The prognostic value of preoperative fibrinogen-to-prealbumin ratio and a novel FFC score in patients with resectable gastric cancer

Tang, Shuli; Lin, Lin; Cheng, Jianan; Zhao, Juan; Xuan, Qijia; Shao, Jiayue; Zhou, Yang; Zhang, Yanqiao

doi:10.1186/s12885-020-06866-6

Cited by 24 publications

(26 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Combining two indicators of opposite changes, PFR is a valuable marker in systemic inflammatory diseases. It was reported that PFR was illustrated as the novel indicator for the diagnosis in acute pancreatitis and cancer prognosis (23,24). Our study confirmed our hypothesis that PFR was associated with TCNS, VPT and NCV.…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Prealbumin to fibrinogen ratio is closely associated with diabetic peripheral neuropathy

Zang

Shi

Zhao

et al. 2020

Endocrine Connections

View full text Add to dashboard Cite

The aim of our study was to explore the diagnostic value of prealbumin to fibrinogen ratio (PFR) for predicting prognosis with the optimal cut-off value in diabetic peripheral neuropathy (DPN) patients. A total of 568 type 2 diabetes mellitus (T2DM) patients were enrolled in this study. The values including Toronto clinical neuropathy score (TCNS), nerve conduction velocity (NCV), vibration perception threshold (VPT), blood cells count, biochemical parameters, fibrinogen and PFR were recorded. The patients were divided into tertiles based on admission PFR value. Firstly, clinical parameters were compared among the groups. Secondly, a logistic regression and ROC analysis were performed as the statistical model. The percentage of DPN, TCNS and VPT were significantly higher in the lowest PFR tertile than in the middle PFR tertile and the highest PFR tertile (P<0.01-0.001). NCV was significantly lower in lowest PFR tertile than in the middle PFR tertile and the highest PFR tertile (P<0.01-0.001). The Spearman correlation analysis showed that PFR was negatively correlated with TCNS and VPT(P<0.001), while PFR was positively correlated with median motor NCV(P<0.001), peroneal motor NCV(P<0.001), median sensory NCV (P<0.001), and peroneal sensory NCV (P<0.001). After adjusting these potentially related factors, PFR was independently related to DPN (P=0.007). The area under ROC curve was 0.627. This study finds the first evidence to suggest PFR may be the key component associated with DPN in T2DM, while PFR might underlie the pathophysiologic features of DPN.

show abstract

Section: Discussionsupporting

confidence: 90%

“…In addition, previous studies have confirmed that PALB values are also inversely related to CRP values in inflammation (20,21,22). PALB to FIB ratio (PFR) is a new inflammation marker, which is closely related to acute pancreatitis and cancer (23,24). Therefore, we speculate that PFR may also be associated with DPN in T2DM.…”

Section: Introductionmentioning

confidence: 58%

Prealbumin to fibrinogen ratio is closely associated with diabetic peripheral neuropathy

Zang

Shi

Zhao

et al. 2020

Endocrine Connections

View full text Add to dashboard Cite

show abstract

“…[33][34][35] Recently, another inflammation biomarker FAR was found to be associated with the prognosis of manycancers. 19,36,37 To our best knowledge, this was the first study to prove that FAR was of great significance in predicting the prognosis of ICC. Moreover, FAR would be a valuable biomarker for predicting the prognosis of ICC, because it can be easily obtained from peripheral blood examinations.…”

Section: Discussionmentioning

confidence: 77%

The prognostic value of sarcopenia combined with preoperative fibrinogen–albumin ratio in patients with intrahepatic cholangiocarcinoma after surgery: A multicenter, prospective study

Wang

et al. 2021

Cancer Medicine

View full text Add to dashboard Cite

show abstract

“…To date, the tumor-node-metastasis (TNM) staging system remains the gold standard for predicting prognosis and guiding GC treatment decisions ( 5 ). However, the high heterogeneity leads to different outcomes among patients with the same TNM stage and treatments ( 6 ). Therefore, it is imperative to investigate the in-depth molecular mechanisms involved in GC occurrence and development to identify novel prognostic biomarkers and potential therapeutic targets.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Characterization of RNA Processing Factors in Gastric Cancer Identifies a Prognostic Signature for Predicting Clinical Outcomes and Therapeutic Responses

et al. 2021

View full text Add to dashboard Cite

RNA processing converts primary transcript RNA into mature RNA. Altered RNA processing drives tumor initiation and maintenance, and may generate novel therapeutic opportunities. However, the role of RNA processing factors in gastric cancer (GC) has not been clearly elucidated. This study presents a comprehensive analysis exploring the clinical, molecular, immune, and drug response features underlying the RNA processing factors in GC. This study included 1079 GC cases from The Cancer Genome Atlas (TCGA, training set), our hospital cohort, and two other external validation sets (GSE15459, GSE62254). We developed an RNA processing-related prognostic signature using Cox regression with the least absolute shrinkage and selection operator (LASSO) penalty. The prognostic value of the signature was evaluated using a multiple-method approach. The genetic variants, pathway activation, immune heterogeneity, drug response, and splicing features associated with the risk signature were explored using bioinformatics methods. Among the tested 819 RNA processing genes, we identified five distinct RNA processing patterns with specific clinical outcomes and biological features. A 10-gene RNA processing-related prognostic signature, involving ZBTB7A, METTL2B, CACTIN, TRUB2, POLDIP3, TSEN54, SUGP1, RBMS1, TGFB1, and PWP2, was further identified. The signature was a powerful and robust prognosis factor in both the training and validation datasets. Notably, it could stratify the survival of patients with GC in specific tumor-node-metastasis (TNM) classification subgroups. We constructed a composite prognostic nomogram to facilitate clinical practice by integrating this signature with other clinical variables (TNM stage, age). Patients with low-risk scores were characterized with good clinical outcomes, proliferation, and metabolism hallmarks. Conversely, poor clinical outcome, invasion, and metastasis hallmarks were enriched in the high-risk group. The RNA processing signature was also involved in tumor microenvironment reprogramming and regulating alternative splicing, causing different drug response features between the two risk groups. The low-risk subgroup was characterized by high genomic instability, high alternative splicing and might benefit from the immunotherapy. Our findings highlight the prognostic value of RNA processing factors for patients with GC and provide insights into the specific clinical and molecular features underlying the RNA processing-related signature, which may be important for patient management and targeting treatment.

show abstract

The prognostic value of preoperative fibrinogen-to-prealbumin ratio and a novel FFC score in patients with resectable gastric cancer

Cited by 24 publications

References 34 publications

Prealbumin to fibrinogen ratio is closely associated with diabetic peripheral neuropathy

Prealbumin to fibrinogen ratio is closely associated with diabetic peripheral neuropathy

The prognostic value of sarcopenia combined with preoperative fibrinogen–albumin ratio in patients with intrahepatic cholangiocarcinoma after surgery: A multicenter, prospective study

Comprehensive Characterization of RNA Processing Factors in Gastric Cancer Identifies a Prognostic Signature for Predicting Clinical Outcomes and Therapeutic Responses

Contact Info

Product

Resources

About