The prognostic value of 18F-fluorodeoxyglucose positron emission tomography/ computed tomography parameters in patients with malignant pleural mesothelioma

Abstract

Background In this study, we aimed to investigate the prognostic value of metabolic 18 F-fluorodeoxyglucose positron emission tomography/computed tomography parameters in malignant pleural mesothelioma patients. Methods A total of 65 patients with malignant pleural mesothelioma (34 males, 31 females; median age: 60 years; range, 39 to 84 years) who underwent whole-body 18 F-fluorodeoxyglucose positron emission tomography/computed tomography for staging before treatment between March 2008 and January 2018 were included. Relationships between clinicopathological factors and 18 F-fluorodeoxyglucose positron emission tomography/computed tomography parameters and overall survival were evaluated using a log-rank test and Cox regression analysis. Results The median follow-up was 13 (range, 4 to 55) months. The Kaplan-Meier analysis revealed a mean survival time of 17±2.6 months. The cumulative two- and five-year survival rates were 34.8% and 7.8%, respectively. Univariate analysis showed that ≥60 age, left hemithorax involvement, a maximum standardized uptake value of ≥9.8, c-T4 status, c-M1 status, and non-surgery were negatively associated with overall survival (p<0.05). Multivariate analysis showed that ≥60 age, left hemithorax involvement, a maximum standardized uptake value of ≥9.8, c-M1 status, and a total lesion glycolysis of ≥180.2 g were negatively associated with overall survival (p<0.05). Conclusion Metabolic parameters of 18 F-fluorodeoxyglucose positron emission tomography/computed tomography have the potential to provide prognostic information for malignant pleural mesothelioma patients who are receiving surgery and/or chemotherapy.

Prognostic value of maximum standard uptake value, metabolic tumour volume, and total lesion glycolysis of 18F-FDG PET/CT in patients with malignant pleural mesothelioma: a systematic review and meta-analysis

“…Finally, 12 articles involving 1307 cases, which conformed to our pre-set selection criteria, were included in the current analysis. The enrolled articles were published between 2006 and 2021 [ 22 , 23 , 25 , 28 – 36 ] (Fig. 1 ).…”

“…Nonetheless, MPM survival prediction using the 18F-FDG PET/CT parameters is debatable.Some reports suggest that the increased SUVmax is related to the dismal survival of MPM cases [ 22 – 24 ], where as Doi et al [ 25 ] did not observe such relationships. Hence, through the current meta-analysis, we aimed to evaluate the significance of SUVmax, TLG, and MTV in predicting MPM survival.…”

Prognostic factors and the prognostic role of inflammation indices in malignant pleural mesothelioma

“…[12] Some studies have reported that fluorodeoxyglucose positron emission tomography (PET)-computed tomography (CT) parameters may also play a prognostic role in mesothelioma. [13] This may also be an indirect indicator of inflammation.…”