The prognostic value of red cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in radiotherapy for oropharyngeal cancer

Abstract

This article has been peer reviewed and published immediately upon acceptance.It is an open access article, which means that it can be downloaded, printed, and distributed freely, provided the work is properly cited.

Prognostic values of systemic inflammation and nutrition‐based prognostic indices in oropharyngeal carcinoma

“…Several studies, including a meta‐analysis, have reported the prognostic utility of the NLR, LMR, PLR, PNI, and HS‐mGPS in head and neck cancers 9–20,22–29 . Regarding previous reports on a systematic review and meta‐analysis, Yang et al 22 investigated a total of 25 studies and demonstrated that higher pretreatment NLR was associated with poorer prognosis.…”

“…Several studies, including a meta‐analysis, have reported the prognostic utility of the NLR, LMR, PLR, PNI, and HS‐mGPS in head and neck cancers. 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 Regarding previous reports on a systematic review and meta‐analysis, Yang et al 22 investigated a total of 25 studies and demonstrated that higher pretreatment NLR was associated with poorer prognosis. Takenaka et al 23 reviewed 19 studies of head and neck cancer and showed that an elevated pretreatment NLR had a predictive value of poorer OS and DSS.…”

“…Fanetti et al 26 reported that a high NLR (cutoff value, 3) was a negative prognostic factor in a cohort of 125 patients with locally advanced OPC treated with CRT. Staniewska et al 27 investigated the prognostic utility of red cell distribution width, NLR, and PLR using the receiver operating characteristic (ROC) method in patients with OPC receiving RT and showed that the NLR (cutoff value, 2.099) was an independent predictor of OS in their multivariate analysis. In this study, the NLR cutoff value (1.65) determined by the ROC optimized for OS was not associated with DFS, DSS, or OS in the univariate and multivariate analyses.…”

Effect of NLR, PLR, RDW and HRR in the Evaluation of the Prognosis of Children with Pneumonia: Case-Control Study

“…23 Benzer şekilde diğer çalışmalarda da orofarinks kanseri ve küçük hücreli dışı akciğer kanserlerinde NLR'nin sağkalım için bağımsız bir öngörücü olduğu bulunmuştur. 4,5 Çalışmamızda literatür ile uyumlu olarak pnömoninin şiddeti arttıkça NLR'de anlamlı bir yükselme olduğu, NLR yükseldikçe yoğun bakım yatış riskinin anlamlı şekilde arttığı görüldü. Fakat literatürden farklı olarak pnömoninin şiddeti arttıkça PLR değerinde anlamlı bir değişiklik olmadığı saptandı.…”

“…3 Özellikle küçük hücreli dışı akciğer kanserlerinin ve üst solunum yolu kanserlerinin prognozunu tahmin etmedeki başarısı yapılan çalışmalarda görülmüştür. 4,5 Platelet/lenfosit oranı [platelet/lymphocyte ratio (PLR)], pnömoni gibi bulaşıcı hastalıkların şiddetini belirleyebilir ve vücuttaki inflamatuar yanıtın ve vasküler trombozun derecesini yansıtabilir. 6 Eritrosit dağılım genişliği [red cell distribution width (RDW)], dolaşım sistemindeki eritrosit hacminin varyasyon katsayısıdır.…”