The prognostic value of CYP2C subfamily genes in hepatocellular carcinoma

Abstract

Cytochrome P2C (CYP2C) subfamily members (CYP2C8,CYP2C9,CYP2C18, and CYP2C19) are known to participate in clinical drug metabolism. However, the association between CYP2C subfamily members and hepatocellular carcinoma (HCC) remains unclear. This study investigated the prognostic value of CYP2C subfamily gene expression levels with HCC prognosis. Data of 360 HCC patients in The Cancer Genome Atlas database and 231 in the Gene Expression Omnibus database were analyzed. Kaplan–Meier analysis and a Cox regression model were used to ascertain overall survival and recurrence‐free survival, and to calculate median survival time using hazard ratios (HR) and 95% confidence intervals (CI). In TCGA database, low expression of CYP2C8,CYP2C9, and CYP2C19 in tumor tissue was associated with a short median survival time (all crude P = 0.001, adjusted P = 0.004, P = 0.047, and P = 0.020, respectively). In TCGA database, joint effects analysis of the combinations of CYP2C8 and CYP2C9,CYP2C8 and CYP2C19, and CYP2C9 and CYP2C19 revealed that high expression of two genes (group 4; group IV, group d) was associated with a reduced risk of death as compared to low expression (group 1, group I, and group a) (adjusted P = 0.005, P = 0.013, and P = 0.016, respectively). In TCGA database, joint effects analysis of CYP2C8,CYP2C9, and CYP2C19 showed that the risk of death from HCC was lower for groups C and D than for group A (adjusted P = 0.012 and P = 0.008, respectively). CYP2C8,CYP2C9, and CYP2C19 gene expression levels are potential prognostic markers of HCC following hepatectomy.

Role of epoxy-fatty acids and epoxide hydrolases in the pathology of neuro-inflammation

“…In this mini-review, the recent literature related to the role of epoxy-fatty acids (EpFA) in mediating and controlling neuroinflammatory responses is summarized. A recent review described the possible cellular mechanisms that EpFAs modulate to mediate these effects [1]; thus, we focus primarily on the practical therapeutic applications including how genetic changes in EpFA signaling affect neuroinflammatory disease and how to modulate EpFA signaling pharmacologically.…”

Identification of the DNA Replication Regulator MCM Complex Expression and Prognostic Significance in Hepatic Carcinoma

“…There are two important risk factors for HCC, including alcohol consumption [ 2 ] and hepatitis virus [ 3 ]. Although the development of new targeted drugs and multidrug combinations has improved the battlefield for HCC, only about 5-14 percent of patients with HCC have a five-year survival rate [ 4 , 5 ], with the development of bioinformatics and high-throughput sequencing technology, inhibitor of apoptosis protein (IAP) family members [ 6 ], kinesin family members [ 6 ], cytochrome P2C (CYP2C) subfamily members [ 7 ], CDK1, PBK, RRM2, and ASPM [ 8 ]. Recently, Han et al found through bioinformatics that SCAMP3 may be an important marker in the development of liver cancer [ 9 ].…”

The down-regulation of the CYP2C19 gene is associated with aggressive tumor potential and the poorer recurrence-free survival of hepatocellular carcinoma

“…We therefore focused on the CYP family in the present study. Although impaired activity and expression of CYP proteins and genes in HCC were reported [ 14 ], little is known about the prognostic impact of the CYP gene expression status for HCC [ 15 – 18 ]. The aim of this study was to clarify the association between the oncological behavior of HCC and expression of CYP genes and to identify a novel biomarker for the prognosis of HCC.…”