The Prognostic Value of NANO Scale Assessment in IDH-Wild-Type Glioblastoma Patients

Kasper, Johannes; Wende, Tim; Fehrenbach, Michael Karl; Wilhelmy, Florian; Jähne, Katja; Frydrychowicz, Clara; Prasse, Gordian; Meixensberger, Jürgen; Arlt, Felix

doi:10.3389/fonc.2021.790458

Cited by 4 publications

(3 citation statements)

References 30 publications

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“…These studies were heterogeneous, including patients with different diagnoses such as glioblastoma, low-grade glioma, meningioma, and neurological patients in general. The NANO scale has been employed in both prospective studies (13)(14)(15)(16)(17) and retrospective ones (18)(19)(20)(21)(22)(23). Despite the need for NANO validation with retrospective data, there appears to be no significant loss of clinical information.…”

Section: Discussionmentioning

confidence: 99%

Translation and validation of the Neurological Assessment in Neuro-Oncology scale to Brazilian Portuguese

Velho,

Andrade Gripp,

Pires de Aguiar

et al. 2024

Front. Neurol.

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IntroductionThe Neurological Assessment for Neuro-Oncology (NANO) scale was elaborated to assess neurologic function in integration with radiological criteria to evaluate neuro-oncological patients in clinical setting and enable the standardization of neurological assessment in clinical trials. The objective of this study is the translation to Brazilian Portuguese and transcultural adaptation of NANO scale in patients with the diagnosis of glioblastoma, brain metastasis and low-grade glioma.MethodsPatients with diagnosis of glioblastoma, brain metastasis, and low-grade glioma were prospectively evaluated between July 2019 and July 2021. The process of translating and cross-culturally adapting the NANO scale included: translation from English to Portuguese, synthesis and initial revision by an expert committee, back-translation from Portuguese to English, a second revision by the expert committee, and the application of the NANO scale. Regarding the reliability of the NANO scale, Cronbach’s alpha was employed to measure the internal consistency of all scale items and assess the impact of item deletion. Additionally, Spearman’s correlation test was used to evaluate the convergent validity between the NANO scale and Karnofsky Performance Scale (KPS).ResultsOne hundred and seventy-four patients were evaluated. A statistically significant inverse relation (p < 0.001) between KPS and NANO scale was founded. The Cronbach’s alpha values founded for NANO scale were 0.803 for glioblastoma, 0.643 for brain metastasis, and 0.482 for low grade glioma.DiscussionThe NANO scale Brazilian Portuguese version proves to be reproducible and valid to evaluate neuro-oncological patients with glioblastoma and brain metastasis, presenting a strong correlation with KPS scale. Further studies are warranted to assess the validity and reliability of the scale in patients diagnosed with low-grade glioma.

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Section: Discussionmentioning

confidence: 99%

Translation and validation of the Neurological Assessment in Neuro-Oncology scale to Brazilian Portuguese

Velho,

Andrade Gripp,

Pires de Aguiar

et al. 2024

Front. Neurol.

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“…The presented case illustrates our approach to steering through this intersection. It is crucial for every patient to be successful in this attempt, since both decreased neurological performance and decreased extent of resection are negative prognostic markers for survival time of patients with glioblastoma [15,16].…”

Section: Discussionmentioning

confidence: 99%

Usefulness and Limits of Tractography for Surgery in the Precentral Gyrus—A Case Report

Wende

Wilhelmy

Kasper

et al. 2022

Clinics and Practice

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The resection of tumors within the primary motor cortex is a constant challenge. Although tractography may help in preoperative planning, it has limited application. While it can give valuable information on subcortical fibers, it is less accurate in the cortical layer of the brain. A 38-year-old patient presented with paresis of the right hand and focal epileptic seizures due to a tumor in the left precentral gyrus. Transcranial magnetic stimulation was not applicable due to seizures, so microsurgical resection was performed with preoperative tractography and intraoperative direct electrical stimulation. A histopathological assessment revealed a diagnosis of glioblastoma. Postoperative magnetic resonance imaging (MRI) showed complete resection. The paresis dissolved completely during follow-up. Surgery within the precentral gyrus is of high risk and requires multimodal functional planning. If interpreted with vigilance and consciousness of the underlying physical premises, tractography can provide helpful information within its limitations, which is especially subcortically. However, it may also help in the identification of functional cortex columns of the brain in the presence of a tumor.

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“…Several clinical and radiological parameters were identified as being associated with survival prognosis. This includes the extent of resection (EOR), O6methylguanine DNA methyltransferase (MGMT) promoter methylation status [6], patient age at time of diagnosis [7], tumor location, or occurrence of neurological deficits [8,9].…”

Section: Introductionmentioning

confidence: 99%

Unplanned 30-Day Readmission in Glioblastoma Patients: Implications for the Extent of Resection and Adjuvant Therapy

Kasper,

Wach,

Vychopen

et al. 2023

Cancers

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Background: Unplanned early readmission (UER) within 30 days after hospital release is a negative prognostic marker for patients diagnosed with glioblastoma (GBM). This work analyzes the impact of UER on the effects of standard therapy modalities for GBM patients, including the extent of resection (EOR) and adjuvant therapy regimen. Methods: Records were searched for patients with newly diagnosed GBM between 2014 and 2020 who were treated at our facility. Exclusion criteria were being aged below 18 years or missing data. An overall survival (OS) analysis (Kaplan–Meier estimate; Cox regression) was performed on various GBM patient sub-cohorts. Results: A total of 276 patients were included in the study. UER occurred in 13.4% (n = 37) of all cases, significantly reduced median OS (5.7 vs. 14.5 months, p < 0.001 by logrank), and was associated with an increased hazard of mortality (hazard ratio 3.875, p < 0.001) in multivariate Cox regression when other clinical parameters were applied as confounders. The Kaplan–Meier analysis also showed that patients experiencing UER still benefitted from adjuvant radio-chemotherapy when compared to radiotherapy or no adjuvant therapy (p < 0.001 by logrank). A higher EOR did not improve OS in GBM patients with UER (p = 0.659). Conclusion: UER is negatively associated with survival in GBM patients. In contrast to EOR, adjuvant radio-chemotherapy was beneficial, even after UER.

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The Prognostic Value of NANO Scale Assessment in IDH-Wild-Type Glioblastoma Patients

Cited by 4 publications

References 30 publications

Translation and validation of the Neurological Assessment in Neuro-Oncology scale to Brazilian Portuguese

Translation and validation of the Neurological Assessment in Neuro-Oncology scale to Brazilian Portuguese

Usefulness and Limits of Tractography for Surgery in the Precentral Gyrus—A Case Report

Unplanned 30-Day Readmission in Glioblastoma Patients: Implications for the Extent of Resection and Adjuvant Therapy

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