The Progress of Anti-HBV Constituents from Medicinal Plants in China

Geng, Chang‐An; Chen, Ji‐Jun

doi:10.1007/s13659-018-0178-6

Cited by 11 publications

(9 citation statements)

References 53 publications

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“…The root bark of Illicium henryi Diels (Illiciaceae), commonly known as Chinese anise tree or hardwood crab, has been used for alleviating pain and swelling, removing phlegm, promoting blood circulation, and dispelling pathogenic wind, cold and dampness in traditional Chinese medicine [18,19]. Modern pharmacological studies have shown that this drug possesses anti-inflammatory, antioxidant, anti-hepatitis B virus, and anti-HIV activities [20,21]. The root bark of I. henryi has been reported to contain flavonoids, prenylated C6–C3 compounds, sesquiterpene lactones, triterpenoids, lignans, and neolignans [18,22,23].…”

Section: Introductionmentioning

confidence: 99%

Ethanol Extract of Illicium henryi Attenuates LPS-Induced Acute Kidney Injury in Mice via Regulating Inflammation and Oxidative Stress

Islam

Miao

et al. 2019

Nutrients

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The root bark of Illicium henryi has been used in traditional Chinese medicine to treat various diseases. Its ethanol extract (EEIH) was found to contain a large number of phenols and possess in vitro antioxidant activities. The present study aimed to investigate its protective effect against lipopolysaccharide (LPS)-induced acute kidney injury (AKI) in mice. BALB/c mice were intraperitoneally pretreated with EEIH for five days, and then LPS injection was applied to induce AKI. Blood samples and kidney tissues were collected and used for histopathology, biochemical assay, enzyme-linked immunosorbent assay (ELISA), quantitative real-time polymerase chain reaction (qRT-PCR), and Western blot analyses. EEIH not only significantly dose-dependently attenuated histological damage and reduced renal myeloperoxidase (MPO) activity (from 9.77 ± 0.73 to 0.84 ± 0.30 U/g tissue) but also decreased serum creatinine (from 55.60 ± 2.70 to 27.20 ± 2.39 µmol/L) and blood urea nitrogen (BUN) (from 29.95 ± 1.96 to 16.12 ± 1.24 mmol/L) levels in LPS-treated mice. EEIH also markedly dose-dependently inhibited mRNA expression and production of TNF-α (from 140.40 ± 5.15 to 84.74 ± 5.65 pg/mg), IL-1β (from 135.54 ± 8.20 to 77.15 ± 5.34 pg/mg), IL-6 (from 168.74 ± 7.23 to 119.16 ± 9.35 pg/mg), and COX-2 in renal tissue of LPS-treated mice via downregulating mRNA and protein expressions of toll-like receptor 4 (TLR4) and phosphorylation of nuclear factor-κB (NF-κB) p65. Moreover, EEIH significantly dose-dependently reduced malondialdehyde (MDA) (from 5.43 ± 0.43 to 2.80 ± 0.25 nmol/mg prot) and NO (from 1.01 ± 0.05 to 0.24 ± 0.05 µmol/g prot) levels and increased superoxide dismutase (SOD) (from 22.32 ± 2.92 to 47.59 ± 3.79 U/mg prot) and glutathione (GSH) (from 6.57 ± 0.53 to 16.89 ± 0.68 µmol/g prot) levels in renal tissue induced by LPS through upregulating mRNA expression of nuclear factor erythroid 2 related factor 2 (Nrf2). Furthermore, EEIH inhibited LPS-induced intracellular reactive oxygen species (ROS) production from RAW264.7 cells in a concentration-dependent manner. These results suggest that EEIH has protective effects against AKI in mice through regulating inflammation and oxidative stress.

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Section: Introductionmentioning

confidence: 99%

Ethanol Extract of Illicium henryi Attenuates LPS-Induced Acute Kidney Injury in Mice via Regulating Inflammation and Oxidative Stress

Islam

Miao

et al. 2019

Nutrients

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“…17 It has also been postulated that some medicinal plants used in Traditional Chinese Medicine exhibit anti-HBV activity. 13 Several plants native to the Arabian Peninsula: Guiera senegalensis, Pulicia crispa, Coccinea grandis, Fumaria parviflora, Capparis decidua, Corallocarpus epigeus, Indigofera caerulea, Abutilon figarianum and Acacia oerfota have also been found to possess anti-HBV activity by inhibiting hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) in the cell culture supernatant. 18 Our previous study also reported that Cananga odorata exhibited strong inhibition of the hepatitis B virus in Hep38.7-Tet and HepG2-NTCP cells.…”

Section: Discussionmentioning

confidence: 99%

“…It has also been reported that piperine and guineesine, isolated compounds of Piper longum, exhibit inhibitory activity suppressing the secretion of HBsAg and HBeAg with IC 50 values of 0.15 and 0.05 mM for HBsAg, and 0.14 and 0.05 mM for HBeAg, respectively. 13 Our previous study was reported Cananga odorata possessed a strong anti-HBV activity both in HepG2-NTCP and Hep38.7-Tet cells which indicated the action of extract in the entry and post entry steps (replication) of HBV life cycle. 14 In this study, we screened 31 samples of Indonesian medicinal plants for anti-HBV activity by two invitro assays to assess the effect on the viral entry and replication.…”

Section: Introductionmentioning

confidence: 91%

Antiviral Activity of Indonesian Medicinal Plants against Hepatitis B Virus

Wahyuni¹,

Permanasari²,

Widyawaruyanti³

et al. 2020

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Background: Hepatitis B virus (HBV) infects more than 300 million people globally and is a common cause of liver cancer. Current therapy using reverse transcriptase inhibitors require long-term treatment and the potential risk of development of drug-resistant viruses remains an important issue to be considered. Hence, the development of new drugs is critical. Traditional medicinal plants used for the treatment of infectious diseases may provide a viable option for the discovery of anti-HBV drug candidates. Objective: This study examined anti-HBV activity of 31 kinds of Indonesian plants. Materials and Methods: Crude extracts of various part of plants, leaves and stem, were obtained using dichloromethane and ethanol solvent. The effect on viral entry was examined by determining levels of HBsAg expression in the supernatants of HBV-infected HepG2-NTCP cells by ELISA. The effect on HBV replication was determined by measuring HBV DNAs amounts in Hep38.7-Tet cells by quantitative real-time PCR. Results: The extracts of Phyllantus niruri leaves and Curcuma xanthorrhiza showed reduction of strong HBsAg production from HepG2-NTCP cells with IC 50 values of 170.48 and 270.51 μg/mL, respectively. Treatment of HepAD38.7-Tet cells with P. niruri and C. xanthorhiza at the highest concentration while avoiding cytotoxicity reduced extracellular HBV DNA levels by 70% and 30 % of the untreated control respectively. Conclusion: P. niruri inhibited both the entry and HBV replication, thus P. niruri is a promising candidate for anti-HBV drug development.

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“…The plant possesses several bioactive compounds, including xanthones, flavonoids, triterpenoids, alkaloids, which have been shown to be effective as anti-oxidant, antibacterial, antifungal, and antiviral. 98,101,102 The bioactive compounds that inhibit 3CLpro, making them valuable against CoVs, are Kouitchenside and Oleanolic acid. 24 Other species in Swertia genus with potential anti-SARS CoV activity include Swertia binchuanensis, Swertia macrosperma, Swertia maculate, Swertia mussotii.…”

Section: Camellia Sinensismentioning

confidence: 99%

Medicinal Plants with Potential Inhibitory Bioactive Compounds against Coronaviruses

et al. 2021

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Medicinal plant is a major source of drug discovery for disease management. Over 85% of the population in Asia and in the Middle East use herbal medicine for disease management such as SARS caused by coronavirus. Infection from coronavirus is initiated by entry of the virus into a susceptible host cell. The two human coronaviruses of public health importance two decades ago were SARS-CoV and MERS-CoV and now SARS-CoV 2. These three viruses belong to the same class of beta coronavirus and are somewhat similar in genome sequencing, life cycle, mode of entry into a host, mode of transmission and clinical manifestations. This review identified twenty medicinal plants with potential inhibitory bioactive compounds from natural sources that are active against coronaviruses that could be developed into various drug delivery systems. It also highlighted several evidences to show that medicinal plant used in the treatment of SARS-CoV may offer some sort of relief from the burden of COVID 19 pandemic. Since there is no specific treatment for COVID 19 yet, the search for medicinal plants with inhibitory bioactive compounds against coronavirus could be the long awaited breakthrough scientists have been searching to change the narratives of Covid-19 pandemic.

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The Progress of Anti-HBV Constituents from Medicinal Plants in China

Cited by 11 publications

References 53 publications

Ethanol Extract of Illicium henryi Attenuates LPS-Induced Acute Kidney Injury in Mice via Regulating Inflammation and Oxidative Stress

Ethanol Extract of Illicium henryi Attenuates LPS-Induced Acute Kidney Injury in Mice via Regulating Inflammation and Oxidative Stress

Antiviral Activity of Indonesian Medicinal Plants against Hepatitis B Virus

Medicinal Plants with Potential Inhibitory Bioactive Compounds against Coronaviruses

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