The Proliferating Cell Nuclear Antigen Index in Breast Aarcinomas does not Correlate with Mitotic Index and Estrogen Receptor Immunoreactivity

Schmitt, Fernando; Pereira, Ester Miranda; Andrade, Larissa Mara de; Torresan, M.; Lucca, Leidiane de

doi:10.1016/s0344-0338(11)80426-7

Cited by 10 publications

(7 citation statements)

References 22 publications

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“…On the other hand, the presence of PCNA-positive cells outside the basal layer (in the G0 phase) was probably one reason for the higher PCNA expression in the control group than in the OSCC, as observed in this study (6). In fact, not all studies have confirmed the correlation between PCNA expression and proliferation, mitotic activity and Ki-67 proliferative labeling index (21). This is probably because PCNA is also involved in DNA repair.…”

Section: Discussionmentioning

confidence: 55%

Analysis of cell proliferation and pattern of invasion in oral squamous cell carcinoma

Watanabe

Oton-Leite

et al. 2010

J Oral Sci

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Cell proliferation markers play an important role in the biological behavior of neoplasms. This study investigated the immunohistochemical expression of PCNA, Ki-67 and Cyclin B1 proteins based on the pattern of cell invasion in oral squamous cell carcinoma (OSCC). A total of 39 OSCC specimens and 13 samples of normal oral mucosa (control) were immunohistochemically analyzed. Protein expression was evaluated according to World Health Organization - Histological Malignancy Grading (WHO-HMG) and a specific grading system for invasion, graded from 1 to 4, varying from a consistently well-defined "pushing" border to diffuse infiltration and cellular dissociation, and was then correlated with clinical features. We found higher expression of Ki-67 and Cyclin B1 in OSCC when compared with the control group. High Ki-67 expression levels were more commonly seen in the floor of the mouth than in the tongue (P = 0.009). Cyclin B1 showed a positive correlation with histological grade, according to WHO-HMG criteria (P = 0.01). Our results suggest that Cyclin B1 is a reliable proliferation marker for indicating degree of tumor proliferation. Correlations between PCNA, Ki-67, Cyclin B1 and invasive tumor front with overall survival were not observed. Further studies are needed in order to elucidate whether cell proliferation activity at the tumor invasion front is related to prognosis.

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Section: Discussionmentioning

confidence: 55%

Analysis of cell proliferation and pattern of invasion in oral squamous cell carcinoma

Watanabe

Oton-Leite

et al. 2010

J Oral Sci

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“…16,39 Thus, PCNA may not be a good proliferation marker in human breast carcinomas. 32 In contrast, in a few studies PCNA appeared to be an independent factor affecting DFS and OS in univariate or multivariate analyses. 20,36,38 The only published multivariate analysis of survival of dogs with malignant CMT 22 indicated that increased age, elevated S-phase fraction, and ploidy status were independent predictors of survival.…”

Section: Discussionmentioning

confidence: 89%

Immunohistochemical Detection of Ki-67 and PCNA in Canine Mammary Tumors: Relationship to Clinical and Pathologic Variables

et al. 1998

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The objectives of this study were to measure the proliferation indices in canine mammary tumors using immunohistochemical detection of Ki-67 and proliferating cell nuclear antigen (PCNA), to determine the relationship of these antigens to clinical and pathologic variables, and to investigate the usefulness of these antigens as prognostic indicators. Ninety-six female dogs with 115 primary nonmetastasized spontaneous mammary tumors and dysplasias were included in the study. Immunostaining was performed using MIB-1 and PC10 monoclonal antibodies against Ki-67 and PCNA, respectively. Ki-67 and PCNA proliferation indices were determined. Dogs were followed for 18 months, with clinical examinations every 3-4 months. There was a significant correlation between Ki-67 and PCNA indices in the dogs with dysplasias and benign tumors but not in the dogs with malignant tumors. The clinical stage at first presentation was related to the proliferative index measured with Ki-67 but not to that measured with PCNA. Proliferation indices were significantly lower in the nonmalignant tumors and dysplasias than in the malignant tumors. In malignant tumors, the PCNA index had a positive correlation with the histologic malignant grade and the nuclear grade. High index values of Ki-67 were positively correlated with metastasis, death from neoplasia, low disease-free survival rates, and low overall survival rates. PCNA displayed no significant association with these variables. Multivariate analyses concerning metastasis, disease-free survival, and overall survival revealed that the Ki-67 index had prognostic value.

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“…Expression of PCNA correlates partly with other proliferation markers such as %S-phase fraction, [31][32][33] Ki67 staining, 34 and mitotic count. 32 Not all studies, however, have confirmed the correlation with mitotic count, 35 and the PCNA labelling index could not be correlated with the Ki67 labelling index. 36 This is probably owing to the fact that PCNA is also involved in DNA repair.…”

Section: Associated Antigensmentioning

confidence: 98%

Proliferation markers in tumours: interpretation and clinical value.

Diest¹,

Brugal²,

Baak³

1998

J Clin Pathol

178

124

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The Proliferating Cell Nuclear Antigen Index in Breast Aarcinomas does not Correlate with Mitotic Index and Estrogen Receptor Immunoreactivity

Cited by 10 publications

References 22 publications

Analysis of cell proliferation and pattern of invasion in oral squamous cell carcinoma

Analysis of cell proliferation and pattern of invasion in oral squamous cell carcinoma

Immunohistochemical Detection of Ki-67 and PCNA in Canine Mammary Tumors: Relationship to Clinical and Pathologic Variables

Proliferation markers in tumours: interpretation and clinical value.

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