The progress in corneal translational medicine

Hancox, Zoe; Keshel, Saeed Heidari; Yousaf, Safiyya; Saeinasab, Morvarid; Shahbazi, Mohammad‐Ali; Sefat, Farshid

doi:10.1039/d0bm01209b

Cited by 22 publications

(17 citation statements)

References 265 publications

(287 reference statements)

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“…Some of these kinds of biodegradable polymers have shown that threedimensional scaffolds can allow the diffusion of nutrients and also support cell adhesion, proliferation and differentiation for functional tissue regeneration [12][13][14]. More precisely, a good amount of research has been conducted by different researchers globally using various polymeric and synthetic biomaterials for many applications within the human body which mainly have used electrospinning technique including in the breast [15], bone [16,17], nerves [18], dental [19,20], skin [21][22][23], cornea and contact lenses [24][25][26][27][28][29][30], blood vessels [31], ligaments [32], diaphragm [33], trachea [34,35], lung [36], cartilage [37], bladder [38] and intestine [39], and all of the mentioned tissues have involved the same principle.…”

Section: Introductionmentioning

confidence: 99%

Degradation and Characterisation of Electrospun Polycaprolactone (PCL) and Poly(lactic-co-glycolic acid) (PLGA) Scaffolds for Vascular Tissue Engineering

Bazgir

Zhang

et al. 2021

Materials

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The current study aimed to evaluate the characteristics and the effects of degradation on the structural properties of poly(lactic-co-glycolic acid) (PLGA)-and polycaprolactone (PCL)-based nanofibrous scaffolds. Six scaffolds were prepared by electrospinning, three with PCL 15% (w/v) and three with PLGA 10% (w/v), with electrospinning processing times of 30, 60 and 90 min. Both types of scaffolds displayed more robust mechanical properties with increased spinning times. The tensile strength of both scaffolds with 90-min electrospun membranes did not show a significant difference in their strengths, as the PCL and PLGA scaffolds measured at 1.492 MPa ± 0.378 SD and 1.764 MPa ± 0.7982 SD, respectively. All membranes were shown to be hydrophobic under a wettability test. A degradation behaviour study was performed by immersing all scaffolds in phosphate-buffered saline (PBS) solution at room temperature for 12 weeks and for 4 weeks at 37 °C. The effects of degradation were monitored by taking each sample out of the PBS solution every week, and the structural changes were investigated under a scanning electron microscope (SEM). The PCL and PLGA scaffolds showed excellent fibre structure with adequate degradation, and the fibre diameter, measured over time, showed slight increase in size. Therefore, as an example of fibre water intake and progressive degradation, the scaffold’s percentage weight loss increased each week, further supporting the porous membrane’s degradability. The pore size and the porosity percentage of all scaffolds decreased substantially over the degradation period. The conclusion drawn from this experiment is that PCL and PLGA hold great promise for tissue engineering and regenerative medicine applications.

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Section: Introductionmentioning

confidence: 99%

Degradation and Characterisation of Electrospun Polycaprolactone (PCL) and Poly(lactic-co-glycolic acid) (PLGA) Scaffolds for Vascular Tissue Engineering

Bazgir

Zhang

et al. 2021

Materials

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“…[ 171 ] Clinical assessment of novel bioengineered stromal constructs is limited. [ 172 ] Animal trials performed have been discussed throughout this text, with varying degrees of success. The latest stromal constructs on the market, such as the CorNeat KPro, focus on 100% synthetic, nonbiodegradable materials in a similar way to the established Boston KPro.…”

Section: Discussionmentioning

confidence: 99%

Mechanical Properties of Bioengineered Corneal Stroma

Formisano

Putten

Grant

et al. 2021

Adv Healthcare Materials

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For the majority of patients with severe corneal injury or disease, corneal transplantation is the only suitable treatment option. Unfortunately, the demand for donor corneas greatly exceeds the availability. To overcome shortage issues, a myriad of bioengineered constructs have been developed as mimetics of the corneal stroma over the last few decades. Despite the sheer number of bioengineered stromas developed , these implants fail clinical trials exhibiting poor tissue integration and adverse effects in vivo. Such shortcomings can partially be ascribed to poor biomechanical performance. In this review, existing approaches for bioengineering corneal stromal constructs and their mechanical properties are described. The information collected in this review can be used to critically analyze the biomechanical properties of future stromal constructs, which are often overlooked, but can determine the failure or success of corresponding implants.

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“…Unlike other engineered tissues, the artificial cornea must have excellent optical transparency to admit light [120] , [121] , [122] , [123] . The human amniotic membrane is most widely used because it contains growth factors with low immunogenicity [124] , [125] , [126] , but its transparency is poor due to its thick seroma layer (shown in Fig. 6 b).…”

Section: Tissue Engineeringmentioning

confidence: 99%