The Prognostic Value of Serum Neuron Specific Enolase (NSE) and S100B Level in Patients of Acute Spinal Cord Injury

Du, Wei; Li, Huinan; Sun, Juan; Xia, Yingpeng; Zhu, Rusen; Zhang, Xueli; Tian, Rong

doi:10.12659/msm.907406

Cited by 29 publications

(31 citation statements)

References 21 publications

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“…Biomarkers after traumatic spinal cord injury are fairly well developed [ 2 , 12 ]. However, biomarkers for SCI after aortic surgery are not as well-established, although some exist, where rises in intrathecal lactate is an early sign of spinal cord ischemia [ 8 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

Protein Profiling in Serum and Cerebrospinal Fluid Following Complex Surgery on the Thoracic Aorta Identifies Biological Markers of Neurologic Injury

Lindblom

Shen

Axén

et al. 2018

J. of Cardiovasc. Trans. Res.

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Surgery on the arch or descending aorta is associated with significant risk of neurological complications. As a consequence of intubation and sedation, early neurologic injury may remain unnoticed. Biomarkers to aid in the initial diagnostics could prove of great value as immediate intervention is critical. Twenty-three patients operated in the thoracic aorta with significant risk of perioperative neurological injury were included. Cerebrospinal fluid (CSF) and serum were obtained preoperatively and in the first and second postoperative days and assessed with a panel of 92 neurological-related proteins. Three patients suffered spinal cord injury (SCI), eight delirium, and nine hallucinations. There were markers in both serum and CSF that differed between the affected and non-affected patients (SCI; IL6, GFAP, CSPG4, delirium; TR4, EZH2, hallucinations; NF1). The study identifies markers in serum and CSF that reflect the occurrence of neurologic insults following aortic surgery, which may aid in the care of these patients.Electronic supplementary materialThe online version of this article (10.1007/s12265-018-9835-8) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Protein Profiling in Serum and Cerebrospinal Fluid Following Complex Surgery on the Thoracic Aorta Identifies Biological Markers of Neurologic Injury

Lindblom

Shen

Axén

et al. 2018

J. of Cardiovasc. Trans. Res.

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“…This protein was assessed in 6 studies. 22,24,28-31 Elevated concentrations of S100b are thought to be the consequence of cellular death. Since different cell types express this calcium binding protein, systemic increase is of low specificity.…”

Section: Resultsmentioning

confidence: 99%

Biomarkers in Traumatic Spinal Cord Injury—Technical and Clinical Considerations: A Systematic Review

Leister

Haider

Mattiassich

et al. 2020

Neurorehabil Neural Repair

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Objective. To examine (1) if serological or cerebrospinal fluid (CSF) biomarkers can be used as diagnostic and/or prognostic tools in patients with spinal cord injury (SCI) and (2) if literature provides recommendations regarding timing and source of biomarker evaluation. Data Sources. A systematic literature search to identify studies reporting on diagnostic and prognostic blood and/or CSF biomarkers in SCI was conducted in PubMed/MEDLINE, CINAHL, Science Direct, The Cochrane Library, ISI Web of Science, and PEDro. Study Selection. Clinical trials, cohort, and pilot studies on patients with traumatic SCI investigating at least one blood or CSF biomarker were included. Following systematic screening, 19 articles were included in the final analysis. PRISMA guidelines were followed to conduct this review. Data Extraction. Independent extraction of articles was completed by 2 authors using predefined inclusion criteria and study quality indicators. Data Synthesis. Nineteen studies published between 2002 and April 2019 with 1596 patients were included in the systematic review. In 14 studies, blood biomarkers were measured, 4 studies investigated CSF biomarkers, and 1 study used both blood and CSF samples. Conclusions. Serum/CSF concentrations of several biomarkers (S100b, IL-6, GFAP, NSE, tau, TNF-α, IL-8, MCP-1, pNF-H, and IP-10) following SCI are highly time dependent and related to injury severity. Future studies need to validate these markers as true biomarkers and should control for secondary complications associated with SCI. A deeper understanding of secondary pathophysiological events after SCI and their effect on biomarker dynamics may improve their clinical significance as surrogate parameters in future clinical studies.

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“…NSE is a 78 kDa glycolytic enzyme involved in glucose metabolism and is mainly found in neuronal and neuroendocrine cells. The role of NSE in acute spinal cord injury (SCI) via various molecular mechanisms and pathways have been reported previously (24).…”

Section: Discussionmentioning

confidence: 97%

Simvastatin in an experimental spinal cord injury model: a histopathological and biochemical evidence based study

Tascioglu¹,

Karatay²,

Yavuz³

et al. 2020

BLL

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AIM: In this study we tried to determine the possible neuroprotective effects of simvastatin in a rat model of Spinal Cord Injury (SCI) with the help of biochemical and histopathological tests. METHODS: Rats were divided into 5 groups:1) SCI control, 2) Sham operated, 3) SCI with 10 mg/kg intraperitoneal simvastatin, 4) SCI with 10 mg/kg oral simvastatin, 5) SCI with 10 mg/kg subcutaneous simvastatin. After the treatment period, all rats were sacrifi ced; their blood and spinal cord samples were taken for biochemical and histopathological assessment. RESULTS: When the groups were compared in terms of oedema and infl ammation status, the scores of groups receiving simvastatin were better than the control and sham groups (p = 0.001 and p = 0.038 respectively). When the 3 treatment groups (oral, intraperitoneal and subcutaneous simvastatin groups) were compared with each other in terms of infl ammation, haemorrhage and oedema, there were no signifi cant differences between groups (p = 0.112, p = 0.797 and p = 0.188, respectively). NSE and S100B levels were signifi cantly lower in the treatment groups compared to the sham group (p = 0.039 and p = 0.004 respectively). CONCLUSION: According to our biochemical and histopathological fi ndings, simvastatin 10 mg/kg has a positive impact in the spinal cord injury model in rats, regardless of route of application (Tab. 1, Fig. 5, Ref.

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The Prognostic Value of Serum Neuron Specific Enolase (NSE) and S100B Level in Patients of Acute Spinal Cord Injury

Cited by 29 publications

References 21 publications

Protein Profiling in Serum and Cerebrospinal Fluid Following Complex Surgery on the Thoracic Aorta Identifies Biological Markers of Neurologic Injury

Protein Profiling in Serum and Cerebrospinal Fluid Following Complex Surgery on the Thoracic Aorta Identifies Biological Markers of Neurologic Injury

Biomarkers in Traumatic Spinal Cord Injury—Technical and Clinical Considerations: A Systematic Review

Simvastatin in an experimental spinal cord injury model: a histopathological and biochemical evidence based study

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