The prognostic value of tumour-infiltrating lymphocytes in pancreatic cancer: a systematic review and meta-analysis

Orhan, Adile; Vogelsang, Rasmus Peuliche; Andersen, Malene Broholm; Madsen, Michael Tvilling; Hølmich, Emma Rosenkrantz; Raskov, Hans; Gögenür, Ismail

doi:10.1016/j.ejca.2020.03.013

Cited by 113 publications

(69 citation statements)

References 60 publications

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“…Tumor infiltrating lymphocytes (TIL) can be viewed as a surrogate marker of the anti-tumor immune response and, histologically, tumors can be seen to be “immune hot” (containing large numbers of TIL) and “immune cold” (containing few TIL) [ 16 ]. A number of studies, using both visual assessment and digital image analysis (DIA), have demonstrated that TIL are highly prognostic markers associated with better patient survival in various malignancies including lung, breast, melanoma, pancreas and CRC [ 17 , 18 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Immuno-Interface Score to Predict Outcome in Colorectal Cancer Independent of Microsatellite Instability Status

Nestarenkaite

Fadhil

Rasmusson

et al. 2020

Cancers

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Tumor-associated immune cells have been shown to predict patient outcome in colorectal (CRC) and other cancers. Spatial digital image analysis-based cell quantification increases the informative power delivered by tumor microenvironment features and leads to new prognostic scoring systems. In this study we evaluated the intratumoral density of immunohistochemically stained CD8, CD20 and CD68 cells in 87 cases of CRC (48 were microsatellite stable, MSS, and 39 had microsatellite instability, MSI) in both the intratumoral tumor tissue and within the tumor-stroma interface zone (IZ) which was extracted by a previously developed unbiased hexagonal grid analytics method. Indicators of immune-cell gradients across the extracted IZ were computed and explored along with absolute cell densities, clinicopathological and molecular data, including gene mutation (BRAF, KRAS, PIK3CA) and MSI status. Multiple regression modeling identified (p < 0.0001) three independent prognostic factors: CD8+ and CD20+ Immunogradient indicators, that reflect cell migration towards the tumor, were associated with improved patient survival, while the infiltrative tumor growth pattern was linked to worse patient outcome. These features were combined into CD8-CD20 Immunogradient and immuno-interface scores which outperformed both tumor-node-metastasis (TNM) staging and molecular characteristics, and importantly, revealed high prognostic value both in MSS and MSI CRCs.

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Section: Introductionmentioning

confidence: 99%

Immuno-Interface Score to Predict Outcome in Colorectal Cancer Independent of Microsatellite Instability Status

Nestarenkaite

Fadhil

Rasmusson

et al. 2020

Cancers

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“…TME (Gentles et al, 2015;Orhan et al, 2020). As there is no gold standard for inferring immune infiltrate from the RNA-seq profile, we chose ssGSEA-based ImmuCellAI and deconvolution-based quanTIseq algorithms in inferring the composition of TIICs.…”

Section: Discussionmentioning

confidence: 99%

T-Box Transcription Factor 22 Is an Immune Microenvironment-Related Biomarker Associated With the BRAFV600E Mutation in Papillary Thyroid Carcinoma

Dong

Song

et al. 2020

Front. Cell Dev. Biol.

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Papillary thyroid cancer (PTC) is the most common malignant disease in endocrine systems. T-box transcription factor 22 (TBX22) is a phylogenetically conserved family member that has not been widely characterized in cancers. In this study, we explored the potential clinical significance and biological functions of TBX22 in PTC. Comprehensive analyses of TBX22 were based on the public databases and our local qRT-PCR cohort. We observed that TBX22 was significantly downregulated in PTC compared with normal tissues. TBX22 was associated with several clinicopathological factors in PTC. Low TBX22 expression correlated with BRAFV600E and TERT mutation. Functional enrichment analysis revealed that cancer-related pathways and immune progress were closely associated with TBX22 in PTC. In TBX22-low PTC, high immune infiltration levels with increased CD8+ T cells, natural killer, M1 macrophages, and T-regulatory cells were observed. TBX22 was negatively correlated with the activity of different steps of the anticancer immunity cycle. Functionally, overexpression of TBX22 inhibited the proliferation, invasion, and migration in PTC cells, while knocking down of TBX22 showed the opposite effects. The present findings disclose that TBX22, as an immune microenvironment-related biomarker, could be an important tumor suppresser gene and might inform the management of PTC patients better.

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“…For example, in breast cancer, only sTILs provide valuable information [57]. Apart from TILs, other complementary biomarkers such as the CD4, CD8 and forkhead box P3 are of great relevance in the assessment of TILs function [63,64].…”

Section: Tumour-infiltrating Lymphocytes (Tils)mentioning

confidence: 99%

Biomarkers for precision immunotherapy in the metastatic setting: hope or reality?

Sajjadi¹,

Venetis²,

Scatena³

et al. 2020

ecancer

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Precision immunotherapy is a crucial approach to improve the efficacy of anti-cancer treatments, particularly in the metastatic setting. In this respect, accurate patient selection takes advantage of the multidimensional integration of patients' clinical information and tumourspecific biomarkers status. Among these biomarkers, programmed death-ligand 1, tumourinfiltrating lymphocytes, microsatellite instability, mismatch repair and tumour mutational burden have been widely investigated. However, novel tumour-specific biomarkers and testing methods will further improve patients' outcomes. Here, we discuss the currently available strategies for the implementation of a precision immunotherapy approach in the clinical management of metastatic solid tumours and highlight future perspectives.

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The prognostic value of tumour-infiltrating lymphocytes in pancreatic cancer: a systematic review and meta-analysis

Cited by 113 publications

References 60 publications

Immuno-Interface Score to Predict Outcome in Colorectal Cancer Independent of Microsatellite Instability Status

Immuno-Interface Score to Predict Outcome in Colorectal Cancer Independent of Microsatellite Instability Status

T-Box Transcription Factor 22 Is an Immune Microenvironment-Related Biomarker Associated With the BRAFV600E Mutation in Papillary Thyroid Carcinoma

Biomarkers for precision immunotherapy in the metastatic setting: hope or reality?

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