynaud

Nguyen

et al. 2016

Sci Rep

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“…D Ca is the effective diffusion coefficient of spreading from one cell to the neighboring cells along the vessel wall. Note that the speed of the signal in the confined space of the vessel wall is faster than 3D diffusivity, and is related to the speed of an action potential 50 . can also be approximated through Eq.…”

Section: Methodsmentioning

confidence: 99%

The effects of valve leaflet mechanics on lymphatic pumping assessed using numerical simulations

Mei

Maimon

et al. 2019

Sci Rep

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The lymphatic system contains intraluminal leaflet valves that function to bias lymph flow back towards the heart. These valves are present in the collecting lymphatic vessels, which generally have lymphatic muscle cells and can spontaneously pump fluid. Recent studies have shown that the valves are open at rest, can allow some backflow, and are a source of nitric oxide (NO). To investigate how these valves function as a mechanical valve and source of vasoactive species to optimize throughput, we developed a mathematical model that explicitly includes Ca 2+ -modulated contractions, NO production and valve structures. The 2D lattice Boltzmann model includes an initial lymphatic vessel and a collecting lymphangion embedded in a porous tissue. The lymphangion segment has mechanically-active vessel walls and is flanked by deformable valves. Vessel wall motion is passively affected by fluid pressure, while active contractions are driven by intracellular Ca 2+ fluxes. The model reproduces NO and Ca 2+ dynamics, valve motion and fluid drainage from tissue. We find that valve structural properties have dramatic effects on performance, and that valves with a stiffer base and flexible tips produce more stable cycling. In agreement with experimental observations, the valves are a major source of NO. Once initiated, the contractions are spontaneous and self-sustained, and the system exhibits interesting non-linear dynamics. For example, increased fluid pressure in the tissue or decreased lymph pressure at the outlet of the system produces high shear stress and high levels of NO, which inhibits contractions. On the other hand, a high outlet pressure opposes the flow, increasing the luminal pressure and the radius of the vessel, which results in strong contractions in response to mechanical stretch of the wall. We also find that the location of contraction initiation is affected by the extent of backflow through the valves.

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“…First, the flagellate Koruga [from termite ( Mastotermes darwiniensis ) gut] exhibits synchronous 200 μm/s front‐to‐back synchronous waves of both indentation and of metachronous ciliary bending. By indentation waves, I mean ones that look like the much slower ones which move along many eggs (Jaffe and Créton, 1998) and are illustrated in Jaffe (1999). More detailed study of these waves in Koruga showed that the indentation waves induce the metachronal ones (Cleveland and Cleveland, 1966).…”

Section: Evidence That the Listed Waves Are Calcium Waves Which Are Smentioning

confidence: 99%

“… Proposed new calcium‐wave speed spectrum, including waves propagated by CICI f, fertilization; fl, flagellar; nfl, non‐flagellar. Modified from Figure 1 of Jaffe (2003) (© Portland Press) and Figure 1 of Jaffe (1999) (© John Wiley & Sons, Inc.) with permission, which lacks a CICI category. …”

Section: Introductionmentioning

confidence: 99%

Stretch‐activated calcium channels relay fast calcium waves propagated by calcium‐induced calcium influx

Jaffe

2007

Biology of the Cell

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For nearly 30 years, fast calcium waves have been attributed to a regenerative process propagated by CICR (calcium-induced calcium release) from the endoplasmic reticulum. Here, I propose a model containing a new subclass of fast calcium waves which is propagated by CICI (calcium-induced calcium influx) through the plasma membrane. They are called fast CICI waves. These move at the order of 100 to 1000 µm/s (at 20 • C), rather than the order of 3 to 30 µm/s found for CICR. Moreover, in this proposed subclass, the calcium influx which drives calcium waves is relayed by stretch-activated calcium channels. This model is based upon reports from approx. 60 various systems. In seven of these reports, calcium waves were imaged, and, in five of these, evidence was presented that these waves were regenerated by CICI. Much of this model involves waves that move along functioning flagella and cilia. In these systems, waves of local calcium influx are thought to cause waves of local contraction by inducing the sliding of dynein or of kinesin past tubulin microtubules. Other cells which are reported to exhibit waves, which move at speeds in the fast CICI range, include ones from a dozen protozoa, three polychaete worms, three molluscs, a bryozoan, two sea urchins, one arthropod, four insects, Amphioxus, frogs, two fish and a vascular plant (Equisetum), together with numerous healthy, as well as cancerous, mammalian cells, including ones from human. In two of these systems, very gentle local mechanical stimulation is reported to initiate waves. In these non-flagellar systems, the calcium influxes are thought to speed the sliding of actinomyosin filaments past each other. Finally, I propose that this mechanochemical model could be tested by seeing if gentle mechanical stimulation induces waves in more of these systems and, more importantly, by imaging the predicted calcium waves in more of them.

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The propagation speeds of calcium action potentials are remarkably invariant

Cited by 10 publications

References 130 publications

Intercellular ultrafast Ca2+ wave in vascular smooth muscle cells: numerical and experimental study

Intercellular ultrafast Ca2+ wave in vascular smooth muscle cells: numerical and experimental study

The effects of valve leaflet mechanics on lymphatic pumping assessed using numerical simulations

Stretch‐activated calcium channels relay fast calcium waves propagated by calcium‐induced calcium influx

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