The Prognostic Value of Creatine Kinase-MB Dynamics after Primary Angioplasty in ST-Elevation Myocardial Infarctions

Abstract

Background: In STEMIs, the evaluation of the relationship between biomarkers of myocardial injury and patients’ prognoses has not been completely explored. Increased levels of CK-MB in patients with a STEMI undergoing primary angioplasty are known to be associated with higher mortality rates, yet the correlation of these values with short-term evolution remains unknown. Material and Methods: The research encompassed a sample of 80 patients diagnosed with STEMIs, and its methodology entailed a retrospective analysis of the data collected during their hospital stays. The study population was then categorized into three distinct analysis groups based on the occurrence or absence of acute complications and fatalities. Results: The findings indicated that there is a notable correlation between rising levels of CK-MB upon admission and peak CK-MB levels with a reduction in left ventricular ejection fraction. Moreover, the CK-MB variation established a point of reference for anticipating complications at 388 U/L, and a cut-off value for predicting death at 354 U/L. Conclusion: CK-MB values are reliable indicators of the progress of patients with STEMIs. Furthermore, the difference between the peak and admission CK-MB levels demonstrates a high accuracy of predicting complications and has a significant predictive power to estimate mortality risk.

Assessing cardiac function post chemotherapy combined with immune checkpoint inhibitors via automated two-dimensional speckle tracking

“…In this study, creatine kinase, CK-MB, and lactate dehydrogenase isoenzyme increased in the sixth month of follow-up. CK and CK-MB can be used for the early diagnosis of myocardial injury after MI because of their high sensitivity, and dynamic monitoring activity can be used to determine changes in the disease 21 . LDH and creatine kinase isoenzymes were used as cardiac injury biomarkers to assess catalpol treatment in mice with doxorubicin-induced cardiotoxicity 22 .…”