The promotional effect of IL-22 on mineralization activity of periodontal ligament cells

Kato-Kogoe, Nahoko; Nishioka, Toshihiro; Kawabe, Mayumi; Kataoka, Fusa; Yamanegi, Koji; Yamada, Naoko; Hara, Masaki; Yamamoto, Tadashi; Nakasho, Keiji; Urade, Masahiro; Terada, Nobuyuki; Ohyama, Hideki

doi:10.1016/j.cyto.2012.03.024

Cited by 28 publications

(22 citation statements)

References 39 publications

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“…The bone anabolic effects of IL-22 are not unique to this cytokine, and other proinflammatory cytokines also have been shown to have pro-osteogenic effects. These include, IL-1, IL-17, IL-18, IL-33 and oncostatin M, which under certain conditions can enhance osteoblast differentiation [38–41]. Although the specific mediators have not been rigorously defined, T cells and monocyte–macrophage lineage cells have also been shown to exert pro-osteogenic effects on osteoblast precursors, providing additional evidence that under certain conditions immune cells and their products may contribute not only to catabolic processes but also participate in anabolic tissue responses, at least with respect to bone [42–45].…”

Section: Mechanisms Of Pathological Bone Remodeling In the Spasmentioning

confidence: 99%

Osteoimmunology and Bone Homeostasis: Relevance to Spondyloarthritis

Goldring

2013

Curr Rheumatol Rep

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The seronegative spondyloarthopathies (SpA) share certain common articular and peri-articular features that differ from rheumatoid arthritis (RA) and other forms of inflammatory arthritis. These include the tendency of the SpAs to involve the axial skeleton in addition to the diarthrodial joints, and the prominent involvement of the extra-articular entheses (sites of ligamentous and tendon insertion), which are not common sites of primary pathology in RA and other inflammatory arthropathies. The differential anatomic sites of bone pathology in the SpAs in comparison to the other forms of arthritis suggest that the underlying pathogenic processes and cellular and molecular mechanisms that account for the peri-articular bone pathology involve different underlying disease mechanisms. This review will highlight the molecular and cellular processes that are involved in the pathogenesis of the skeletal pathology in the SpAs, and provide evidence that many of the factors involved in regulation of bone cell function exhibit potent immune-regulatory activity, providing support for the general concept of osteoimmunology.

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Section: Mechanisms Of Pathological Bone Remodeling In the Spasmentioning

confidence: 99%

Osteoimmunology and Bone Homeostasis: Relevance to Spondyloarthritis

Goldring

2013

Curr Rheumatol Rep

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“…Kato‐Kogoe et al . () demonstrated the presence of this cytokine and its receptor in the PDL of patients with moderate or severe chronic periodontitis in contrast to their reduced or absent expression in healthy gingival tissues. The authors suggest that IL‐22 enhanced the mineralized matrix‐forming activities of PDL cells.…”

Section: Discussionmentioning

confidence: 98%

Absence of interleukin 22 affects the oral microbiota and the progression of induced periapical lesions in murine teeth

et al. 2014

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This study revealed differences in the composition of oral microbiota between mice that may be taken into account in the susceptibility to infections and development of periapical lesions. The absence of IL-22 in mice resulted in smaller periapical lesions with fewer osteoclasts at the final experimental period, suggesting the participation of IL-22 in the host immune and inflammatory response to a periradicular infection.

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“…Of course, katoKogoe et al found that gingival tissues showed modest or no gene expressions of IL-22 [9]. It may be indicative of another source of this cytokine in periodontium that is not included in our samples such as PDL and or alveolar bone.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, Aranha et al (2013) considered a protective role for T H 9 and T H 22 cytokines [24]; and Katogoe et al (2012) suggested that IL-22 has the potential to promote mineralizing activity in PDL cells and to develop appropriate regenerative therapy [9].…”

Section: Discussionmentioning

confidence: 99%

“…Of course, it was shown that IL-1β in cooperation with IL-22 could increase T H 17 cell accumulation in periodontally diseased tissues to enhance CCL20 production [8] and gingival tissues showed modest or no gene expressions of IL-22 [9]. However there are numerous studies that show a direct relationship between the amount of this cytokine and some diseases such as Crohn's disease, rheumatoid arthritis, psoriasis, atopic dermatitis, sepsis, systemic lupus erythematosous Abstract IL-22 is a cytokine that is assumed to improve anti-microbial defense of epidermal and epithelial cells and the cells of gastrointestinal and respiratory systems.…”

Section: Introductionmentioning

confidence: 99%

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