The prognostic value of serial EEG recordings following acute neonatal asphyxia in full-term infants

Prognostic Significance of Amplitude-Integrated EEG during the First 72 Hours after Birth in Severely Asphyxiated Neonates

“…In those who presented with severely abnormal aEEG patterns, spontaneous recovery within 12 h toward normal voltage traces occurred in approximately one third of infants. Our data are in line with previous studies on conventional EEG showing that normalization of abnormal background patterns is not uncommon during the first day of life and associated with normal neurologic outcomes (22)(23)(24). Future studies investigating neuroprotective strategies should take this rate of spontaneous recovery into account.…”

EEG background features that predict outcome in term neonates with hypoxic ischaemic encephalopathy: A structured review

“…For example, voltage levels used to define an abnormality such as low voltage often differ between studies. Although not the primary goal of this review and meta-analysis, we note that in the case of isoelectric or flat trace EEG, different voltage amplitude levels are used in different studies: <10 lV was used in van Lieshout et al, 1995;Pressler et al, 2001;Zeinstra et al, 2001;Murray et al, 2009; <5 lV in Watanabe et al, 1980;Finer et al, 1981Finer et al, , 1983Holmes et al, 1982;Pezzani et al, 1986;Selton and Andre, 1997;Ter Horst et al, 2004;Hellström-Westas et al, 2006;Mariani et al, 2008;Shankaran et al, 2011;Horn et al, 2013 and<3 lV in Aso et al, 1989. Other studies did not provide an exact definition of flat trace (Wertheim et al, 1994;Laroia et al, 1998).…”

Abnormal Interhemispheric Synchrony in Neonatal Hypoxic-Ischemic Encephalopathy: A Retrospective Pilot Study

“…The first group (mild HIE) comprised infants who survived without major disabilities according to the WHO disability staging (score 5-10) and the second group (severe HIE) comprised infants who either died in the neonatal period or who survived with severe neurological disabilities as classified by the WHO disability score (score 0-4) [7]. Briefly, the WHO disability score explores 5 items: neuromotor development, mental development, hearing and visual function, speech and language, and epileptic seizures.…”

“…Abnormal interhemispheric synchrony, frequently called asynchrony, has been described in many clinical compromises in brain function [4,5] and has also been reported in HIE [6,7]. However, the prognostic value of abnormal interhemispheric synchrony in HIE is little discussed and probably underestimated.…”