The prognostic value of gender in gastric gastrointestinal stromal tumors: A propensity score matching analysis.

Abstract

Background: Gastrointestinal stromal tumors (GISTs) of the stomach are the most common GISTs. The risk, incidence and outcome of cancer are different between the sexes. Whether gender is related to the prognosis of gastric stromal tumors is unclear. Therefore, this study aims to explore the relationship between gender and gastric GIST prognosis.Methods: Data from gastric GIST patients were collected from the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM) was performed to reduce confounding factors, and the clinicopathological features and prognosis of GIST patients were comprehensively evaluated.Results: There were 512 male patients and 538 female patients with gastric GIST. The gender of gastric GIST patients was associated with marital status, surgical treatment, tumor size, and mitotic index (P < 0.05). The Kaplan-Meier analysis and log-rank test revealed that male patients had a higher mortality rate than female patients (P = 0.0024). After matching all the potential confounding factors, the survival of the female gastric GIST patients was better than that of the male gastric GIST patients (P = 0.042). Cox regression analysis revealed that gender was an independent risk factor for overall survival. The risk of death was higher for males than for females (HR: 1.677, 95% CI: 1.150-2.444, P = 0.007). Conclusion: Gender could be a prognostic factor for gastric GIST survival, and male patients had a higher risk of death.

Current treatment and outcomes of pediatric gastrointestinal stromal tumors (GIST): a systematic review of published studies

“…Gastric GIST accounts for approximately 50% of all cases encountered in the general population [7,12,16] whereas the vast majority of pediatric GIST tumors (> 80%) are located in the stomach as reported here and by Benesch et al [18]. Previously, male sex [2,19] and non-gastric location [2] have been identified as adverse prognostic factors in GIST. However, with female preponderance and a higher proportion of gastric tumors observed compared to the adult populations this may explain in part the better outcomes recorded in pediatric patients.…”

The Number of Positive Tumor Markers (NPTM) Achieves Higher Value in the Prognosis Prediction of Gastric Cancer

“…However, the survival of GC patients at the same disease stage might be heterogeneous [5]. Many other factors such as age, gender, tumor size, tumor location, inflammatory factors, and tumor markers not involved in AJCC staging system might affect the outcomes of GC as well [6][7][8][9][10]. Thus, by integrating these important factors, the individual prognosis of GC patients could be better assessed.…”