The prognostic value of serum progesterone and quantitative β-human chorionic gonadotropin in early human pregnancy

Daily, Celine A.; Laurent, Sherry L.; Nunley, Wallace C.

doi:10.1016/s0002-9378(94)70038-9

Cited by 43 publications

(29 citation statements)

References 15 publications

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“…(sensitivity 94.9% & specificity 92.7%). This is comparable to studies done by Hahlin et al(1991) [15] , Daily et al (1994) [16] . Plante BJ et al(2008) also concluded that among single biomarkers, progesterone had the greatest diagnostic accuracy in predicting viability.…”

Section: Discussionsupporting

confidence: 90%

Role of single serum progesterone assay in threatened abortion as a predictor of viable pregnancy

2016

AIMDR

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Background: Low progesterone levels have been linked to increased risk of miscarriage in first trimester of pregnancy. Methods: The observational, cross-sectional study was conducted over 100 pregnant females in first trimester of pregnancy < 12 weeks. All patients were subjected to sonography to confirm pregnancy & serum progesterone level testing immediately after admission and before initiation of treatment. Result: After analysis of the results, cut off value of serum progesterone as determined in this study came out to be 9.9 ng/ml with 94.9% sensitivity & 92.7% specificity. Conclusion: The value of serum progesterone estimation was of great help in differentiating between viable and non-viable pregnancy.

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Section: Discussionsupporting

confidence: 90%

Role of single serum progesterone assay in threatened abortion as a predictor of viable pregnancy

2016

AIMDR

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“…Although, Lijun & colleagues concluded that serum progesterone combined with β-hCG measurements, with a diagnostic accuracy of 85.7%, had the best prognostic reliability for predicting the outcome of threatened miscarriage compared to serum progesterone alone or β-hCG alone (Duan et al 2011), Daily and colleagues found that the mean serum progesterone was significantly high for viable pregnancies (22.1 ng/ml) compared to non-viable pregnancies (10.1 ng/ml) and they concluded that a serum progesterone assay alone is predictive of pregnancy outcome specially during the first 8 weeks of gestation (Daily et al 1994), also, Zainab Al Jufairi, found that serum progesterone level was significantly high in patients with viable pregnancies (20.48 ± 6.066 ng/ml) compared with patient with non-viable pregnancies ended by spontaneous abortion (7.78 ± 2.06 ng/ml) and she concluded that the serum progesterone alone is a reliable marker for prediction of early pregnancy failure (Zainab Ali Abdulla Al 2000).…”

Section: Discussionmentioning

confidence: 99%

Relation between single serum progesterone assay and viability of the first trimester pregnancy

Abdelazim¹,

Belal²,

Makhlouf³

2013

J Turkish German Gynecol Assoc

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This study was designed to detect the relation between serum progesterone and viability of pregnancy during the first trimester. Prospective study carried out in Al-Rashid Maternity and Ahmadi Kuwait oil company hospitals, over three years from February 2009 to February 2012. Two hundred and Sixty (260) pregnant women were hospitalized due to vaginal bleeding and/or abdominal pain during the first trimester of their pregnancies and were included in this study. Women included in this study were; sure of dates, conceived spontaneously with no history of infertility and had a positive serum pregnancy test. 2 ml blood samples were taken for women included in this study for serum progesterone assay. Women included in this study were followed by ultrasound for the viability of the pregnancy till the end of first trimester and the outcome of their pregnancy were recorded, while women with exogenous progesterone support or multiple pregnancies or suspected ectopic pregnancy or Hydatiform mole were excluded from this study. Data were collected and statistically analyzed to detect the relationship between serum progesterone level and viability of pregnancy during the first trimester. The mean age of the studied population was 32.7 ± 5.1 years, the mean gestational age at progesterone assay was 9.7 ± 0.5 week and by the end of the first trimester, women included in this study were classified according to the viability of their pregnancies into; viable pregnancy group 178 (68.5%) cases and non-viable pregnancy group (ended by miscarriage) 82 (31.5%) cases. The mean serum progesterone of the studied population was significantly high in viable pregnancy group (46.5 ± 7.4 ng/ml) compared to non-viable pregnancy group (9.9 ± 4.8 ng/ml), (p <0.05). In this study; 6.7% of viable pregnancies had serum progesterone level <10 ng/ ml, while 20.7% of non-viable pregnancies had serum progesterone level >10 ng/ml, the serum progesterone at cut off level 10 ng/ml was 79.3% sensitive to diagnose non-viable pregnancy and was 93.3% specific to diagnose viable pregnancy. Also, in this study; 1.1% of viable pregnancies had serum progesterone level <20 ng/ ml, while 4.8% of non-viable pregnancies had serum progesterone level >20 ng/ml, the serum progesterone at cut off level 20 ng/ml was 95.1% sensitive to diagnose non-viable pregnancy and was 98.9% specific to diagnose viable pregnancy. Serum progesterone is a reliable marker for early pregnancy failure and single assay of its serum level can differentiate between viable and non-viable pregnancies.

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“…Institutional review board approval was not obtained because of the retrospective noninterventional nature of this work. Two hundred eighty-one pregnancies (study group) fulfilled the following inclusion criteria: [1] an initial ␤hCG Յ150 mIU/mL on day 13 after embryo transfer (ET); [2] a singleton pregnancy, [3] the data on pregnancy outcome was available. We used 150 IU as a cutoff of ␤hCG level on day 13 from ET based on previous reports (4,6,8,10,11).…”

Section: Materials and Methods Study Groupmentioning

confidence: 99%

“…We used 150 IU as a cutoff of ␤hCG level on day 13 from ET based on previous reports (4,6,8,10,11). Randomly selected patients with initial ␤hCG Ͼ150 mIU/ mL, treated at the same time period who fulfilled criteria [2] and [3] comprised the control group (252 pregnancies). The selection of the subjects to the control group was done in the following randomized fashion.…”

Section: Materials and Methods Study Groupmentioning

confidence: 99%

“…Human chorionic gonadotropin level dynamically increases during early gestatation. Low levels of serum hCG in early pregnancy have been reported as a predictor of poor pregnancy outcome such as chemical and ectopic pregnancies as well as spontaneous miscarriage (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). However, the contribution of patients' characteristics and IVF treatment variables to low serum hCG level in early pregnancy has not been investigated.…”

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confidence: 99%

See 1 more Smart Citation

Early serum β-human chorionic gonadotropin in pregnancies after in vitro fertilization: contribution of treatment variables and prediction of long-term pregnancy outcome

Porat

Savchev

Bdolah

et al. 2007

Fertility and Sterility

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The prognostic value of serum progesterone and quantitative β-human chorionic gonadotropin in early human pregnancy

Cited by 43 publications

References 15 publications

Role of single serum progesterone assay in threatened abortion as a predictor of viable pregnancy

Role of single serum progesterone assay in threatened abortion as a predictor of viable pregnancy

Relation between single serum progesterone assay and viability of the first trimester pregnancy

Early serum β-human chorionic gonadotropin in pregnancies after in vitro fertilization: contribution of treatment variables and prediction of long-term pregnancy outcome

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