The proliferative activity of neurilemomas

Lee, Kyu‐Sung; Nagashima, Tadashi; Cho, Kyung G.; Mampalam, Thomas J.; Pitts, Lawrence H.; Hoshino, Takao

doi:10.1016/0090-3019(89)90005-0

Cited by 23 publications

(12 citation statements)

References 17 publications

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“…The BrdU labelling index ranged from 0.1% to 3.1% (mean 0.9%) [7]. There was no difference between the BrdU labelling indices of Antoni type A and type B tissue [7]. Most intracanalicular tumours are primarily composed of Antoni type A tissue [7].…”

Section: Discussionmentioning

confidence: 88%

“…In addition, the BrdU labelling index reflects the growth potential of individual tumours, and is a useful guide in the follow-up of patients with incompletely resected tumour [7]. The BrdU labelling index ranged from 0.1% to 3.1% (mean 0.9%) [7]. There was no difference between the BrdU labelling indices of Antoni type A and type B tissue [7].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the amount and vascularity of residual AN are critical factors of regrowth. In addition, the BrdU labelling index reflects the growth potential of individual tumours, and is a useful guide in the follow-up of patients with incompletely resected tumour [7]. The BrdU labelling index ranged from 0.1% to 3.1% (mean 0.9%) [7].…”

Section: Discussionmentioning

confidence: 99%

“…There is no report on the natural history of the residual intracanalicular tumour. Little is known about the long-term natural history of an intracanalicular tumour [2,4,7].…”

Section: Introductionmentioning

confidence: 99%

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Long-term follow-up of the residual intracanalicular tumours after subtotal removal of acoustic neurinomas

et al. 1996

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We examined growth potential of residual intracanalicular tumours left from subtotal removal of large acoustic neurinomas. Eleven patients were followed-up by magnetic resonance (MR) imaging. The interval between surgery and MR study ranged from 12 to 29 years (median, 16 years). MR images of two patients showed no evidence of tumour remnant, and in six a small tumour was localized in the internal auditory canal. The other three showed an intracanalicular tumour protruding slightly towards the intracranial portion. This result suggests that the intracanalicular residual tumours have less risk of regrowth after subtotal removal of acoustic neurinomas. It is advisable to choose intracapsular, subtotal removal without opening the internal auditory canal in the treatment of acoustic neurinoma, if it is large in size and there is a high risk of nerve injury.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…There is no report on the natural history of the residual intracanalicular tumour. Little is known about the long-term natural history of an intracanalicular tumour [2,4,7].…”

Section: Introductionmentioning

confidence: 99%

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Long-term follow-up of the residual intracanalicular tumours after subtotal removal of acoustic neurinomas

et al. 1996

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“…Some investigators have explained the presence of cysts by the difference in the distribution of Antoni cells and the degeneration of tumor tissues. 11,16,22 However, recent studies have not found any relationship between the distribution of cysts and the 2 types of tissues. 20,23 An impairment of the blood-tumor barrier leading to an extravasation of serum proteins has also been proposed as a reason for the increase in cyst size.…”

Section: Pathophysiology Of Cyst Formationmentioning

confidence: 99%

Do cystic vestibular schwannomas have worse surgical outcomes? Systematic analysis of the literature

Thakur¹,

Khan²,

Shorter³

et al. 2012

FOC

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Object The goal of this study was to perform a systematic quantitative comparison of the surgical outcomes between cystic vestibular schwannomas (CVSs) and solid vestibular schwannomas (SVSs). Methods A review of English-language literature published between 1990 and 2011 was performed using various search engines including PubMed, Google Scholar, and the Cochrane database. Only studies that reported surgical results of CVSs in comparison with SVSs were included in the analysis. The primary end point of this study was surgical outcomes, defined by the following: 1) facial nerve outcomes at latest follow-up; 2) mortality rates; or 3) non–facial nerve complication index. Secondary end points included extent of resection and brainstem adherence. Results Nine studies comprising 428 CVSs and 1287 SVSs were included in the study. The mean age of patients undergoing surgery was 48.3 ± 6.75 and 47.1 ± 9 years for CVSs and SVSs, respectively (p = 0.8). The mean tumor diameter for CVSs was 3.9 ± 0.84 cm and that for SVSs was 3.7 ± 1.2 cm (p = 0.7). There was no significant difference in the extent of resection among CVSs and SVSs (81.2% vs 80.7%, p = 0.87) Facial nerve outcomes were significantly better in the cohort of patients with SVSs than in those with CVSs (52.1% vs 39%, p = 0.0001). The perioperative mortality rates for CVSs and SVSs were not significantly different (3% and 3.8%, respectively; p = 0.6). No significant difference was noted between the cumulative non–facial nerve complication rate (including mortality) among patients with CVSs and SVSs (24.5% and 25.6%, respectively; p = 0.75) Conclusions Facial nerve outcomes are worse in patients undergoing resection for CVSs than in patients undergoing resection for SVSs. There were no significant differences in the extent of resection or postoperative morbidity and mortality rates between the cohorts of patients with vestibular schwannomas.

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Molecular Genetic Analysis of the Mechanism of Tumorigenesis in Acoustic Neuroma

Irving¹,

Moffat²,

Hardy³

et al. 1993

Archives of Otolaryngology - Head and Neck Surgery

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The proliferative activity of neurilemomas

Cited by 23 publications

References 17 publications

Long-term follow-up of the residual intracanalicular tumours after subtotal removal of acoustic neurinomas

Long-term follow-up of the residual intracanalicular tumours after subtotal removal of acoustic neurinomas

Do cystic vestibular schwannomas have worse surgical outcomes? Systematic analysis of the literature

Molecular Genetic Analysis of the Mechanism of Tumorigenesis in Acoustic Neuroma

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