The Prognostic Superiority of Log Odds of Positive Lymph Nodes in Stage III Colon Cancer

Wang, Jiping; Hassett, James M.; Dayton, Merril T.; Kulaylat, Mahmoud N.

doi:10.1007/s11605-008-0651-3

Cited by 110 publications

(130 citation statements)

References 26 publications

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“…The results highlight the prognostic World J Surg (2012) 36:1906-1914 1911 role and value of lymph node evaluation in four perspectives, described in the paragraphs that follow. First, through a correlation study among these five types of evaluation, we noted that LNN highly correlated with LNT, and that LODDS highly correlated with LNR, findings consistent with a prior report from Wang et al [17]. In that study, they observed a marked association between LNT and LNN.…”

Section: Discussionsupporting

confidence: 91%

“…Also, some investigators have reported that various types of lymph node evaluation besides the total number of lymph nodes retrieved (LNT) can effectively predict long-term outcome, including number of negative lymph nodes (LNN) [4], number of positive lymph nodes (LNP) [13][14][15], ratio of positive lymph nodes (LNR) [2,11,12,16], and log odds of positive lymph nodes (LODDS) [17]. In the meantime, investigators discovered cut-off values other than the benchmark number that could have good prognostic value [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of Lymph Nodes in Patients with Colon Cancer Undergoing Colon Resection: A Population‐based Study

Chang

Chen

et al. 2012

World j. surg.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Evaluation of Lymph Nodes in Patients with Colon Cancer Undergoing Colon Resection: A Population‐based Study

Chang

Chen

et al. 2012

World j. surg.

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“…LODDS, a novel indicator of predicting lymph node status, may provide a new means for improving the accuracy of N classification for prognostic assessment. Previous studies have indicated the superiority of LODDS over LNR in terms of prognostic significance in colon cancer (17,23,24). However, the available data remain limited.…”

Section: Discussionmentioning

confidence: 99%

“…The log odds of positive lymph nodes (LODDS), another novel prognostic indicator, was recently introduced (17) and it is defined as the log of the ratio between the number of positive and the number of negative lymph nodes. The prognostic significance of LODDS in gastric, pancreatic and breast cancer was previously investigated (18)(19)(20)(21)(22) and certain studies have indicated the superiority of LODDS over LNR in terms of prognostic significance in Log odds of positive lymph nodes is superior to the numberand ratio-based lymph node classification systems for colorectal cancer patients undergoing curative (R0) resection (17,23,24). The value of LODDS remains unclear, and studies comparing the prognostic value among the pN, LNR and LODDS classifications for CRC following R0 resection have been sparse.…”

Section: Introductionmentioning

confidence: 99%

Log odds of positive lymph nodes is superior to the number- and ratio-based lymph node classification systems for colorectal cancer patients undergoing curative (R0) resection

Fang

Yang

et al. 2017

Molecular and Clinical Oncology

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Abstract. The metastatic lymph node status (N classification) is an important prognostic factor for patients with colorectal cancer (CRC). The aim of the present study was to evaluate and compare the prognostic assessment of three different lymph node staging methods, namely standard lymph node (pN) staging, metastatic lymph node ratio (LNR) and log odds of positive lymph nodes (LODDS) in CRC patients who undergo curative resection (R0). Data were retrospectively collected from 192 patients who had undergone R0 resection. Kaplan-Meier survival curves, Cox proportional hazards model and accuracy of the three methods (pN, LNR and LODDS) were compared to evaluate the prognostic effect. Univariate analysis demonstrated that pN, LNR and LODDS were all significantly correlated with survival (P=0.001, P<0.001 and P<0.001, respectively). The final result of the 3-step multivariate analysis demonstrated that LODDS was superior to the other two N categories. Patients in the same pN or LNR classifications may be classified into different LODDS stages with different prognoses. Thus, LODDS may be a meaningful prognostic indicator and superior to the pN and LNR classifications in CRC patients who undergo curative (R0) resection.

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“…The log odds of positive lymph nodes (LODDS) have been regarded a novel prognostic indicator in many other cancers, such as pancreatic cancer, gastric cancer, and colorectal cancer, defined as the log of the ratio between the probability of being a positive LN and the probability of being a negative LN when one LN is dissected (9)(10)(11)(12)(13)(14). However, in dealing with advanced ESCC patients (pN0 stage especially) after curative surgery, rare attention has been paid to the prognostic value of LODDS.…”

Section: Introductionmentioning

confidence: 99%

Log odds of positive lymph nodes is a novel prognostic indicator for advanced ESCC after surgical resection

Yang

Zhang

et al. 2017

J. Thorac. Dis.

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Background: To investigate the prognostic value of the log odds of positive lymph nodes (LODDS) in patients with advanced esophageal squamous cell carcinoma (ESCC) after surgical resection. Methods: Clinical data of 260 patients with advanced ESCC undergoing surgical resection were retrospectively reviewed. Univariate and multivariate analysis were done using the chi-square test and Cox regression model. Receiver-operating-characteristic (ROC) curve was used to compare the association of pathologic nodal (pN) and LODDS with 3-or 5-year overall survival (OS). The cut-point analyses were performed to determine whether there was a cutoff LODDS related to the greatest OS difference. Results: The mean follow-up duration was 30 months (range, 3 to 106 months). The 1-, 3-, 5-year OS rates were 70.0%, 41.9% and 30.3%, respectively. Univariate analyses indicated that the 5-year OS rates were 51.2%, 30.5%, 24.6%, and 14.2% in LODDS1, LODDS2, LODDS3, and LODDS4, respectively, and the median survival times were 68.7, 34.6, 24.0, and 14.6 months, respectively (P=0.000) for all patients, and subgroup analysis showed the effect did not change in 155 patients without lymph node (LN) metastasis (P=0.024). Multivariate analysis showed that LODDS [hazard ratio (HR) =1.309, P=0.003] to be independent and significant prognostic factors for all patients, so as in node-negative patients LODDS (HR =1.610, P=0.038). The AUC of LODDS stage (AUC =0.630) was larger than that of pN stage (AUC =0.621) in prediction of 3-year OS, however LODDS were smaller in prediction of 5-year OS (AUC =0.620, 0.631, respectively), and the differences were not statistically significant (P>0.05 all). Lastly, the step analysis identified the best cut-off point for LODDS as −1.2 that is significantly associated with the prognosis of the node-negative patients (P=0.024), and the ROC analysis also indicated that a cut-off value of −1.2 for LODDS provided the highest sensitivity and specificity interestingly.Conclusions: LODDS may be suitable for evaluation of OS in advanced ESCC patients without LN metastasis.

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The Prognostic Superiority of Log Odds of Positive Lymph Nodes in Stage III Colon Cancer

Abstract: Colon cancer patients with LNR4 disease represent a heterogeneous group. The previously reported prognostic association of TNODS and LNR and outcome of stage III disease were confounded by LODDS.

Cited by 110 publications

References 26 publications

Evaluation of Lymph Nodes in Patients with Colon Cancer Undergoing Colon Resection: A Population‐based Study

Evaluation of Lymph Nodes in Patients with Colon Cancer Undergoing Colon Resection: A Population‐based Study

Log odds of positive lymph nodes is superior to the number- and ratio-based lymph node classification systems for colorectal cancer patients undergoing curative (R0) resection

Log odds of positive lymph nodes is a novel prognostic indicator for advanced ESCC after surgical resection

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