The prognostic value of the advanced lung cancer inflammation index (ALI) for patients with neuroblastoma

Abstract

Objective The advanced lung cancer inflammation index (ALI) can predict the survival of patients with lung cancer and other malignancies. However, the prognostic significance of ALI in neuroblastoma has not been reported. This study aimed to evaluate the correlation between ALI and neuroblastoma patient prognosis. Methods We retrospectively analyzed the data of 72 neuroblastoma patients treated between January 2014 and August 2020. ALI calculation: Body mass index (BMI) × serum albumin (ALB)/neutrophil-to-lymphocyte ratio (NLR). The optimal cutoff points of prognostic biomarkers were determined by generating receiver operating characteristic (ROC) curves. According to the cutoff value, the patients were categorized into low or high ALI groups. The chi-square test was used to compare clinical parameters between the two groups. Potential prognostic factors associated with overall survival (OS) were assessed using Kaplan–Meier and Cox regression analyses. Results The optimal cutoff value of ALI was 49.17. The low ALI group showed more severe clinical characteristics and poorer survival rates. Univariate and multivariate Cox analyses suggested that ALI and the International Neuroblastoma Staging System (INSS) stage were independent prognostic factors for neuroblastoma patients. Conclusions Low ALI is associated with poor prognosis in neuroblastoma patients. ALI may be an independent prognostic biomarker for neuroblastoma.

Effect of Chemotherapy on hs- C Reactive Protein, Some Blood Picture and Kidney Function in Patients With Neuroblastoma

“…The same table (5) and figure (6) show a significant increase in the level of platelet (PLT) in B group in comparison with A and C groups (p≤0.05). It was found a significant increase in the level of Platelets (PLT) in C group in comparison with A group (p≤0.05).…”

“…The amount of the infection in the human body increases with its levels [5]. Despite the fact that this illness has been treated with cutting-edge medications such as surgery, chemotherapy, radiation, myeloablative consolidation treatment with stem cell rescue or transplantation, and immunotherapy, many patients still have poor prognoses [6]. Endogenous metabolic waste products as well as medications and toxins are eliminated by the kidneys.…”

Prognostic value of the advanced lung cancer inflammation index in patients with gastric cancer after radical gastrectomy: a propensity-score matching cohort study and meta-analysis

“…As a novel and simple serum biomarker, the ALI has been widely investigated to be a potential prognostic biomarker in multiple malignancies except for lung cancer [ 28 ], such as colorectal cancer [ 14 ], endometrial cancer [ 29 ] and neuroblastoma [ 30 ]. Nevertheless, few studies [ 24 – 27 ] are available on the prognostic value of ALI in gastric cancer.…”

The Utility of Pre-Treatment Inflammation Markers as Associative Factors to the Adverse Outcomes of Vulvar Cancer: A Study on Staging, Nodal Involvement, and Metastasis Models

“…Lower pre-operative BAN score became one of two significant associative factors of advanced stage disease (adjusted odd ratio, aOR, 9.20, p = 0.001). The BAN score has been proposed as a novel indicator for assessing the nutritional status and ongoing systemic inflammation response in various advanced malignancies, including oesophagal [37] and gastric cancer [62,63]. It is hypothesised that patients with low BAN scores are more prone to be malnourished, leading to worse oncological outcomes [64].…”