The prognostic values of matrix metalloproteinases in ovarian cancer

Zeng, Linchai; Qian, Jie; Zhu, Fangfang; Wu, Fang; Zhao, Hongqin; Zhu, Haiyan

doi:10.1177/0300060519825983

Cited by 30 publications

(62 citation statements)

References 30 publications

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“…Notably, we observed that MMP25 was the only one gene that not only significantly expressed compared to the normal tissues but also played a significant role in the survival outcome of head and neck cancer patients by analysis of Kaplan-Meier method and univariate Cox proportional hazards regression. Likewise, recent evidence also revealed that high MMP25 expression levels were correlated with a better overall survival in ovarian cancer (22). Clinicopathological features from TCGA cohort of head and neck cancer showed that high levels of MMP25 expression were correlated with patients' clinical stages in our study.…”

Section: Discussionsupporting

confidence: 83%

MMP25 Regulates Immune Infiltration Level and Survival Outcome in Head and Neck Cancer Patients

Liang

Guan

et al. 2020

Front. Oncol.

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Background: MMP25 is a critical gene of matrix metalloproteinases (MMPs). However, the molecular mechanism of MMP25 in head and neck cancer pathogenesis remains unclear. Methods: MMP25 expression was analyzed using The Cancer Genome Atlas (TCGA) database, and its influence on clinical prognosis was performed using Kaplan-Meier and Cox regression analyses. The correlation between MMP25 and immune infiltration was investigated by CIBERSORT, TIMER, and ESTIMATE. In addition, the relationship between MMP25 expression and molecular mechanisms was analyzed by gene set enrichment analysis (GSEA), gene ontology (GO), and weighted gene co-expression network analysis (WGCNA). Results: MMP25 expression level correlated with prognosis and immune infiltrating levels, especially activated CD4 + memory T cells, in head and neck cancer. Moreover, MMP25 expression potentially mediated genes, such as IRF8, IKZF1, and DOCK2, and tumor-associated pathways, including p53 signaling, PI3K/AKT/mTOR signaling, and JAK/STAT signaling pathway. Conclusions: These findings suggested that MMP25 plays a critical role in the prognosis and immune infiltration level of head and neck cancer. In addition, MMP25 expression significantly correlated with the regulation of various oncogenes and tumor-related pathways.

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Section: Discussionsupporting

confidence: 83%

MMP25 Regulates Immune Infiltration Level and Survival Outcome in Head and Neck Cancer Patients

Liang

Guan

et al. 2020

Front. Oncol.

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“…MMP2 and MMP9, members of the MMP family, have been reported to drive metastasis in various cancer types, including pancreatic, hepatocellular and lung cancers (49). The upregulation of MMP2 and MMP9 is associated with poor prognosis in patients with ovarian and breast cancers (50,51). Furthermore, it has been reported that MMP2 and MMP9 promote the migration and invasion of cancer cells via regulation of the ERK signaling pathway (52,53).…”

Section: Discussionmentioning

confidence: 99%

CXCL1 stimulates migration and invasion in ER‑negative breast cancer cells via activation of the ERK/MMP2/9 signaling axis

Yang

Chen

et al. 2019

Int J Oncol

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Chemokine (C-X-C motif) ligand 1 (CXCL1), a member of the CXC chemokine family, has been reported to be a critical factor in inflammatory diseases and tumor progression; however, its functions and molecular mechanisms in estrogen receptor α (ER)-negative breast cancer (BC) remain largely unknown. The present study demonstrated that CXCL1 was upregulated in ER-negative BC tissues and cell lines compared with ER-positive tissues and cell lines. Treatment with recombinant human CXCL1 protein promoted ER-negative BC cell migration and invasion in a dose-dependent manner, and stimulated the activation of phosphorylated (p)- extracellular signal-regulated kinase (ERK)1/2, but not p-STAT3 or p-AKT. Conversely, knockdown of CXCL1 in BC cells attenuated these effects. Additionally, CXCL1 increased the expression of matrix metalloproteinase (MMP)2/9 via the ERK1/2 pathway. Inhibition of MEK1/2 by its antagonist U0126 reversed the effects of CXCL1 on MMP2/9 expression. Furthermore, immunohistochemical analysis revealed a strong positive association between CXCL1 and p-ERK1/2 expression levels in BC tissues. In conclusion, the present study demonstrated that CXCL1 is highly expressed in ER-negative BC, and stimulates BC cell migration and invasion via the ERK/MMP2/9 pathway. Therefore, CXCL1 may serve as a potential therapeutic target in ER-negative BC.

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“…Matrix metalloproteinases (MMPs) serve as the proteolytic enzymes of ECM relying on zinc, which is commonly used by cells via migration. MMP-2 and MMP-9 have closely been linked to the invasion of various malignancies [22,23]. Hence, we investigated MMP-2 and MMP-9 translations to assess the contribution of miR-145-5p to EOC invasion.…”

Section: Mir-223 Prohibited Eoc Cell Migrationmentioning

confidence: 99%

MicroRNA-145-5p regulates the proliferation of epithelial ovarian cancer cells via targeting SMAD4

Zhou¹,

Zhang²,

Li³

et al. 2020

J Ovarian Res

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Background: Epithelial ovarian cancer (EOC) is one of the most prevalent malignancies affecting females worldwide; however, its etiology mechanism remains unclear. In various malignancies, miR-145-5p is a widely accepted and versatile miRNA. Therefore, our research focused on exploring the activity and etiology of miR-145-5p in the modulation of metastasis, migration, and proliferation of EOC cells. The direct reactions between the 3′UTRs of SMAD4 mRNA and miR-145-5p were verified using dual luciferase reporter test. SKOV-3 cells were subsequently transfected using miR-145-5p mimics. Cell migration, death, and proliferation were evaluated using MTT, flow cytometry, and Transwell test. In addition, SMAD4 transcription and translation were evaluated using qRT-PCR and Western blot. Results: We found that miR-145-5p expression was repressed prevalently in EOC tissues, apart from SMAD4 upregulation. Excessive miR-145-5p expression remarkably reinforced EOC cell death and repressed EOC cell proliferation. Furthermore, upregulated miR-145-5p expression noticeably repressed migration via MMP-2 and MMP-9 downregulation. Moreover, SMAD4 was downregulated via miR-145-5p transfection. The dual luciferase test revealed that miR-145-5p directly targeted SMAD4. Conclusions: Our research suggests that miR-145-5p serves as a malignancy repressor and exerts an essential impact on inhibiting malignancy generation and reinforcing EOC death via targeting SMAD4. MiR-145-5p application could serve as a promising strategy to treat EOC.

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The prognostic values of matrix metalloproteinases in ovarian cancer

Cited by 30 publications

References 30 publications

MMP25 Regulates Immune Infiltration Level and Survival Outcome in Head and Neck Cancer Patients

MMP25 Regulates Immune Infiltration Level and Survival Outcome in Head and Neck Cancer Patients

CXCL1 stimulates migration and invasion in ER‑negative breast cancer cells via activation of the ERK/MMP2/9 signaling axis

MicroRNA-145-5p regulates the proliferation of epithelial ovarian cancer cells via targeting SMAD4

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