The Prognostic Value of Left Atrial Deformation Parameters for Sudden Arrhythmic Events in Hypertrophic Cardiomyopathy

Zegkos, Thomas; Ntelios, Dimitrios; Parcharidou, Despοina; Katranas, Sotiris; Panagiotidis, Theofilos; Rouskas, Pavlos; Vassilikos, Vassilis; Karvounis, Haralampos; Efthimiadis, Georgios K.

doi:10.1016/j.echo.2020.05.013

Cited by 5 publications

(4 citation statements)

References 7 publications

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“…LA reservoir strain has been recently reported to confer increased risk for sudden arrhythmic events beyond the established algorithms for risk prediction. 33 Moreover, it has been associated with increased incidence of atrial fibrillation and heart failure outcomes independently of LA volume. 28 Considering the above findings and taking into account the association between LA myopathy and significant MR shown in this study, the presence of more than mild MR, irrespective of its mechanism, may itself represent a marker signifying increased morbidity and mortality in HCM patients.…”

Section: Discussionmentioning

confidence: 99%

“…The main clinical implication of the current study is that the identification of more than mild MR in patients with HCM warrants close follow up for LA myopathy, irrespective of the presence of LV outflow tract obstruction, underlying diastolic dysfunction or pulmonary pressures and more importantly, even in the absence of LA dilatation. LA reservoir strain has been recently reported to confer increased risk for sudden arrhythmic events beyond the established algorithms for risk prediction 33 . Moreover, it has been associated with increased incidence of atrial fibrillation and heart failure outcomes independently of LA volume 28 .…”

Section: Discussionmentioning

confidence: 99%

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Mitral regurgitation impact on left atrial myopathy in hypertrophic cardiomyopathy

et al. 2022

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Background: : Recent studies have shown that mitral regurgitation (MR) represents a major determinant of left atrial (LA) function in patients with heart failure with preserved ejection fraction. The role of MR in determining LA myopathy in hypertrophic cardiomyopathy (HCM) is unknown. The aim of this study was to examine the association of MR with LA myopathy, assessed by LA strain values in HCM patients. Methods: : In total 250 consecutive patients (mean age 51 ± 16 years, 67.2% male) with an established diagnosis of HCM and with sinus rhythm at index echocardiography evaluation were included. LA reservoir, conduit and booster strain were analyzed, besides LA size, left ventricular (LV) systolic and diastolic function. The predictors of LA strain values were identified with linear regression analysis.Results: : Significant (more than mild) MR was a significant univariate predictor of all the three LA strain values. In multivariate linear regression analysis, independent predictors of LA reservoir strain were more than mild MR (r = −.23), LV global longitudinal strain (r = −.49), LA volume index (r = −.27) and patient age (r = −.23). Significant MR was also an independent determinant of LA conduit (r = −.17) and booster strain (r = −.12). In patients with LA volume index < 34 ml/m 2 more than mild MR was an independent predictor of LA reservoir (r = −.32) and conduit strain (r = −.27), but not LA booster strain.Conclusion: : Significant MR is associated with LA myopathy independently of the LV diastolic and systolic function and LA size.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Mitral regurgitation impact on left atrial myopathy in hypertrophic cardiomyopathy

et al. 2022

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“…Finally, a correlation exists between LA and arrhythmic events. In fact, both LA size and function were associated with SCD, ventricular arrhythmias, and appropriate ICD discharge in independent studies [6,23,24]. In particular, the reduction of LA function as a reservoir (LA reservoir strain < 17%) displayed a significant additive predictive value on top of the HCM SCD risk score [24].…”

Section: La Size and Functionmentioning

confidence: 98%

“…However, abnormalities in regional systolic function can be identified at earlier stages, in which LVEF is preserved but fibrosis starts to accumulate, if alternative imaging modalities are used. Reduced systolic strain assessed by speckle tracking echocardiography identifies patients with more severe disease manifestation [31,32] and an increased risk for major cardiac events [23,33]. Specifically, in a study by Haland et al [32], mechanical dispersion (calculated as the standard deviation of time from the beginning of the QRS complex on electrocardiogram to peak longitudinal strain in 16 LV segments) was a strong independent risk predictor of ventricular arrhythmias and related to the extent of fibrosis at CMR, improving risk stratification when added to the conventional SCD score.…”

Section: Systolic and Diastolic Functionmentioning

confidence: 99%

Echocardiographic predictors of outcomes in hypertrophic cardiomyopathy

Franco,

Pálinkás,

Panichella

et al. 2023

Explor Cardiol

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The use of echocardiography, a straightforward and widely available technique, allows for a comprehensive assessment of the patient with hypertrophic cardiomyopathy (HCM) under both resting and stress conditions. The true prevalence of HCM has been redefined over time by this imaging approach, which has also made it feasible to pinpoint parameters that clinicians may use to stratify patients at risk for adverse cardiovascular events. The current and emerging prognostic predictors in HCM, assessed with transthoracic echocardiography at rest and during provocation, are discussed in this review.

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Prognostic Relevance of a Score for Identifying Diastolic Dysfunction according to the 2016 American Society of Echocardiography/European Association of Cardiovascular Imaging Recommendations in Patients with Hypertrophic Cardiomyopathy

Saito

Minami

Haruki

et al. 2022

Journal of the American Society of Echocardiography

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The Prognostic Value of Left Atrial Deformation Parameters for Sudden Arrhythmic Events in Hypertrophic Cardiomyopathy

Cited by 5 publications

References 7 publications

Mitral regurgitation impact on left atrial myopathy in hypertrophic cardiomyopathy

Mitral regurgitation impact on left atrial myopathy in hypertrophic cardiomyopathy

Echocardiographic predictors of outcomes in hypertrophic cardiomyopathy

Prognostic Relevance of a Score for Identifying Diastolic Dysfunction according to the 2016 American Society of Echocardiography/European Association of Cardiovascular Imaging Recommendations in Patients with Hypertrophic Cardiomyopathy

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