The progress and prospect of natural components in rhubarb (Rheum ribes L.) in the treatment of renal fibrosis

Abstract

Background: Renal fibrosis is a key pathological change that occurs in the progression of almost all chronic kidney diseases . CKD has the characteristics of high morbidity and mortality. Its prevalence is increasing each year on a global scale, which seriously affects people’s health and quality of life. Natural products have been used for new drug development and disease treatment for many years. The abundant natural products in R. ribes L. can intervene in the process of renal fibrosis in different ways and have considerable therapeutic prospects.Purpose: The etiology and pathology of renal fibrosis were analyzed, and the different ways in which the natural components of R. ribes L. can intervene and provide curative effects on the process of renal fibrosis were summarized. Methods: Electronic databases, such as PubMed, Life Science, MEDLINE, and Web of Science, were searched using the keywords ‘R. ribes L.’, ‘kidney fibrosis’, ‘emodin’ and ‘rhein’, and the various ways in which the natural ingredients protect against renal fibrosis were collected and sorted out.Results: We analyzed several factors that play a leading role in the pathogenesis of renal fibrosis, such as the mechanism of the TGF-β/Smad and Wnt/β-catenin signaling pathways. Additionally, we reviewed the progress of the treatment of renal fibrosis with natural components in R. ribes L. and the intervention mechanism of the crucial therapeutic targets.Conclusion: The natural components of R. ribes L. have a wide range of intervention effects on renal fibrosis targets, which provides new ideas for the development of new anti-kidney fibrosis drugs.

Huangqi-Guizhi-Wuwu Decoction in the Treatment of Diabetic Nephropathy (CKD2-4): A Study Protocol for a Prospective, Open, Multicenter and Controlled Trail

“…This process also exists in the DN. Moreover, through clinical and animal experiments, it is clearly pointed out that [23]: collaterals are highly correlated with the capillary network and the surrounding environment, and it can be considered that the concept of renal fibrosis is related to the collaterals theory of TCM [24][25]. Therefore, we can conduct the treatment of promoting blood circulation and remove the blood stasis according to the theory of kidney complex disease.…”

The modulation of gut microbiota by herbal medicine to alleviate diabetic kidney disease – A review

“…The main official parts of Rheum palmatum L. are the root and rhizome. Research has shown that Rheum palmatum L. has several pharmacological properties such as anti-inflammatory, antioxidant, and most importantly, it protects against renal fibrosis ( Wang et al, 2022 ). Rheum palmatum L. can also decrease the abundance of conditionally pathogenic microbes such as Alcaligenaceae, Methanosphaera , and Clostridiaceae in the intestine of 5/6 Nephrectomy rats compared to the CKD model, restoring the functions of the intestinal barrier and alleviating renal fibrosis ( Ji et al, 2020 ).…”

Mechanism of Rhubarb and Agastache rugosa in the treatment of renal cell carcinoma based on network pharmacology and experimental validation

“…4 From the point of view of modern pharmacology, rhein and emodin are the effective components of Rhubarb, which have been proved to have a protective effect on the kidney. 5 Rhein has the pharmacological effect of anti-tumor and regulating renal function. 6 The pharmacological effects of emodin mainly include anti-cancer, anti-tumor and kidney protection, etc.…”