The Prognostic Values of GDF-15 in Comparison with NT-proBNP in Patients with Normotensive Acute Pulmonary Embolism

Duran, Latif; Kayhan, Servet; Güzel, Aygül; Ince, Meltem; Katı, Celal; Akdemir, Hızır Ufuk; Yılmaz, Yücel; Zengin, Halit; Okuyucu, Ali; Murat, Naci

doi:10.7754/clin.lab.2013.130827

Cited by 13 publications

(19 citation statements)

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“…This is associated with increased risk of thromboembolic events [55]. Elevated GDF 15 in our studied splenectomized TI patients is similar to the findings of Musallam et al [13] and could reflect increased cardiovascular risk among them [56,57].…”

Section: Discussionsupporting

confidence: 85%

Growth differentiation factor-15 in children and adolescents with thalassemia intermedia: Relation to subclinical atherosclerosis and pulmonary vasculopathy

Tantawy

Adly

Ismail

et al. 2015

Blood Cells, Molecules, and Diseases

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Section: Discussionsupporting

confidence: 85%

Growth differentiation factor-15 in children and adolescents with thalassemia intermedia: Relation to subclinical atherosclerosis and pulmonary vasculopathy

Tantawy

Adly

Ismail

et al. 2015

Blood Cells, Molecules, and Diseases

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“…However, GDF-15 is non-tissue specific; secretion of GDF-15 is produced by a wide variety of cells4 and is seen in high concentrations in various diseases 5. It may therefore not be surprising that GDF-15 has been identified as predictor for all-cause mortality in a wide spectrum of diseases: cardiovascular diseases,6 7 various types of cancers8 9 and pulmonary diseases 10 11. To that end, the use of GDF-15 in risk stratification has been doubted because of its lack of disease specificity 12.…”

Section: Introductionmentioning

confidence: 99%

Growth differentiation factor-15 as candidate predictor for mortality in adults with pulmonary hypertension

Geenen¹,

Baggen²,

Kauling³

et al. 2019

Heart

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ObjectiveDespite its predictive value for mortality in various diseases, the relevance of growth differentiation factor-15 (GDF-15) as prognostic biomarker in pulmonary hypertension (PH) remains unclear. This study investigated the association between GDF-15 and outcomes in adults with PH.MethodsThis is a single-centre prospective observational cohort study. All adults with PH were included at the day of their diagnostic right heart catheterisation between 2012 and 2016. PH due to left heart disease was excluded. Venous blood sampling was performed and included GDF-15 and N-terminal pro-B-type natriuretic peptide (NT-proBNP) measurements. Kaplan-Meier curves and Cox regression analysis were used to investigate the association between GDF-15 and a composite endpoint of death or lung transplantation. We adjusted for age and NT-proBNP in multivariable analysis. Reference values were established by GDF-15 measurements in healthy controls.ResultsGDF-15 was measured in 103 patients (median age 59.2 years, 65% women, 51% pulmonary arterial hypertension). GDF-15 was elevated in 76 patients (74%). After a median follow-up of 3.4 (IQR 2.3–4.6) years, 32 patients (31.1%) reached the primary endpoint. Event-free survival 2 years after diagnosis was 100% in patients with normal GDF-15 versus 72.4% in patients with elevated GDF-15 (p=0.007). A significant association was found between GDF-15 and the primary endpoint (HR per twofold higher value 1.77, 95% CI 1.39 to 2.27, p<0.001), also after adjustment for age and NT-proBNP (HR 1.41, 95% CI 1.02 to 1.94, p=0.038).ConclusionsHigh GDF-15 levels are associated with an increased risk of death or transplant in adults with PH, independent of age and NT-proBNP. As non-specific biomarker, GDF-15 could particularly be useful to detect low-risk patients.

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“…[ 33 34 35 ] Furthermore, GDF-15 is also a newly identified biomarker for risk stratification of PE. [ 36 37 ] However, it needs to be further investigated that whether GDF-15 can predict the thromboembolic risk in AE-COPD.…”

Section: P Athogenic M Echanisms and mentioning

confidence: 99%

Pulmonary Embolism in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Cao

Dong

Cao

2018

Chinese Medical Journal

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Objective:In most countries, nearly 6% of the adults are suffering from chronic obstructive pulmonary disease (COPD), which puts a huge economic burden on the society. Moreover, COPD has been considered as an independent risk factor for pulmonary embolism (PE). In this review, we summarized the existing evidence that demonstrates the associations between COPD exacerbation and PE from various aspects, including epidemiology, pathophysiological changes, risk factors, clinical features, management, and prognosis.Data Sources:We searched the terms “chronic obstructive pulmonary disease,” “pulmonary embolism,” “exacerbations,” and “thromboembolic” in PubMed database and collected the results up to April 2018. The language was limited to English.Study Selection:We thoroughly examined the titles and abstracts of all studies that met our search strategy. The data from prospective studies, meta-analyses, retrospective studies, and recent reviews were selected for preparing this review.Results:The prevalence of PE in patients with COPD exacerbation varied a lot among different studies, mainly due to the variations in race, sample size, study design, research setting, and enrollment criteria. Overall, whites and African Americans showed significantly higher prevalence of PE than Asian people, and the hospitalized patients showed higher prevalence of PE compared to those who were evaluated in emergency department. PE is easily overlooked in patients with COPD exacerbation due to the similar clinical symptoms. However, several factors have been identified to contribute to the increased risk of PE during COPD exacerbation. Obesity and lower limb asymmetry were described as independent predictors for PE. Moreover, due to the high risk of PE, thromboprophylaxis has been used as an important treatment for hospitalized patients with COPD exacerbation.Conclusions:According to the previous studies, COPD patients with PE experienced an increased risk of death and prolonged length of hospital stay. Therefore, the thromboembolic risk in patients with acute exacerbation of COPD, especially in the hospitalized patients, should carefully be evaluated.

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The Prognostic Values of GDF-15 in Comparison with NT-proBNP in Patients with Normotensive Acute Pulmonary Embolism

Cited by 13 publications

References 0 publications

Growth differentiation factor-15 in children and adolescents with thalassemia intermedia: Relation to subclinical atherosclerosis and pulmonary vasculopathy

Growth differentiation factor-15 in children and adolescents with thalassemia intermedia: Relation to subclinical atherosclerosis and pulmonary vasculopathy

Growth differentiation factor-15 as candidate predictor for mortality in adults with pulmonary hypertension

Pulmonary Embolism in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

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