The Prognostic Value of Cancer Stem Cell Markers in Cervical Cancer: A Systematic Review and Meta-Analysis

Fahmi, Moh Nailul; Hertapanndika, Inge Nandya; Kusuma, Fitriyadi

doi:10.31557/apjcp.2021.22.12.4057

Cited by 10 publications

(9 citation statements)

References 37 publications

(51 reference statements)

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“…CD44 expression in cancer has been correlated with both poor and favourable outcomes [49]; however, growing evidence now suggests that overexpression of CD44 and its isoforms is an unfavourable prognostic indicator in cancer patients [50][51][52][53][54][55][56][57][58][59][60][61]. A list of some of these studies, although not comprehensive, is provided in Table 1.…”

Section: Expression Of Cd44 As a Prognostic Biomarkermentioning

confidence: 99%

The Hyaluronan/CD44 Axis: A Double-Edged Sword in Cancer

Cirillo

2023

IJMS

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Hyaluronic acid (HA) receptor CD44 is widely used for identifying cancer stem cells and its activation promotes stemness. Recent evidence shows that overexpression of CD44 is associated with poor prognosis in most human cancers and mediates therapy resistance. For these reasons, in recent years, CD44 has become a treatment target in precision oncology, often via HA-conjugated antineoplastic drugs. Importantly, HA molecules of different sizes have a dual effect and, therefore, may enhance or attenuate the CD44-mediated signaling pathways, as they compete with endogenous HA for binding to the receptors. The magnitude of these effects could be crucial for cancer progression, as well as for driving the inflammatory response in the tumor microenvironment. The increasingly common use of HA-conjugated drugs in oncology, as well as HA-based compounds as adjuvants in cancer treatment, adds further complexity to the understanding of the net effect of hyaluronan-CD44 activation in cancers. In this review, I focus on the significance of CD44 in malignancy and discuss the dichotomous function of the hyaluronan/CD44 axis in cancer progression.

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Section: Expression Of Cd44 As a Prognostic Biomarkermentioning

confidence: 99%

The Hyaluronan/CD44 Axis: A Double-Edged Sword in Cancer

Cirillo

2023

IJMS

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“…Importantly, studies conducted on the HeLa cell line showed that natural polyphenols such as karanjin, plumbagin, and pongapin, which affect the inhibition of cell proliferation and induce apoptosis, also have the ability to attenuate the expression of the HA-CD44 pathway [55]. The important role of HA in the course of cancer is indicated by a meta-analysis of 22 studies from electronic databases involving more than 2200 patients with CC [82]. In the studied group of women, a correlation was determined between the expression levels of seven important CSC markers, including the CD44 protein, and clinical parameters DFS and OS [82].…”

Section: Cervical Cancermentioning

confidence: 99%

“…The important role of HA in the course of cancer is indicated by a meta-analysis of 22 studies from electronic databases involving more than 2200 patients with CC [82]. In the studied group of women, a correlation was determined between the expression levels of seven important CSC markers, including the CD44 protein, and clinical parameters DFS and OS [82]. Specifically, it was shown that overexpression of CD44, a major cell surface receptor for hyaluronan, was significantly associated with worse OS (HR 1.14, 95% CI 1.07-1.22, p = 0.0001) [82], suggesting that this marker could be used as a prognostic indicator of adverse survival among CC patients.…”

Section: Cervical Cancermentioning

confidence: 99%

“…In the studied group of women, a correlation was determined between the expression levels of seven important CSC markers, including the CD44 protein, and clinical parameters DFS and OS [82]. Specifically, it was shown that overexpression of CD44, a major cell surface receptor for hyaluronan, was significantly associated with worse OS (HR 1.14, 95% CI 1.07-1.22, p = 0.0001) [82], suggesting that this marker could be used as a prognostic indicator of adverse survival among CC patients. In a study conducted by Zhang et al [56], aimed at determining the role of HABP1 and its association with clinical features among CC patients, the overexpression of this protein was found to correlate with advanced FIGO stage (p = 0.…”

Section: Cervical Cancermentioning

confidence: 99%

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Role of Hyaluronic Acid in Selected Malignant Neoplasms in Women

et al. 2023

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Hyaluronic acid (HA) is a significant glycosaminoglycan component of the extracellular matrix, playing an essential role in cell localization and proliferation. However, high levels of HA may also correlate with multidrug resistance of tumor cells, an increased tendency to metastasize, or cancer progression, and thus represent a very unfavorable prognosis for cancer patients. The purpose of this review article is to summarize the results of studies describing the relationship between HA, the main ligand of the CD44 receptor, or other components of the HA signaling pathway. In addition, we review the course of selected female malignancies, i.e., breast, cervical, endometrial, and ovarian cancer, with the main focus on the mechanisms oriented to CD44. We also analyze reports on the beneficial use of HA-containing preparations in adjuvant therapy among patients with these types of cancer. Data from the literature suggest that HA and its family members may be critical prognostic biomarkers of selected malignancies among women. Nevertheless, the results of the available studies are inconclusive, and the actual clinical significance of HA expression analysis is still quite enigmatic. In our opinion, the HA-CD44 signaling pathway should be an attractive target for future research related to targeted therapy in gynecological cancers.

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“…Treatment of advanced cervical cancer includes surgery, chemotherapy, and radiation therapy, but cervical cancer mortality remains high ( 141 ), mainly related to CSCs ( 142 ). Studies have suggested that ALDH1 can be used as a cervical CSC marker ( 143 , 144 ), which can lead to resistance to chemotherapy and is closely related to a poor prognosis ( 145 ).…”

Section: Aldh1 and Various Solid Tumorsmentioning

confidence: 99%

ALDH1: A potential therapeutic target for cancer stem cells in solid tumors

Wei

Chen

et al. 2022

Front. Oncol.

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Solid tumors can be divided into benign solid tumors and solid malignant tumors in the academic community, among which malignant solid tumors are called cancers. Cancer is the second leading cause of death in the world, and the global incidence of cancer is increasing yearly New cancer patients in China are always the first. After the concept of stem cells was introduced in the tumor community, the CSC markers represented by ALDH1 have been widely studied due to their strong CSC cell characteristics and potential to be the driving force of tumor metastasis. In the research results in the past five years, it has been found that ALDH1 is highly expressed in various solid cancers such as breast cancer, lung cancer, colorectal cancer, liver cancer, gastric cancer, cervical cancer, esophageal cancer, ovarian cancer, head,and neck cancer. ALDH1 can activate and transform various pathways (such as the USP28/MYC signaling pathway, ALDH1A1/HIF-1α/VEGF axis, wnt/β-catenin signaling pathway), as well as change the intracellular pH value to promote formation and maintenance, resulting in drug resistance in tumors. By targeting and inhibiting ALDH1 in tumor stem cells, it can enhance the sensitivity of drugs and inhibit the proliferation, differentiation, and metastasis of solid tumor stem cells to some extent. This review discusses the relationship and pathway of ALDH1 with various solid tumors. It proposes that ALDH1 may serve as a diagnosis and therapeutic target for CSC, providing new insights and new strategies for reliable tumor treatment.

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The Prognostic Value of Cancer Stem Cell Markers in Cervical Cancer: A Systematic Review and Meta-Analysis

Cited by 10 publications

References 37 publications

The Hyaluronan/CD44 Axis: A Double-Edged Sword in Cancer

The Hyaluronan/CD44 Axis: A Double-Edged Sword in Cancer

Role of Hyaluronic Acid in Selected Malignant Neoplasms in Women

ALDH1: A potential therapeutic target for cancer stem cells in solid tumors

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