The Promise of viral phage therapy in hernia mesh infection, is this the biological ‘silver bullet’ of the future?

Speck, Peter; Warner, Morgyn S.; Clark, Jason; Jacombs, Anita; Karatassas, Alex; Hensman, Chris

doi:10.1111/ans.16214

Cited by 1 publication

(4 citation statements)

References 49 publications

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“…44 The incidence is affected by various factors, such as mesh location and size, mesh material type and structure, and different bacterial species, concentrations, and adherence properties, and may significantly increase in high-risk situations like surgical site infection, for instance. 45,46 Infection as one kind of hernia complication is usually caused by colonization of microorganisms like bacteria, fungi, etc. ; colonization is when microorganisms fall from the environment to a body surface, settling and growing in certain areas without causing disease in the person.…”

Section: The Roots Of Mesh-related Complicationsmentioning

confidence: 99%

“…Therefore, it is technically viable to combine phages with meshes. 45 To sum up, in consideration of antibiotic resistance, utilizing antibiotics has gradually withdrawn from the stage of history, while metal nanoparticles and antimicrobial peptides, offering broad-spectrum sterilization, are the main directions of antimicrobial research recently, and many new strategies have emerged. What are the safe and effective concentrations of metal particles in vivo, the structural design of AMPs, and the long-acting and slow release of antibacterial substances are all worthy of further investigation.…”

Section: Strategies For Reducing Postoperative Complicationsmentioning

confidence: 99%

“…The reported incidence of infection related to meshes following hernioplasty is between 1% and 8% according to different research . The incidence is affected by various factors, such as mesh location and size, mesh material type and structure, and different bacterial species, concentrations, and adherence properties, and may significantly increase in high-risk situations like surgical site infection, for instance. , …”

Section: The Roots Of Mesh-related Complicationsmentioning

confidence: 99%

“…Although phages have not been directly used in mesh at present, phages can be immobilized by various solid substrates by various methods currently. Therefore, it is technically viable to combine phages with meshes …”

Section: Strategies For Reducing Postoperative Complicationsmentioning

confidence: 99%

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Latest Trends on the Attenuation of Systemic Foreign Body Response and Infectious Complications of Synthetic Hernia Meshes

Fang

Wang

et al. 2021

ACS Appl. Bio Mater.

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Throughout the past few years, hernia incidence has remained at a high level worldwide, with more than 20 million people requiring hernia surgery each year. Synthetic hernia meshes play an important role, providing a microenvironment that attracts and harbors host cells and acting as a permanent roadmap for intact abdominal wall reconstruction. Nevertheless, it is still inevitable to cause not-so-trivial complications, especially chronic pain and adhesion. In long-term studies, it was found that the complications are mainly caused by excessive fibrosis from the foreign body reaction (FBR) and infection resulting from bacterial colonization. For a thorough understanding of their complex mechanism and providing a richer background for mesh development, herein, we discuss different clinical mesh products and explore the interactions between their structure and complications. We further explored progress in reducing mesh complications to provide varied strategies that are informative and instructive for mesh modification in different research directions. We hope that this work will spur hernia mesh designers to step up their efforts to develop more practical and accessible meshes by improving the physical structure and chemical properties of meshes to combat the increasing risk of adhesions, infections, and inflammatory reactions. We conclude that further work is needed to solve this pressing problem, especially in the analysis and functionalization of mesh materials, provided of course that the initial performance of the mesh is guaranteed.

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Section: The Roots Of Mesh-related Complicationsmentioning

confidence: 99%

Section: Strategies For Reducing Postoperative Complicationsmentioning

confidence: 99%