The prognostic value of serum procalcitonin in acute obstructive pyelonephritis

Baboudjian, Michael; Gondran-Tellier, Bastien; Bisceglie, Mathieu Di; Abdallah, Rony; Michel, F.; Al-Balushi, Khalid; Akiki, Akram; Gaillet, S.; Delaporte, V.; Karsenty, G.; Lechevallier, É.; Guieu, Régis; Boissier, R.

doi:10.1007/s00345-020-03353-2

Cited by 8 publications

(12 citation statements)

References 18 publications

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“…Notably, these three variables are generally included in routine investigations. The present study included most of the factors that were identi ed to be signi cant in the relevant previous studies [1][2][3][4][5][6][7][8][9][10][20][21][22][23][24][25]. However, we excluded lactate and ABGA levels from the analysis as they were already included in the Sepsis-3 diagnostic criteria [19].…”

Section: Discussionmentioning

confidence: 99%

“…Although the primary endpoint of their study was sepsis, PCT and presepsin were identi ed as the most signi cant predictors of sepsis. In the study by Baboudjian et al [10], multiple logistic regression analyses were performed for 110 patients with OAPN-US, including 39 patients with septic shock. The results of their study also indicated that PCT, CRP, and DM were the major predictors of septic shock.…”

Section: Discussionmentioning

confidence: 99%

“…Notably, several variables have been identi ed as predictive factors for septic shock in OAPN-US in accordance with previous systemic in ammatory response syndrome-based diagnosis criteria, including thrombocytopenia, positive blood cultures, decreased serum albumin, increased procalcitonin (PCT), leukocytosis, diabetes mellitus (DM), elevated C-reactive protein (CRP), absence of hypertension (HTN), and decreased erythrocyte sedimentation rate (ESR) [2][3][4][5][6][7][8]. However, only two studies used the Sepsis-3 criteria and concluded that PCT, CRP, DM, and presepsin are predictive factors for septic shock in cases of OAPN-US [9,10]. Moreover, several studies have been reported in the relevant literature, but no con rmatory predictors have been reported to date.…”

Section: Introductionmentioning

confidence: 99%

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Machine learning-based prediction of septic shock in patients with obstructive pyelonephritis caused by ureteral stones

Min

Chung

et al. 2023

Preprint

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Obstructive acute pyelonephritis (OAPN) is a common condition that can rapidly become life-threatening. In particular, OAPN associated with ureteral stones (OAPN-US) should be treated by a diversion of the urinary tract. Notably, we focused on predicting septic shock, which can be highly fatal. Previous studies have suggested multiple variables for predicting septic shock, but most studies used the Sepsis-2 criteria, which were revised to the Sepsis-3 criteria in 2016. Furthermore, no studies have identified a confirmatory variable or proposed combination of multiple variables for the prediction of septic shock. This study aimed to determine the best combination of potential predictors of septic shock in patients with OAPN-US based on the Sepsis-3 criteria. Our approach was based on machine learning (ML) because previous studies have demonstrated high performance of ML and because it can easily identify the combined effects of multiple variables. We selected three variables from approximately 30 factors and compared five ML algorithms. Notably, the random forest algorithm demonstrated the best performance, with an area under the receiver operating curve of 0.9965 and accuracy of 0.9583. Among the selected factors, procalcitonin had the highest Gini importance score. To the best of our knowledge, this is the first study to use ML for the predication of septic shock. Excellent predictions were made after identifying the optimal combination of multiple predictors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Machine learning-based prediction of septic shock in patients with obstructive pyelonephritis caused by ureteral stones

Min

Chung

et al. 2023

Preprint

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“…seventy-eight patients had serum-procalcitonin values slightly above the clinical threshold. The reason for this marginal increase of serum-procalcitonin in spreading odontogenic infections could be due to the lesser degree of systemic manifestations observed in spreading odontogenic infections compared with infections arising from visceral organs of the body in which an exponential increase in the level of serumprocalcitonin was reported [6,12,15].…”

Section: Statisticsmentioning

confidence: 99%

The Usefulness of Serum Procalcitonin in Determining the Severity of Spreading Odontogenic Infections in Patients Seen at Ile-Ife, Nigeria

Taofeek,

Olawunmi,

Tewogbade

et al. 2023

Archives Oral Maxillofac Surg

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Background:The high morbidity, mortality and cost of treatment of spreading odontogenic infections makes it critical to find diagnostic tools that can facilitate prompt and accurate management decision-making. Materials and methods:This is a prospective cohort study of 63 patients being managed for spreading odontogenic infection at the Obafemi Awolowo University Teaching Hospitals Complex, Ile Ife, Nigeria. Serum procalcitonin levels were recorded at three time points: At presentation, day-four and day-eight after treatment has commenced. The severity of spreading odontogenic infections was determined using the criteria described by Flynn, et al. A Mann-Whitney U test was used to compare the serum procalcitonin at different time points. A Receiver Operating Characteristic (ROC) curve was plotted to determine the diagnostic accuracy. The sensitivity, specificity, negative predictive value, positive predictive value, positive likelihood ratio and negative likelihood ratio of serum-procalcitonin as a diagnostic tool for spreading odontogenic infections were calculated. Results:Serum procalcitonin levels at presentation ranged from 51.8 pg/ml to 484.3 pg/ml with a mean value of 169.9 ± 108.0 pg/ml and median (interquartile range) value of 129.3 (81.5) pg/ml. There was an increase in serum procalcitonin level with increased severity of odontogenic infections, the relationship was statistically significant (H = 40.665, df = 2, p = < 0.001). The diagnostic accuracy of serum procalcitonin was 0.60 (95% CI = 0.40-0.77 ; p = 0.33) at a cut-off point of 168.3 pg/ml. Serum procalcitonin had moderate sensitivity (53.3%) and specificity (75.0%), high negative predictive value (83.7%), low positive predictive value (40.0%), a 1.6 positive likelihood ratio and a 0.5 negative likelihood ratio. Conclusion:There was a significant increase in serum procalcitonin level with increased severity of odontogenic infections. Thus, serum procalcitonin could differentiate between low to moderate severe and high severe spreading odontogenic infections. It can be used as an adjunct to traditional clinical methods of determining severity of spreading odontogenic infections.

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“…Outcome of urologic patients in the ICU database IBM® MarketScan® 5 . The study confirmed a frequency of 5.5% of sepsis in URS patients.…”

Section: A Cicvarić Et Almentioning

confidence: 99%

Characteristics and Treatment Outcomes of Urologic Patients Admitted to the Intensive Care Unit, Osijek University Hospital Center

Cicvarić

2023

ACC

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Due to their special characteristics, urologic patients require customized postoperative care. Significant comorbidity that is more common in the elderly urologic population, infections, or intraoperative complications may be the reason for surgical Intensive Care Unit (ICU) admission, and increased mortality 1-3 .The type of surgery influences the frequency of ICU admissions. According to data from the study by Ha et al., the most common admissions of urologic patients to the ICU were recorded after radical cystectomy 4 . The ICU admission was recorded in 76% of patients who had postoperative delirium and 54.8% of patients who did not have delirium 4 . Admissions to the ICU are less frequent in patients undergoing less invasive surgical procedures. Within 30 days of 104,100 outpatient urethroscopies (URS), all re-admissions to the hospital in patients older than 18 years were recorded in the American commercial

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The prognostic value of serum procalcitonin in acute obstructive pyelonephritis

Cited by 8 publications

References 18 publications

Machine learning-based prediction of septic shock in patients with obstructive pyelonephritis caused by ureteral stones

Machine learning-based prediction of septic shock in patients with obstructive pyelonephritis caused by ureteral stones

The Usefulness of Serum Procalcitonin in Determining the Severity of Spreading Odontogenic Infections in Patients Seen at Ile-Ife, Nigeria

Characteristics and Treatment Outcomes of Urologic Patients Admitted to the Intensive Care Unit, Osijek University Hospital Center

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