The prognostic value of neutrophil-to-lymphocyte ratio on mortality in critically ill trauma patients

Abstract

Prognostic study, level III.

Early Enteral Nutrition Adequacy Mitigates the Neutrophil–Lymphocyte Ratio Improving Clinical Outcomes in Critically Ill Surgical Patients

“…Venkatraghavan et al and Shimizu et al reported that preoperative higher NLR was significantly associated with increase of anesthesia risk in patients with heart diseases and mortality in patients with cancer . Dilektasli et al indicate that higher NLR during day 2 and day 5 after ICU admission is significantly associated with longer hospital LOS and mechanical ventilation support, and higher in‐hospital mortality . Our findings suggest that in critically ill surgical patients, higher NLR levels after days 3 and 5 of EN were associated with longer ICU LOS and increased CD and PD.…”

“…For example, Xue et al reported that higher NLR levels were associated with greater risk of stroke severity on admission, unfavorable outcomes, and recurrent acute ischemic stroke . In another study in critically ill trauma patients, high NLR levels on days 2 and 5 were significantly associated with longer hospital stay, longer ventilator‐free days, and higher in‐hospital mortality . However, neither study examined the relationship between NLR and nutrition adequacy.…”

“…Several studies have reported no association between NLR at baseline and clinical outcomes in critically ill patients. Dilektasli et al suggest that outcomes may be related to the ramping‐up of inflammatory response during the first 24 hours after injury . In contrast, Chua et al reported that lower NLR at baseline was associated with better clinical outcomes in older patients with advanced colorectal cancer .…”

“…The NLR has been added to the arsenal of prognostic biomarkers and has proven to be a useful objective indicator of inflammation in several diseases such as critical illness, malignancy, soft tissue sarcoma, trauma, diabetes mellitus, heart disease, and chronic kidney diseases . For example, Xue et al reported that higher NLR levels were associated with greater risk of stroke severity on admission, unfavorable outcomes, and recurrent acute ischemic stroke .…”

“…By dividing the absolute neutrophil count by the absolute lymphocyte count, the neutrophil–lymphocyte ratio (NLR) may be calculated. Recent investigations have confirmed the prognostic utility of the NLR in disease states such as cancer, heart disease, renal insufficiency, and critical illness …”