The prognostic value of the preoperative albumin to alkaline phosphatase ratio in patients with non‐small cell lung cancer after surgery

Abstract

Background To assess the potential prognostic value of the albumin to alkaline phosphatase ratio (AAPR) in patients with non‐small cell lung cancer (NSCLC) after surgery. Methods The log‐rank and Kaplan‐Meier analyses were performed to detect differences in survival levels between different groups. A model of Cox proportional hazards was used to perform univariate and multivariate survival analyses. Comparisons of receiver operating characteristic (ROC) curves and the likelihood ratio test (LRT) were also utilized to compare the prognostic abilities of different systems for overall survival (OS) prediction. Results The optimal cut‐off value of the preoperative AAPR was 0.64. A decreased AAPR was associated with several clinicopathological and clinicolaboratory variables related to cancer progression. The preoperative AAPR of patients was positively correlated with the poor prognosis of NSCLC. In multivariate analyses, the preoperative AAPR was identified as an independent prognostic factor for disease‐free survival (DFS; P = 0.001) and overall survival (OS; P = 0.003). The LRT showed that the AAPR tumor‐node‐metastasis (TNM) system presented a significantly larger χ2 value (112.4 vs. 89.2, respectively, P < 0.01) and a relatively smaller Akaike information criterion (AIC) value (2955 vs. 2977, respectively, P < 0.01) than the TNM staging system. Conclusion Preoperative AAPR was a potentially valuable prognostic factor in NSCLC patients who underwent surgery. Our results further showed that the AAPR‐TNM system was superior to the current TNM staging system.

<p>Prognostic Value of the Combination of CEA and Fibrinogen/Albumin Ratio in Resectable Gastric Cancer</p>

“…Malnutrition can lead to the decline of immune function in cancer patients, thus increasing the risk of postoperative complications and tumor progression. 21 Previous studies have reported that hypoalbuminemia is associated with disease progression and poor prognosis in patients with colon cancer, 22 pancreatic cancer, 23 non-small cell lung cancer, 24 ovarian cancer, 25 and GC. 26 Furthermore, this study shows that preoperative CEA is an independent prognostic factor of survival, consistent with previous studies.…”

Prognostic Significance of Pretreatment Albumin to Alkaline Phosphatase Ratio in Human Cancers: A Meta-Analysis

“…The characteristics of the included studies were shown in Table 1. In the current research, 15 retrospective articles with 6,062 cancer patients were included [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29]. Because of the subgroup analysis in three articles [15,17,19], we regarded them as 2 or 3 independent studies.…”

Prognostic Value of Preoperative Albumin-to-Alkaline Phosphatase Ratio in Patients with Muscle-Invasive Bladder Cancer After Radical Cystectomy

“…[5][6][7][8][9] The albumin-to-alkaline phosphatase ratio (AAPR), a novel blood biomarker, has been shown to be associated with the prognosis of liver cancer, nasopharyngeal cancer, small cell lung cancer, kidney cancer and other tumors. [10][11][12][13] However, data on the relationship between AAPR and bladder tumors are rare. The aim of this study was to investigate the relationship between preoperative AAPR and the overall survival of patients undergoing radical cystectomy of MIBC.…”