The prognostic values of the expression of Vimentin, TP53, and Podoplanin in patients with cervical cancer

Lin, Jiaying; Lü, Jiaqi; Wang, Chao; Xue, Xiangdong

doi:10.1186/s12935-017-0450-6

Cited by 22 publications

(18 citation statements)

References 37 publications

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“…After the investigation of the possible associations between the expression of vimentin and the classic prognostic factors for cervical cancer, as well as the survival of the patients, this hypothesis was not confirmed. Therefore, our results differ from those reported in previous studies such as (Cheng et al, 2012;Yu et al, 2015;Husain et al, 2016;Lin et al, 2017).…”

Section: Discussioncontrasting

confidence: 99%

“…The unusual expression of vimentina during reactivation of the EMT program in the invasion and metastasis process has already been investigated in several human tumors (Zhao et al, 2014;Holthoff et al, 2016;Figiel et al, 2017;Du et al, 2018). Regarding cervical cancer, there are still few studies evaluating the association of vimentin expression with prognostic aspects of tumors, especially with regard to survival and relapse-free interval evaluations Cheng et al, 2012;Yu et al, 2015;Husain et al, 2016;Lin et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

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Research Article Vimentin is not a reliable prognostic biomarker for cervical cancer

Santana¹,

Ramos²,

Nogueria³

et al. 2019

Genet. Mol. Res.

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clinical and pathological aspects, and to survival. Vimentin expression was observed in 100% of the tumor specimens. Hyperexpression of this biomarker in tumor cells (> 40%) was observed in 25% of the cases; however, it was not associated with clinical and pathological, or prognostic aspects of cervical cancer. Five-year survival for this group of patients was 66%; it was influenced by age, tumor size, presence of lymph node metastases, presence of distant metastases, and clinical stage. Hyperexpression of vimentin was not found to be a prognostic factor for cervical cancer.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Research Article Vimentin is not a reliable prognostic biomarker for cervical cancer

Santana¹,

Ramos²,

Nogueria³

et al. 2019

Genet. Mol. Res.

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show abstract

“…This is different from the findings of other studies. Lin et al (2017) showed in a multivariate analysis that Vimentin overexpression in cervical cancer patients was significantly associated with poor OS. The differences may be due to differences in sample size by analysis by the log-rank test in the previous study.…”

Section: Discussionmentioning

confidence: 99%

Combined Snail and E-cadherin Predicts Overall Survival of Cervical Carcinoma Patients: Comparison Among Various Epithelial-Mesenchymal Transition Proteins

Tian

Peng

Niu

et al. 2020

Front. Mol. Biosci.

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Background: Activation of Snail and synergistic loss of E-cadherin are hallmark features of the epithelial-mesenchymal transition (EMT), which contributes to the metastasis phenotype of epithelial cancer cells. However, the prognostic impact of Snail and of its combination with E-cadherin and with other EMT prognostic markers has not yet been systematically studied in cervical carcinoma. This study aimed to explore the prognostic value of combined Snail and E-cadherin in patients with cervical carcinoma and compared it to the prognostic value of other EMT prognostic markers. Methods: We retrospectively identified every initial diagnosis of cervical carcinoma among 203 patients treated at our hospital in China from January 2008 to March 2013. We examined the prognostic significance of Snail and other EMT protein markers, such as E-cadherin, Slug, ZEB1, Twist, Vimentin, and Survivin, by univariate and multivariate survival analyses. Results: Multivariate analyses showed that Snail and E-cadherin were significant biomarkers for overall survival (OS) in cervical carcinoma patients (HR, hazard ratio = 1.744, P = 0.036 and HR = 1.738, P = 0.047; respectively). Moreover, a combined index including Snail and E-cadherin showed enhanced prognostic value compared to that of Snail or E-cadherin alone. The present data demonstrate that Snail shows a negative correlation with E-cadherin (P < 0.001). High Snail expression and low E-cadherin expression were also more common in high tumor stages (P = 0.044 and P = 0.036; respectively), and lymph node metastasis (both P < 0.001). Moreover, Snail was a superior prognosis factor compared to Slug, ZEB1, Twist, Vimentin, and Survivin in cervical carcinoma. Conclusion: Based on our results, Snail and E-cadherin may be considered as independent prognosis markers, and the combination of Snail and E-cadherin might improve the OS prediction accuracy for patients with cervical carcinoma.

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“…Two pathologists evaluated the staining results independently. CK7, CK17 and podoplanin expressions were considered positive when there was immunoreaction in more than 10% of the tumor cells, as described in a previous study . Pathologists evaluated immunohistological staining independently and without access to clinical data.…”

Section: Methodsmentioning

confidence: 99%

Decreased cytokeratin 7 expression correlates with the progression of cervical squamous cell carcinoma and poor patient outcomes

Hashiguchi

Masuda

Kai

et al. 2019

J of Obstet and Gynaecol

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Aim: To identify potential biomarkers for tumor progression and patient outcomes in cervical squamous cell carcinoma. Methods: We examined the expressions of CK7 and CK17 as potential markers of the squamo-columnar junction, and podoplanin as a basal cell marker using surgical and biopsy samples of patients in grade 3 cervical intraepithelial neoplasia (n = 30), operable invasive carcinoma (OP group, n = 53) and inoperable invasive carcinoma before radiotherapy and/or chemotherapy (RC group, n = 76). Results: The positive rates of CK7 and podoplanin in invasive carcinoma were significantly lower than those in grade 3 cervical intraepithelial neoplasia (P = 0.001, P < 0.0001). The positive rates of CK7 and podoplanin in the RC group were significantly lower than those in the OP group (P < 0.0001, P = 0.04), while CK17 expression showed significantly higher positivity in the RC group than in the OP group (P < 0.0001). Negative CK7 expression showed a potential impact on overall survival in early-stage patients. In the RC group, the prevalence of cases with post-therapeutic residual carcinoma cells was higher in the CK7-negative group than in the positive group (P = 0.003). We found that decreased expression of CK7 could be a prognostic factor in early-stage cervical cancer patients. Conclusion: This result may provide strategies and suggestions for new treatment options and follow-up practices in managing patients with cervical cancer.

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The prognostic values of the expression of Vimentin, TP53, and Podoplanin in patients with cervical cancer

Cited by 22 publications

References 37 publications

Research Article Vimentin is not a reliable prognostic biomarker for cervical cancer

Research Article Vimentin is not a reliable prognostic biomarker for cervical cancer

Combined Snail and E-cadherin Predicts Overall Survival of Cervical Carcinoma Patients: Comparison Among Various Epithelial-Mesenchymal Transition Proteins

Decreased cytokeratin 7 expression correlates with the progression of cervical squamous cell carcinoma and poor patient outcomes

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