The prognostic value of serum albumin levels on admission in patients with acute ST-segment elevation myocardial infarction undergoing a primary percutaneous coronary intervention

Oduncu, Vecih; Erkol, Ayhan; Karabay, Can Yücel; Kurt, Mustafa; Akgün, Taylan; Bulut, Mustafa; Pala, Selçuk; Kırma, Cevat

doi:10.1097/mca.0b013e32835c46fd

Cited by 135 publications

(132 citation statements)

References 23 publications

(27 reference statements)

Supporting

Mentioning

121

Contrasting

Unclassified

Order By: Relevance

“…[20][21][22]27 It was shown that hypoalbuminemia on admission is a strong independent predictor for long-term mortality and development of advanced heart failure in patients with STEMI. 22 Hartopo et al 27 demonstrated that low SA concentration was associated with in-hospital worse outcomes in patients with ACS. In our recently published study, we have shown that SA level at admission is independently associated with development of contrast-induced acute kidney injury after percutaneous coronary intervention in patients with ACS.…”

Section: Discussionmentioning

confidence: 99%

“…16 It is well known that lower concentrations of SA can predict increased morbidity and mortality risks in a range of cardiovascular diseases including ACS. [17][18][19][20][21][22] The aim of this study was to assess whether SA concentrations were associated with extent and complexity of CAD as assessed by the SYNTAX score and in-hospital all-cause mortality in patients with ACS.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Usefulness of Serum Albumin Concentration to Predict High Coronary SYNTAX Score and In-Hospital Mortality in Patients With Acute Coronary Syndrome

Kurtul¹,

Murat²,

Yarlıoğlueş³

et al. 2015

Angiology

View full text Add to dashboard Cite

High SYNTAX score is a predictor of adverse cardiovascular events, including mortality, in acute coronary syndromes (ACSs). Decreased serum albumin (SA) concentration is associated with an increased risk of cardiovascular events. We aimed to investigate whether SA levels at admission are associated with high SYNTAX score and in-hospital mortality in patients with ACS. The study included 1303 patients with ACS who underwent coronary angiography (CA). The patients were divided into 2 groups as high SYNTAX score (!33) and lower SYNTAX score ( 32). Baseline SA levels were significantly lower in patients with high SYNTAX score than with lower SYNTAX score (3.46 + 0.42 mg/dL vs 3.97+0.37 mg/dL, respectively; P < .001). On multivariate logistic regression, SA (<3.65 mg/dL) was an independent predictor of high SYNTAX score (odds ratio 4.329, 95% confidence interval 2.028-8.264; P < .001) together with admission glucose, estimated glomerular filtration rate, and left ventricular ejection fraction. In Cox regression analyses, systolic blood pressure, high SYNTAX score, and SA (<3.65 mg/dL) were found as independent predictors of in-hospital all-cause mortality. In conclusion, SA concentration on admission is inversely associated with high SYNTAX score and in-hospital mortality in ACS.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Usefulness of Serum Albumin Concentration to Predict High Coronary SYNTAX Score and In-Hospital Mortality in Patients With Acute Coronary Syndrome

Kurtul¹,

Murat²,

Yarlıoğlueş³

et al. 2015

Angiology

View full text Add to dashboard Cite

show abstract

“…Indeed, a previous study showed a significant association between decreased serum albumin levels and elevation of several inflammatory markers in patients with acute MI. 31 These relationships suggest synergistic effects of the serum albumin and hs-CRP levels for predicting long-term clinical outcomes in patients with atherosclerotic diseases. Moreover, serum albumin has been shown to have antioxidant activity, 32 related to its ligand-binding capacity.…”

Section: Discrimination and Reclassification Of Serum Albumin And Hs-crpmentioning

confidence: 99%

Independent and Combined Effects of Serum Albumin and C-Reactive Protein on Long-Term Outcomes of Patients Undergoing Percutaneous Coronary Intervention

Wada

Dohi

Miyauchi

et al. 2017

Circ J

View full text Add to dashboard Cite

“…Hartopo et al (37) have demonstrate that low SA level is related to inhospital adverse outcomes in ACS. Oduncu et al (11) have shown that hypoalbuminemia on admission was a strong independent predictor of long-term mortality and development of advanced heart failure in patients with STEMI undergoing p-PCI. Polat et al (38) demonstrate that hypoalbuminemia on admission was a strong independent predictor of long-term mortality in patients with acute decompensated systolic heart failure.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, hypoalbuminemia may increase blood viscosity and disrupt endothelial function on account of increased concentrations of free lysophosphatidylcholine (9). Several studies have showed a relation between low SA levels and increased cardiovascular morbidity and mortality (10,11). The SA might also have important roles in the acute phase of CAD, such as acute STEMI.…”

Section: Abant Med J 2015;4(3):230-238 231mentioning

confidence: 99%

The Utility of the Serum Albumin Levels on Admission for Predicting Angiographic No Reflow After Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Myocardial Infarction

Acet¹,

Ertaş²,

Aydın³

et al. 2015

Turk J Bioch

View full text Add to dashboard Cite

Amaç: Düşük serum albümin (SA) düzeyleri artmış kardiyovasküler mortalite ile ilişkilidir. Bazal SA seviyelerinin primer perkütan koroner girişim (p-PKG) yapılan hastalarda akışsızlık fenomeni ile ilgili olup olmadığını araştırdık. Yöntem: Geriye dönük olarak p-PKG ile tedavi edilen ST yükselmeli myokard infarktüsü (STYMI)'lı 358 hasta alındı. Hasta takibi hastaneiçi dönemde yapıldı. Önceki çalışmalara uygun olarak, TIMI akım derecesi ≤2, TIMI akım derecesi >3 olanlarda ise MBG <2 olanlar akışsızlık fenomeni olarak değerlendirildi. Hastalar başvuru SA düzeylerine göre iki gruba ayrıldı. SA <3,5 g/dl olanlar hipoalbüminemik grup ve SA düzey > 3,5 g/dl yüksek albüminemik grup olarak değerlendirildi. Bulgular: PKG yapılan toplam 358 (yaş 62±14 yaş, % 72 erkek) hasta alındı. Başvuru SA düzeyleri akışsızlık fenomeni olan grupta normal akım olan gruba göre anlamlı bir şekilde daha düşüktü (p=0,021). Sonuç: Başvuru SA seviyeleri akut STYMI hastalarda p-PKG sonrası-akışsızlık fenomeninin gelişimini tahmin edebilir. Başvuru hipoalbüminemili hastalar kötü klinik ve anjiyografik sonuçları ile ilgilidir ve STYMI p-PKG ile tedavi edilen hastalarda hastane içi mortalite ve pulmoner ödem ve kardiyojenik şok gelişimi tahmin edilebilmektedir.Objective: Low serum albumin (SA) levels are associated with increased cardiovascular mortality. We investigated whether baseline SA levels are associated with no-reflow in patients undergoing primary percutaneous coronary intervention (p-PCI). Method: STEMI patients treated by p-PCI were included in the study. The patients were followed during in hospital period. We defined angiographic no-reflow phenomenon as a coronary TIMI flow grade ≤2 after vessel re-canalized or TIMI flow grade 3 together with a final MBG < 2, in the same manner as was adopted in previous studies. The patients were divided into two groups according to the SA levels on admission, that is hypoalbuminemia group was SA<3.5 g/dl and high albuminemia group SA level was >3.5 g/dl. Results: A total of 358 patients (aged 62+14 years; 72% men) who underwent p-PCI were enrolled in the study. Admission SA levels were significantly lower in the noreflow group than in the normal-reflow group (p=0.021) Conclusion: Admission SA levels may predict the development of no-reflow phenomenon after p-PCI in patients with acute STEMI. Hypoalbuminemia on admission is related to worse clinical and angiographic outcomes and predicts inhospital mortality and development of advanced pulmonary edema and cardiogenic shock (higher Killip class) in patients treated with p-PCI for STEMI.Anahtar Kelimeler: Serum albumin düzeyi, Akışsızlık fenomeni, Perkütan koroner girişim, Akut myokard infarktüsü.

show abstract

The prognostic value of serum albumin levels on admission in patients with acute ST-segment elevation myocardial infarction undergoing a primary percutaneous coronary intervention

Abstract: Hypoalbuminemia on admission is a strong independent predictor for long-term mortality and development of advanced HF in patients with STEMI undergoing p-PCI.

Cited by 135 publications

References 23 publications

Usefulness of Serum Albumin Concentration to Predict High Coronary SYNTAX Score and In-Hospital Mortality in Patients With Acute Coronary Syndrome

Usefulness of Serum Albumin Concentration to Predict High Coronary SYNTAX Score and In-Hospital Mortality in Patients With Acute Coronary Syndrome

Independent and Combined Effects of Serum Albumin and C-Reactive Protein on Long-Term Outcomes of Patients Undergoing Percutaneous Coronary Intervention

The Utility of the Serum Albumin Levels on Admission for Predicting Angiographic No Reflow After Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Myocardial Infarction

Contact Info

Product

Resources

About