The prolactin receptor (PRLR) gene is linked to and associated with the comorbidity of depression and type 2 diabetes in Italian families

Amin, Mutaz; Wu, Rongling; Postolache, Teodor T.; Gragnoli, Claudia

doi:10.1016/j.gendis.2023.06.018

Cited by 6 publications

(3 citation statements)

References 5 publications

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“…Melatonin membrane receptors, specifically MTNR1A and MTNR2, are found in testicular and epididymal tissue (Zhang et al, 2022). Notably, MTNR1A gene polymorphism has been closely linked to various diseases, including oral cancer, polycystic ovary syndrome, type 2 diabetes, and Alzheimer's disease (Lin et al, 2015;Sulkava et al, 2018;Yi et al, 2020;Amin and Gragnoli, 2023). Downregulation of MTNR1A can result in decreased testosterone levels within the testes, impacting normal physiological function (Gao et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Melatonin alleviates oxidative stress damage in mouse testes induced by bisphenol A

Qi,

Yang,

et al. 2024

Front. Cell Dev. Biol.

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We investigated the effect of melatonin on bisphenol A (BPA)-induced oxidative stress damage in testicular tissue and Leydig cells. Mice were gavaged with 50 mg/kg BPA for 30 days, and concurrently, were injected with melatonin (10 mg/kg and 20 mg/kg). Leydig cells were treated with 10 μmol/L of BPA and melatonin. The morphology and organ index of the testis and epididymis were observed and calculated. The sperm viability and density were determined. The expressions of melatonin receptor 1A and luteinizing hormone receptor, and the levels of malonaldehyde, antioxidant enzymes, glutathione, steroid hormone synthases, aromatase, luteinizing hormone, testosterone, and estradiol were measured. TUNEL assay was utilized to detect testicular cell apoptosis. The administration of melatonin at 20 mg/kg significantly improved the testicular index and epididymis index in mice treated with BPA. Additionally, melatonin promoted the development of seminiferous tubules in the testes. Furthermore, the treatment with 20 mg/kg melatonin significantly increased sperm viability and sperm density in mice, while also promoting the expressions of melatonin receptor 1A and luteinizing hormone receptor in Leydig cells of BPA-treated mice. Significantly, melatonin reduced the level of malonaldehyde in testicular tissue and increased the expression of antioxidant enzymes (superoxide dismutase 1, superoxide dismutase 2, and catalase) as well as the content of glutathione. Moreover, melatonin also reduced the number of apoptotic Leydig cells and spermatogonia, aromatase expression, and estradiol level, while increasing the expression of steroid hormone synthases (steroidogenic acute regulatory protein, cytochrome P450 family 17a1, cytochrome P450 17α-hydroxylase/20-lyase, and, 17β-hydroxysteroid dehydrogenase) and the level of testosterone. Melatonin exhibited significant potential in alleviating testicular oxidative stress damage caused by BPA. These beneficial effects may be attributed to melatonin’s ability to enhance the antioxidant capacity of testicular tissue, promote testosterone synthesis, and reduce testicular cell apoptosis.

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Section: Discussionmentioning

confidence: 99%

Melatonin alleviates oxidative stress damage in mouse testes induced by bisphenol A

Qi,

Yang,

et al. 2024

Front. Cell Dev. Biol.

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show abstract

“…Additionally, two genes, MTNR1A and MTNR1B, have been identified, which are implicated in animal reproductive processes and the regulation of animal coat color. Research has demonstrated that MTNR1A may facilitate melatonin synthesis, whereas MTNR1B has the converse effect [38,39]. By regulating the activity of tyrosine hydroxylase, MTNR1A and MTNR1B can affect the synthesis and dispersion of melatonin, ultimately influencing skin color.…”

Section: Plos Onementioning

confidence: 99%