The promotion of liver regeneration in mice after a partial hepatectomy as a result of the modulation of macrophage activation by dexmedetomidine

Yue, Li-hui; Wang, Lina; Zhu, Xichun; Peng, Yanhui

doi:10.1016/j.trim.2022.101577

Cited by 8 publications

(6 citation statements)

References 27 publications

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“…By comprehensive comparison, among the three different doses, middle-dose Dex had the advantages of good sedation effect and weak agitation degree at high dose and short awakening time at low dose. In the wake period of anesthesia, the ideal sedation effect can prevent the occurrence of agitation in the wake period and thus avoid the fluctuation of vital signs in the wake period [17][18][19]. In this study, HR, CI, and RPP of the medium-dose and high-dose groups were lower than those of the low-dose group, and RSS scores of the medium-dose and high-dose groups were significantly higher than those of the low-dose group, which further confirmed the exact sedative effect of high-dose Dex, and the effect of stabilizing vital signs was consistent with that of high-dose Dex.…”

Section: Related Workmentioning

confidence: 99%

Effects of Different Doses of Dex Anesthesia on Inflammatory Factors and Hemodynamics in Patients Undergoing Neurosurgery and Its Relationship with RSS Score

et al. 2022

BioMed Research International

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The effects of different doses of dexmedetomidine (Dex) anesthesia on inflammatory factors and hemodynamics in patients undergoing neurosurgery and its relationship with RSS scores are analyzed. A total of 102 patients who received neurosurgery in our hospital from March 2021 to March 2022 are selected. According to different intraoperative Dex dose, the enrolled patients are randomly divided into low-, medium-, and high-dose groups, 34 patients in each group. In this study, hemodynamic indexes, inflammatory factors, anesthesia effect, and the Ramsay sedation scale (RSS) score are compared in each groups. The experimental results show that in neurosurgery, compared with low-dose Dex, high-dose Dex can better maintain patients’ intraoperative hemodynamic parameters and effectively inhibit postoperative inflammatory response, but postoperative awakening time is also relatively prolonged, while medium-dose Dex can effectively control patients’ awakening time.

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Section: Related Workmentioning

confidence: 99%

Effects of Different Doses of Dex Anesthesia on Inflammatory Factors and Hemodynamics in Patients Undergoing Neurosurgery and Its Relationship with RSS Score

et al. 2022

BioMed Research International

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“… 33 Regarding the potential implication of α 2B AR, a recent study demonstrated that in the case of PHx, the regenerative effect of an α 2 AR agonist is due to macrophage differentiation toward an anti-inflammatory profile and not from direct action on hepatocytes. 46 Since we did not find any indication of alteration in the pro/anti-inflammatory cytokines ratio due to the adrenergic signaling, we supposed that this was not the principal mechanism maintaining liver physiology after iNKT cell activation. Consequently, we opted to pre-treat mice with Phe, a selective α 1 AR agonist, before αGC administration.…”

Section: Discussionmentioning

confidence: 75%

Targeting adrenergic receptors to mitigate invariant natural killer T cells-induced acute liver injury

Gonzatti,

Freire,

Antunes

et al. 2023

iScience

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“…Dexmedetomidine also promotes the M2 activity of macrophages via the PPARγ/STAT3 pathway and inhibits the pro-inflammatory innate immune activation in the liver ( Zhou et al, 2020 ). Dexmedetomidine also modulates the activation of Kupffer cells by activating alpha 2-adrenergic receptors (α2B-ARs), which transforms them into anti-inflammatory phenotypes and promotes liver regeneration ( Yue et al, 2022 ).…”

Section: Macrophages and Anestheticmentioning

confidence: 99%

Effects of propofol on macrophage activation and function in diseases

Tao

Wang

et al. 2022

Front. Pharmacol.

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Macrophages work with monocytes and dendritic cells to form a monocyte immune system, which constitutes a powerful cornerstone of the immune system with their powerful antigen presentation and phagocytosis. Macrophages play an essential role in infection, inflammation, tumors and other pathological conditions, but these cells also have non-immune functions, such as regulating lipid metabolism and maintaining homeostasis. Propofol is a commonly used intravenous anesthetic in the clinic. Propofol has sedative, hypnotic, anti-inflammatory and anti-oxidation effects, and it participates in the body’s immunity. The regulation of propofol on immune cells, especially macrophages, has a profound effect on the occurrence and development of human diseases. We summarized the effects of propofol on macrophage migration, recruitment, differentiation, polarization, and pyroptosis, and the regulation of these propofol-regulated macrophage functions in inflammation, infection, tumor, and organ reperfusion injury. The influence of propofol on pathology and prognosis via macrophage regulation is also discussed. A better understanding of the effects of propofol on macrophage activation and function in human diseases will provide a new strategy for the application of clinical narcotic drugs and the treatment of diseases.

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The promotion of liver regeneration in mice after a partial hepatectomy as a result of the modulation of macrophage activation by dexmedetomidine

Cited by 8 publications

References 27 publications

Effects of Different Doses of Dex Anesthesia on Inflammatory Factors and Hemodynamics in Patients Undergoing Neurosurgery and Its Relationship with RSS Score

Effects of Different Doses of Dex Anesthesia on Inflammatory Factors and Hemodynamics in Patients Undergoing Neurosurgery and Its Relationship with RSS Score

Targeting adrenergic receptors to mitigate invariant natural killer T cells-induced acute liver injury

Effects of propofol on macrophage activation and function in diseases

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