The prognostic value of the neutrophil-to-lymphocyte ratio in patients with muscle-invasive bladder cancer treated with neoadjuvant chemotherapy and radical cystectomy

Black, Anna J; Zargar, Homayoun; Zargar‐Shoshtari, Kamran; Fairey, Adrian; Mertens, Laura S.; Dinney, Colin P.; Mir, Maria Carmen; Krabbe, Laura Maria; Cookson, Michael S.; Jacobsen, Niels; Griffin, Joshua; Montgomery, Jeffrey S.; Vasdev, Nikhil; Yu, Evan Y.; Xylinas, Évanguelos; Campain, Nicholas; Kassouf, Wassim; Dall′Era, Marc; Seah, Jo-An; Ercole, Cesar E.; Horenblas, Simon; McGrath, John; Aning, Jonathan; Shariat, Shahrokh F.; Wright, Jonathan L.; Thorpe, Andrew; Morgan, Todd M.; Holzbeierlein, Jeff M.; Bivalacqua, Trinity J.; North, Scott; Barocas, Daniel A.; Lotan, Yair; Grivas, Petros; Stephenson, Andrew J.; Shah, Jay B.; Rhijn, Bas W. van; Spiess, Philippe E.; Daneshmand, Siamak; Sridhar, Srikala S.; Black, Peter C.

doi:10.1016/j.urolonc.2019.09.023

Cited by 35 publications

(28 citation statements)

References 26 publications

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“…Studies in patients with muscle-invasive bladder cancer receiving neoadjuvant chemotherapy have shown that a higher baseline lymphocyte count or a lower NLR is associated with a better chemotherapy response as well as longer disease-free survival and OS [23][24][25]. Black et al [23] identified NLR >3 to be associated with a decreased response to neoadjuvant chemotherapy and shorter disease-specific survival and OS in nonmetastatic muscle-invasive bladder cancer. However, NLR had not been found to be prognostic in previous models, but it was recently associated with an ICI response in patients with aUC [17].…”

Section: Discussionmentioning

confidence: 99%

A New Prognostic Model in Patients with Advanced Urothelial Carcinoma Treated with First-line Immune Checkpoint Inhibitors

Khaki

Diamantopoulos

et al. 2021

European Urology Oncology

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Section: Discussionmentioning

confidence: 99%

A New Prognostic Model in Patients with Advanced Urothelial Carcinoma Treated with First-line Immune Checkpoint Inhibitors

Khaki

Diamantopoulos

et al. 2021

European Urology Oncology

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“…Furthermore, Leibowitz-Amit [20] found that MIBC patients with a high lymphocyte absolute value before neoadjuvant chemotherapy (NAC) were associated with a high complete response rate, while the complete response rate in patients with a high NLR and PLR was low. Black et al [21] also found that high NLR was associated with a decreased response to NAC and shorter prognosis in MIBC patients, which suggests that the inflammatory response affects the body's sensitivity to chemotherapy and the antiinflammatory treatment before chemotherapy may play an auxiliary role.…”

Section: Discussionmentioning

confidence: 98%

The prognostic value of routine preoperative blood parameters in muscle-invasive bladder cancer

Zhang

Ding

Wang

et al. 2020

Preprint

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Background A routine blood examination is one of the most rapid, convenient and inexpensive clinical examinations that can reflect a patient’s inflammatory status and other blood conditions, and the prognostic value of routine preoperative blood parameters in MIBC patients is still unclear, so we evaluated the prognostic value of routine preoperative blood parameters in muscle-invasive bladder cancer (MIBC) following radical cystectomy (RC). Methods Data on 202 patients with MIBC who underwent RC at our institution were retrospectively collected between October 2007 and August 2018. The median preoperative neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and hemoglobin (HGB) values were used as cutoffs to form the low and high NLR, low and high PLR, and low and high HGB groups, respectively. The clinicopathologic characteristics of each group were compared by chi-square and t tests. Kaplan-Meier survival and multivariate Cox regression analyses were used to analyze prognosis. Results The median NLR, PLR and HGB values were 2.42, 112 and 125g/L, respectively. Kaplan-Meier results showed that the low HGB group had poor progression-free survival (PFS), cancer-specific survival (CSS) and overall survival (OS). A high NLR and high PLR groups correlated only with poor OS. Multivariate Cox analyses showed that pathological T3/4 stage, positive lymph node status and low HGB were independent risk factors for PFS, CSS and OS, and age was the only independent risk factor for OS. Conclusion Preoperative peripheral blood HGB is an independent risk factor for the prognosis of MIBC patients. These data suggest that HGB may be a useful prognostic marker for MIBC patients undergoing RC.

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“…Furthermore, Leibowitz-Amit [20] found that MIBC patients with a high lymphocyte absolute value before neoadjuvant chemotherapy (NAC) were associated with a high complete response rate, while the complete response rate in patients with a high NLR and PLR was low. Black et al [21] also found that high NLR was associated with a decreased response to NAC and shorter prognosis in MIBC patients, which suggests that the inflammatory response affects the body's sensitivity to chemotherapy and the anti-inflammatory treatment before chemotherapy may play an auxiliary role. The prognosis of cancer patients is dependent not only on the biological characteristics of tumors, to a greater extent, but also on host reactions [5,6].…”

Section: Discussionmentioning

confidence: 98%

The prognostic value of routine preoperative blood parameters in muscle-invasive bladder cancer

et al. 2020

View full text Add to dashboard Cite

Background:A routine blood examination is one of the most rapid, convenient and inexpensive clinical examinations that can reflect a patient's inflammatory status and other blood conditions, and the prognostic value of routine preoperative blood parameters in MIBC patients is still unclear, so we evaluated the prognostic value of routine preoperative blood parameters in muscle-invasive bladder cancer (MIBC) following radical cystectomy (RC).Methods: Data on 202 patients with MIBC who underwent RC at our institution were retrospectively collected between October 2007 and August 2018. The median preoperative neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and hemoglobin (HGB) values were used as cutoffs to form the low and high NLR, low and high PLR, and low and high HGB groups, respectively. The clinicopathologic characteristics of each group were compared by chi-square and t tests. Kaplan-Meier survival and multivariate Cox regression analyses were used to analyze prognosis.Results: The median NLR, PLR and HGB values were 2.42, 112 and 125 g/L, respectively. Kaplan-Meier results showed that the low HGB group had poor progression-free survival (PFS), cancer-specific survival (CSS) and overall survival (OS). A high NLR and high PLR groups correlated only with poor OS. Multivariate Cox analyses showed that pathological T3/4 stage, positive lymph node status and low HGB were independent risk factors for PFS, CSS and OS, and age was the only independent risk factor for OS. Conclusion: Preoperative peripheral blood HGB is an independent risk factor for the prognosis of MIBC patients. These data suggest that HGB may be a useful prognostic marker for MIBC patients undergoing RC.

show abstract

The prognostic value of the neutrophil-to-lymphocyte ratio in patients with muscle-invasive bladder cancer treated with neoadjuvant chemotherapy and radical cystectomy

Cited by 35 publications

References 26 publications

A New Prognostic Model in Patients with Advanced Urothelial Carcinoma Treated with First-line Immune Checkpoint Inhibitors

A New Prognostic Model in Patients with Advanced Urothelial Carcinoma Treated with First-line Immune Checkpoint Inhibitors

The prognostic value of routine preoperative blood parameters in muscle-invasive bladder cancer

The prognostic value of routine preoperative blood parameters in muscle-invasive bladder cancer

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