The proliferative ventricular zone in adult vertebrates: a comparative study using reptiles, birds, and mammals

García‐Verdugo, José Manuel; Ferrón, Sacri R.; Flames, Nuria; Collado, L.; Desfilis, Ester; Font, Enrique

doi:10.1016/s0361-9230(01)00769-9

Cited by 180 publications

(163 citation statements)

References 73 publications

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“…In contrast to mammals, radial glia persist in the adult CNS of nonmammalian vertebrates (García-Verdugo et al, 2002;Kálmán, 2002;Zupanc and Clint, 2003). A prevailing view is the link between persisting radial glia and pronounced neural stem cell activity in nonmammalian vertebrates (Alvarez-Buylla et al, 2001;Götz et al, 2002).…”

Section: Typical Glia Do Not Serve As Stem Cells In the Adult Zebrafimentioning

confidence: 99%

Stem Cells in the Adult Zebrafish Cerebellum: Initiation and Maintenance of a Novel Stem Cell Niche

Kaslin¹,

Ganz²,

Geffarth³

et al. 2009

J. Neurosci.

186

278

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In the adult CNS, neurogenesis takes place in special niches. It is not understood how these niches are formed during development and how they are maintained. In contrast to mammals, stem cell niches are abundant in zebrafish and also found in other parts of the brain than telencephalon. To understand common characteristics of neural stem cell niches in vertebrates, we studied the origin and architecture of a previously unknown stem cell niche using transgenic lines, in vivo imaging, and marker analysis. We show that bipotent stem cells are maintained in a distinct niche in the adult zebrafish cerebellum. Remarkably, the stem cells are not typical glia but instead retain neuroepithelial characteristics. The cerebellar stem cell niche is generated by the coordinated displacement of ventricle and rhombic lip progenitors in a two-step process involving morphogenetic movements and tissue growth. Importantly, the niche and its stem cells still remain in ventricular contact through a previously unknown derivative of the ventricle. Factors propagated in the ventricle are thought to be important regulators of stem cell activity. To test the requirements of one family of important factors, Fibroblast growth factors, we used zebrafish with an inducible dominant-negative Fgf receptor. Inhibition of Fgf signaling leads to significant reduction of stem cell activity. In contrast to the predominant view, adult neural stem cells in nonmammalian vertebrates show more neuroepithelial than glial characteristics. Nevertheless, retained epithelial properties such as distinct polarization and ventricular contact are critical common determinants to maintain neural stem cell activity in vertebrates.

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Section: Typical Glia Do Not Serve As Stem Cells In the Adult Zebrafimentioning

confidence: 99%

Stem Cells in the Adult Zebrafish Cerebellum: Initiation and Maintenance of a Novel Stem Cell Niche

Kaslin¹,

Ganz²,

Geffarth³

et al. 2009

J. Neurosci.

186

278

View full text Add to dashboard Cite

show abstract

“…These include: glial cells functioning as both precursor and support cells (Garcia-Verdugo et al 2002;Song et al 2002;Doetsch 2003 a,b;Merkle et al 2004;Seri et al 2004;Ma et al 2005), directed migration (Lois et al 1996;Bolteus and Bordey 2004), close association with the brain vasculature (Palmer et al 2000;Palmer 2002;Shen et al 2004), and specialised basal laminae (Mercier et al 2002;Campos 2005). The cellular machinery maintaining adult neurogenesis appears, therefore, to be shared by widely disparate taxa.…”

Section: Comparison Between the Neurogenic Niche Of P Clarkii And Thmentioning

confidence: 99%

Adult neurogenesis and cell cycle regulation in the crustacean olfactory pathway: from glial precursors to differentiated neurons

et al. 2007

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Adult neurogenesis is a characteristic feature of the olfactory pathways of decapod crustaceans. In crayfish and clawed lobsters, adult-born neurons are the progeny of precursor cells with glial characteristics located in a neurogenic niche on the ventral surface of the brain. The daughters of these precursor cells migrate during S and G 2 stages of the cell cycle along glial fibers to lateral (cluster 10) and medial (cluster 9) proliferation zones. Here, they divide (M phase) producing offspring that differentiate into olfactory interneurons. The complete lineage of cells producing neurons in these animals, therefore, is arranged along the migratory stream according to cell cycle stage. We have exploited this model to examine the influence of environmental and endogenous factors on adult neurogenesis. We find that increased levels of serotonin upregulate neuronal production, as does maintaining animals in an enriched (versus deprived) environment or augmenting their diet with omega-3 fatty acids; increased levels of nitric oxide, on the other hand, decrease the rate of neurogenesis. The features of the neurogenic niche and migratory streams, and the fact that these continue to function in vitro, provide opportunities unavailable in other organisms to explore the sequence of cellular and molecular events leading to the production of new neurons in adult brains.

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“…On the contrary, Radial glial structures are permanent feature in lower vertebrates (Lazzari et al 1997). In addition to providing crucial fibrous scaffolding that guides newly born neurons from the ventricular zone to their final destination, radial glial cells have been proven to play the pivotal role of omnipresent precursors that produce neurons and glia both in adult brain as well as during developmental stage (Campbell & Gotz 2002;Garcia-Verdugo et al 2002;Weissman et al 2003). Our result demonstrated that radial glial cells were present in virtually all brain regions where neurons are generated, thus underlining their key role in neuronal production in reptiles.…”

Section: The Potential Functions Of Radial Glial Structuresmentioning

confidence: 56%

Characterization of adult neurogenesis in lizardPhrynocephalus vlangalii(Agamidae: Reptilia)

Shao

Fan

et al. 2012

Italian Journal of Zoology

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Adult neurogenesis, a process of giving rise to neurons and glia from progenitors residing in restricted regions of the adult central nervous system (CNS) throughout life, varies considerably across species. The role of adult neurogenesis in reptiles, the amniotic vertebrates that possess spontaneous regenerative capacity is less known. In the present study, we used Phrynocephalus vlangalii -a typical reptile in northwest of China to investigate the cell proliferation and general pattern of glial fibrillary acidic protein (GFAP)-immunoreactivity in the brain of lizard. Compared with mammals, the brains of P. vlangaliiowned have simpler cytoarchitectonical patterns but a more widespread neurogenesis. Bromodeoxyuridine (BrdU)-labeled cells were mostly distributed in the ventricular zone of lateral ventricle with cell proliferation highest in the region referred to as anterior olfactory nucleus (AON). In addition, GFAP-immunostaining demonstrated differences in element, abundance and distribution. GFAP-positive cells were fundamentally represented by radial glial structures in telencephalon, diencephalon and mesencephalon. Furthermore, an intriguing finding was the emergence of GFAP-positive, star-shaped cells in the mesencephalon. We conclude that the cell proliferation and corresponding functions of glial lineage cells in lizards are closely implicated with phylogenetic development. Hence, reptiles provide excellent access for extracting core mechanisms of adult neurogenesis, which lays a good foundation to study the effect of different stimuli and exposure on the adult neurogenesis of reptiles.

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The proliferative ventricular zone in adult vertebrates: a comparative study using reptiles, birds, and mammals

Cited by 180 publications

References 73 publications

Stem Cells in the Adult Zebrafish Cerebellum: Initiation and Maintenance of a Novel Stem Cell Niche

Stem Cells in the Adult Zebrafish Cerebellum: Initiation and Maintenance of a Novel Stem Cell Niche

Adult neurogenesis and cell cycle regulation in the crustacean olfactory pathway: from glial precursors to differentiated neurons

Characterization of adult neurogenesis in lizardPhrynocephalus vlangalii(Agamidae: Reptilia)

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