The promise of omega-3 against sudden unexpected death in epilepsy: until further notice, it remains innocent, until proven guilty

Lopes, Antônio Carlos; Cysneiros, Roberta Monterazzo; Arida, Ricardo Mário; Silva, Maurício Rocha e

doi:10.1590/s0004-282x2012005000014

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…16,23,24 Human DHA status is the result of both diet and endogenous synthesis, and deficiency is associated with the risk of a variety of cardiac and mental health conditions. Unbalanced omega-6/omega-3 status and low DHA are associated with cognitive impairment in a study of children with intellectual disabilities, 25 worse outcomes in traumatic brain injury, 26 increased cardiovascular disease risk, 27 sudden death due to cardiovascular disease risk, 27 sudden unexpected death in epilepsy, 28 primary open-angle glaucoma, 29 and age-related macular degeneration. 30 There is evidence linking imbalances of these fatty acids in pregnant women with the risk of cerebral palsy.…”

Section: Common Biochemical and Nutrient Deficiencies And Their Potenmentioning

confidence: 99%

Potential Benefits of Ameliorating Metabolic and Nutritional Abnormalities in People With Profound Developmental Disabilities

Glick

Fischer

2017

Nutr Metab Insights

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BACkgRouND: People with profound developmental disabilities have some of the most severe neurological impairments seen in society, have accelerated mortality due to huge medical challenges, and yet are often excluded from scientific studies. They actually have at least 2 layers of conditions: (1) the original disability and (2) multiple under-recognized and underexplored metabolic and nutritional imbalances involving minerals (calcium, zinc, and selenium), amino acids (taurine, tryptophan), fatty acids (linoleic acid, docosahexaenoic acid, arachidonic acid, adrenic acid, Mead acid, plasmalogens), carnitine, hormones (insulinlike growth factor 1), measures of oxidative stress, and likely other substances and systems. SuMMARy: This review provides the first list of metabolic and nutritional abnormalities commonly found in people with profound developmental disabilities and, based on the quality of life effects of similar abnormalities in neurotypical people, indicates the potential effects of these abnormalities in this population which often cannot communicate symptoms. key MeSSAgeS: We propose that improved understanding and management of these disturbed mechanisms would enhance the quality of life of people with profound developmental disabilities. Such insights may also apply to people with other conditions associated with disability, including some diseases requiring stem cell implantation and living in microgravity.

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