The progress in quantitative evaluation of callus during distraction osteogenesis

Liu, Qi; Liu, Ze; Guo, Haipeng; Liang, Jieyu; Zhang, Yi

doi:10.1186/s12891-022-05458-8

Cited by 6 publications

(38 citation statements)

References 93 publications

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“…À medida que a densidade do osso regenerado aumenta com a cicatrização, seu valor de pixel fica próximo ao do osso normal adjacente. 26,27 O valor de cinza (VC) é outro indicador usado para avaliar a cicatrização óssea. Uma imagem em tons de cinza é uma matriz de dados.…”

Section: Valores De Pixels Em Radiologia Digitalunclassified

“…4,17,26 Todavia, por se tratar de método matemático com base em imagens obtidas por radiologia digital, a técnica de valor de pixel compartilha das limitações encontradas na radiologia convencional para avaliação do regenerado em suas fases iniciais. 26 Ultrassonografia O princípio do uso da ultrassonografia na avaliação do regenerado é o de que sinais de atenuação ultrassônica de banda larga podem ser empregados para avaliar a alteração da DMO. Quando o ultrassom passa pelo tecido corporal, ocorre a atenuação, cuja quantidade está relacionada às características do tecido.…”

Section: Valores De Pixels Em Radiologia Digitalunclassified

“…Contudo, o seu alto custo e a sua baixa disponibilidade relativa limitam a sua aplicabilidade clínica em larga escala. 17,26 Cintilografia Óssea A cintilografia óssea trifásica é um método não invasivo para avaliar alterações no fluxo sanguíneo, a distribuição sanguínea e o metabolismo ósseo de forma semiquantitativa. Considera-se que o suprimento sanguíneo tem íntima relação com a capacidade de produção do regenerado na osteogênese por distração.…”

Section: Densitometria óSsea Por Dexaunclassified

“…32 Ultrasonography is a non-invasive, effective, inexpensive, and ionizing radiation-free method to assess bone healing. It can detect new bone formation four to six weeks before radiography, 26 and it indicates the rate of formation of new bone in the early stages of distraction. 33 Therefore, early assessment is best performed by ultrasound, which enables the detection of unmineralized osteoid and the presence of any defects in the callus.…”

Section: Ultrasoundmentioning

confidence: 99%

“…It provides a high-precision, low-error assessment, making it an excellent method to determine BMD changes over time. 26 Quantitative computed tomography relies on the differences in the absorption of ionizing radiation by different tissues, enabling the comparison of attenuation measurements with standard reference values to determine parameters such as the BMC and BMD. 37 In addition, QCT can use three-dimensional images to assess the bone callus, for it enables performance of a finite element analysis to predict bone callus strength, with applications in musculoskeletal research.…”

Section: Quantitative Computed Tomographymentioning

confidence: 99%

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Métodos de avaliação do regenerado ósseo

Cardoso,

Amorim

2024

Rev Bras Ortop (Sao Paulo)

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ResumoDesde que foi descrita por Ilizarov, a técnica de osteogênese por distração tem sido utilizada para o tratamento de diversas condições relacionadas ao trauma, infecções, tumores ósseos e doenças congênitas, na forma de transporte ou alongamento ósseo. Um dos dilemas mais comuns do cirurgião ortopédico que realiza distração osteogênica é o estabelecimento de um método reprodutível de verificação da progressão da osteogênese, que permita a detecção precoce de falhas no regenerado, para que se possa interferir de forma eficaz durante o tratamento, bem como determinar o tempo apropriado de remoção do fixador externo. Recentemente, vários métodos de monitoramento quantitativo, com os quais se poderia avaliar a recuperação da estrutura e as propriedades biomecânicas do regenerado ósseo em diferentes estágios, além do processo de cicatrização óssea, têm sido amplamente investigados. Por esses métodos, pode-se saber o conteúdo mineral ósseo, a densidade mineral óssea, a rigidez e o metabolismo ósseo. Nesta revisão, resumimos de forma abrangente as técnicas mais recentes para avaliar a cicatrização óssea durante a distração osteogênica, entre elas, métodos como a radiografia convencional e os valores de pixels em radiologia digital, a ultrassonografia, a densitometria e a cintilografia ósseas, a tomografia computadorizada quantitativa, a avaliação biomecânica, os marcadores bioquímicos e os modelos matemáticos. Consideramos fundamental o conhecimento dos diversos métodos à disposição atualmente e entendemos que a utilização de vários métodos de monitoramento simultaneamente possa ser uma solução ideal, que aponte para uma direção futura no seguimento da distração osteogênica.

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Section: Valores De Pixels Em Radiologia Digitalunclassified

Section: Densitometria óSsea Por Dexaunclassified

Section: Ultrasoundmentioning

confidence: 99%

Section: Quantitative Computed Tomographymentioning

confidence: 99%

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Métodos de avaliação do regenerado ósseo

Cardoso,

Amorim

2024

Rev Bras Ortop (Sao Paulo)

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A comparative study of bone union and nonunion during distraction osteogenesis

Liu

Guo

et al. 2022

BMC Musculoskelet Disord

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Background The clinical characteristics of bone nonunion during distraction osteogenesis (DO) were rarely discussed. This study was employed to specify the difference between bone union and nonunion during DO. Methods The patients with bone lengthening were recruited in our study. The bone union cases indicated the ones that remove the external fixator successfully, whereas the bone nonunion represented the bridging callus did not appear even after 9 months (an absence of bridging callus for at least three out of four cortices on plain radiographs) that needs autogenous bone transplantation. The differences in the pixel value ratio (PVR) growth of regenerated callus, lengthening index (LI), healing index (HI), external fixation index (EFI) and blood biochemical indexes between bone union and nonunion were analyzed. Results A total of 8 bone nonunion and 27 bone union subjects were included in this study. The PVR growth in bone nonunion was significantly lower than that in bone union (0.19 ± 0.06 vs. 0.32 ± 0.16, P = 0.048). Interestingly, the HI and EFI in bone nonunion was significantly higher than that in bone union (62.0 ± 31.4 vs. 37.0 ± 27.4, P = 0.036; 75.0 ± 30.9 vs. 49.9 ± 16.1, P = 0.006). However, no significant difference with regard to LI was identified (0.76 ± 0.52 vs. 0.77 ± 0.32, P = 0.976). Moreover, the circulating level of urea and lymphocyte count in bone union was significantly lower than that in bone nonunion (4.31 ± 1.05 vs. 5.17 ± 1.06, P = 0.049; 2.08 ± 0.67 vs. 2.73 ± 0.54, P = 0.018). On the contrary, the circulating level of magnesium in bone union was significantly higher than that in bone nonunion (0.87 ± 0.07 vs. 0.80 ± 0.07, P = 0.014). Conclusion Compared to the bone union, the PVR growth was significantly lower, whereas the HI and EFI was significantly higher in the bone nonunion. Moreover, the circulating level of urea, magnesium and lymphocyte count was also different between these two. Therefore, the PVR, HI and EFI seems to be reliable and sensitive indicators to reflect the bone nonunion during DO, which might be considered in bone lengthening. Further prospective studies are still needed to elaborate the concerned issues.

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Experimental study on determining the degree of bone healing by wall thickness ratio analysis

Tong,

Yang,

Dai

et al. 2024

J Orthop Surg Res

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To verify the reliability and accuracy of wall thickness ratio analysis to determine the degree of bone healing, fracture models were established with 6 beagles. X-ray, micro-CT, and CT scans were performed at 24 weeks. The healthy side and the affected side were used to simulate the three-dimensional geometric model after internal fixation, and the mesh was divided. The mean and median CT wall thickness values were obtained through the wall thickness analysis. X-ray, CT, micro-CT, and gross appearance were used to determine the degree of bone healing, which was compared with wall thickness analysis. There was a positive correlation between the average CT value and the median wall thickness. The correlation coefficient analysis of the median wall thickness ratio (R2) and healing index ratio (R3) showed a positive correlation. The results of the wall thickness ratio (R2) and the healing index ratio (R3) were used to determine bone healing, and the results were consistent with the results of the actual mechanical test and image analysis. The results of wall thickness ratio analysis were significantly correlated with the degree of bone healing. This method is simple, rapid, and practical to analyze and judge the degree of bone healing.

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The progress in quantitative evaluation of callus during distraction osteogenesis

Cited by 6 publications

References 93 publications

Métodos de avaliação do regenerado ósseo

Métodos de avaliação do regenerado ósseo

A comparative study of bone union and nonunion during distraction osteogenesis

Experimental study on determining the degree of bone healing by wall thickness ratio analysis

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