The prognostic values of estrogen receptor alpha and beta in patients with gastroesophageal cancer

Abstract

Background: Published studies have investigated the prognostic roles of estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) in gastroesophageal cancer patients with the controversial results. The aim of the study was to systematically evaluate the impacts of ERα and ERβ on the overall survival (OS) in patients. Method: Relevant eligible studies were extracted from PubMed, Embase, Web of Science, CNKI and Wanfang databases (from the start date to November 2018) following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. HR (hazard ratio) with 95% confidence intervals (CIs) were used to assess the prognostic values of ERα and ERβ for OS in patients. Results: High ERα expression was associated with poor OS (HR = 1.58, 95% CI = 1.29–1.94, P < .001) and ERβ with better OS (HR = 0.56, 95% CI = 0.37–0.83, P = .004) in gastroesophageal cancer. Furthermore, unfavorable OS was found in Chinese gastroesophageal patients with higher ERα expression (HR = 1.57, 95% CI = 1.25–1.96, P < .001) and better OS with higher ERβ expression (HR = 0.51, 95% CI = 0.31–0.83, P < .01) in our subgroup analysis. Meanwhile, worse OS was found in esophageal squamous cell carcinoma (ESCC) patients with high ERα expression (HR = 1.74, 95% CI = 1.33–2.26, P < .001), and favorable OS in ESCC with ERβ overexpression (HR = 0.40, 95% CI = 0.31–0.52, P < .001). Besides, high ERα expression was associated with lower tumor differentiation in ESCC (OR = 1.64; 95% CI = 1.02–2.64, P = .04) and ERβ was linked with better tumor differentiation in gastric adenocarcinoma (GCA) (OR = 0.49; 95% CI = 0.26–0.94, P = .03). Conclusions: ERα and ERβ might serve as potential prognostic biomarkers for gastroesophageal cancer patients. ERα overexpression predicted poor OS and lower tumor differentiation, and ERβ suggested favorable OS and better tumor differentiation. Further related studies should be performed to test these results.

Interaction of Estradiol and Endoplasmic Reticulum Stress in the Development of Esophageal Carcinoma

“…Thus, studying the functions and mechanisms of steroids and steroid antagonists holds great promise for esophageal cancer treatment and prevention. With the latest research, it has been found that overexpressions of estrogen receptor α and β in esophageal malignant tumors are associated with prognosis ( 6 , 13 ). In vitro studies also demonstrated that estrogens have remarkable inhibitory effect on the occurrence of esophageal cancer ( 14 , 15 ).…”

Câncer Gástrico Com Expressão Positiva Do Receptor De Estrogênio Alfa: Uma Série De Casos De Um Único Centro Ocidental

“…Thus, we do not know whether the expression of ER has differences in patients undergoing palliative treatment. Still, variations in results compared with other studies are predicted due to different evaluation criteria for IHC results and antibody clones used 8 , 23 , 28 . Still, the analysis only considered ERa, the subtype which is more associated with GC prognosis in literature 9 , 28 .…”

“…In contrast, the ERß positivity could have a protective effect against the invasiveness 25 . Another meta-analysis that included 11 studies also revealed an association between the expression of ERa with undifferentiated histology and worse OS; on the contrary, the expression of ERß was related to well-differentiated tumors and better survival 28 .…”

Sex-dependent development of Kras-induced anal squamous cell carcinoma in mice

“…Estrogen dependence of anal SCC formation. Estrogen has a known role in the development of several tumors [27][28][29][30][31][32] and a correlation with Kras-mutant cancer [29][30][31][32]. Thus, we tested whether the anal SCC tumor development in a papillomavirus-negative context was driven by estrogen.…”