The prolactin receptor: A cross‐species comparison of gene structure, transcriptional regulation, tissue‐specificity, and genetic variation
Carmen M. Banks,
Josephine F. Trott,
Russell C. Hovey
Abstract:The conserved and multifaceted functions of prolactin (PRL) are coordinated through varied distribution and expression of its cell‐surface receptor (PRLR) across a range of tissues and physiological states. The resultant heterogeneous expression of PRLR mRNA and protein across different organs and cell types supports a wide range of PRL‐regulated processes including reproduction, lactation, development, and homeostasis. Genetic variation within the PRLR gene also accounts for several phenotypes impacting agric… Show more
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