The prognostic values of tumor-infiltrating neutrophils, lymphocytes and neutrophil/lymphocyte rates in bladder urothelial cancer

Liu, Kangkang; Zhao, Kun; Wang, Lining; Sun, E

doi:10.1016/j.prp.2018.05.010

Cited by 63 publications

(75 citation statements)

References 31 publications

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“…T cells are one of the key players in antitumor immunity, due to their ability to selectively kill cancer cells. There is plenty of evidence on the prognostic value of T cells in BC (Table 1) [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. This is mainly derived from single-marker immunohistochemistry (IHC) studies in patients with localized BC, i.e., NMIBC and MIBC.…”

Section: Cd3 + and Cd8 + T Cellsmentioning

confidence: 99%

Prognostic and Predictive Value of Tumor-Infiltrating Immune Cells in Urothelial Cancer of the Bladder

Wilpe

Gerretsen

Heijden

et al. 2020

Cancers

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The prognosis and responsiveness to chemotherapy and checkpoint inhibitors differs substantially among patients with bladder cancer (BC). There is an unmet need for biomarkers that can accurately predict prognosis and treatment outcome. Here, we describe the available literature on the prognostic and predictive value of tumor-infiltrating immune cells in BC. Current evidence indicates that a high density of tumor-infiltrating CD8+ T cells is a favorable prognostic factor, whereas PD-L1 expression and tumor-associated macrophages are unfavorable prognostic features. While PD-L1 expression appears unsuccessful as a biomarker for the response to checkpoint inhibitors, there are some indications that high CD8+ T cell infiltration, low transforming growth factor-beta signaling and low densities of myeloid-derived suppressor cells are associated with response. Future studies should focus on combinations of biomarkers to accurately predict survival and response to treatment.

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Section: Cd3 + and Cd8 + T Cellsmentioning

confidence: 99%

Prognostic and Predictive Value of Tumor-Infiltrating Immune Cells in Urothelial Cancer of the Bladder

Wilpe

Gerretsen

Heijden

et al. 2020

Cancers

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“…On the contrary, very limited data are available on the clinical relevance of TAN. Liu et al recently showed that elevated CD66b + TAN correlate with an advanced T-stage, a high grade, a worse recurrence-free survival (RFS) within NMIBC subgroup and a worse overall survival (OS) within all UBC cases [36]. Moreover, Zhou et al have proposed that a high TAN score correlate with a poor OS [37].…”

Section: Discussionmentioning

confidence: 99%

“…On the contrary, works on TAN and UBCs are very limited. Elevated TANs have been correlated with poor prognosis [36], whereas a lower TANs density predict a better response to adjuvant chemotherapy [37]. However, studies adherent to analytical standards of immunoscore evaluation of TAN density, are still lacking [38].…”

Section: Introductionmentioning

confidence: 99%

Tumor Infiltrating Neutrophils Are Enriched in Basal-Type Urothelial Bladder Cancer

Mandelli

Missale

Bresciani

et al. 2020

Cells

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Background: Urothelial bladder cancers (UBCs) are distinct in two main molecular subtypes, namely basal and luminal type. Subtypes are also diverse in term of immune contexture, providing a rationale for patient selection to immunotherapy. Methods: By digital microscopy analysis of a muscle-invasive BC (MIBC) cohort, we explored the density and clinical significance of CD66b+ tumor-associated-neutrophils (TAN) and CD3+ T cells. Bioinformatics analysis of UBC datasets and gene expression analysis of UBC cell lines were additionally performed. Results: Basal type BC contained a significantly higher density of CD66b+ TAN compared to the luminal type. This finding was validated on TCGA, GSE32894 and GSE124305 datasets by computing a neutrophil signature. Of note, basal-type MIBC display a significantly higher level of chemokines (CKs) attracting neutrophils. Moreover, pro-inflammatory stimuli significantly up-regulate CXCL1, CXCL2 and CXCL8 in 5637 and RT4 UBC cell lines and induce neutrophil chemotaxis. In term of survival, a high density of T cells and TAN was significantly associated to a better outcome, with TAN density showing a more limited statistical power and following a non-linear predicting model. Conclusions: TAN are recruited in basal type MIBC by pro-inflammatory CKs. This finding establishes a groundwork for a better understanding of the UBC immunity and its relevance.

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“…Recently, the effect of tumor-infiltrating immune cells on BT prognosis has been the subject of research. It has been demonstrated that tumor-infiltrating neutrophils and NLR are negative predictors and tumor-infiltrating lymphocytes are positive predictors (29). Ethnicity has also been shown to affect NLR.…”

Section: Discussionmentioning

confidence: 99%

Can High Preoperative Neutrophil-lymphocyte Ratio Predict the Recurrence and Progression Risk of Non-muscle-invasive Bladder Tumors?

Kızılay¹,

Şimşir²

2019

uob

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Neutrophil-lymphocyte ratio (NLR) is a well-known, cost-effective biomarker of inflammatory conditions, and its protumor effect has been shown in different types of cancers. In this study, we aimed to evaluate the relationship between blood parameters, especially NLR, with the risk of progression and recurrence in non-muscle-invasive bladder tumors (NMIBT). Materials and Methods: Seventy-six patients were included in the study. Patients were divided into low, moderate and high-risk groups according to the risk of progression and recurrence. The preoperative blood parameters of the patients were recorded from the patient files and the NLR of each patient was calculated. These parameters were compared in terms of progression and recurrence risk groups. P values less than 0.05 were accepted statistically significant. Results: Neutrophil-lymphocyte ratio was significantly higher in the high-risk group in both the progression and recurrence risk groups than in the low and moderate risk groups (p<0.001). In addition, according to the post hoc results, the NLR values in the high-moderate and moderate-low risk groups showed significant differences (high-moderate and moderate-low values in terms of risk of recurrence were 4.66 vs 3.67 and 3.67 vs 2.88, respectively, p<0.001; high-moderate and moderate-low values in terms of risk of progression were 4.72 vs 3.68 and 3.68 vs 2.92, respectively, p<0.001). Conclusion: In our study, we found that groups with high risk of recurrence and progression had higher NLR values in patients with NMIBT. NLR, which is cheap, rapid and routinely applied in preoperative evaluation, is a promising biomarker in the prognostic classification of bladder tumors. Well-designed, large-scale prospective studies with long-term follow-up are needed to determine the role of NLR in this issue.

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The prognostic values of tumor-infiltrating neutrophils, lymphocytes and neutrophil/lymphocyte rates in bladder urothelial cancer

Cited by 63 publications

References 31 publications

Prognostic and Predictive Value of Tumor-Infiltrating Immune Cells in Urothelial Cancer of the Bladder

Prognostic and Predictive Value of Tumor-Infiltrating Immune Cells in Urothelial Cancer of the Bladder

Tumor Infiltrating Neutrophils Are Enriched in Basal-Type Urothelial Bladder Cancer

Can High Preoperative Neutrophil-lymphocyte Ratio Predict the Recurrence and Progression Risk of Non-muscle-invasive Bladder Tumors?

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