The prognostic significance of surgical staging for carcinoma of the endometrium

Salvage Versus Adjuvant Radiation Treatment for Women With Early-Stage Endometrial Carcinoma

“…5 The potential importance of this was highlighted in several publications where the error in clinical staging compared with surgical staging varied from 12% to 59% of patients depending on the subset of patients. 37,38 CONCLUSIONS In women with early-stage EC, our study suggests that women who receive SRT for their locoregional recurrence have worse DSS and OS compared with those matched patients who received ART. Additional investigation is warranted to develop a high-quality cost-effectiveness analysis as well as accurate predictive models of tumor recurrence.…”

Do We Know the Best Therapy for Early Endometrial Cancer?

“…Pelvic control was achieved in 67% of these patients. When there was only analysis of women with endometrial cancer demonstrated a 25% error in clinical staging compared to surgical staging vaginal mucosal involvement, pelvic control was achieved in 79% of patients compared to 43% when there was mucosal [4]. Patients with clinical stage I disease were found to have more advanced disease in 12% of cases, while 59% of paand pelvic involvement.…”

Survival and Disease Relapse in Surgical Stage I Endometrioid Adenocarcinoma of the Uterus After Adjuvant Vaginal Vault Brachytherapy

“…Five-year survival for stage I endometrioid adenocarcinoma of the uterus is nearly 91% and varies depending on DMI, tumor size, site, grade, LVSI, and age. 7 A prospective randomized trial by the Gynecologic Oncology Group established that adjuvant pelvic radiation in high-risk nodes-negative endometrial adenocarcinoma reduces the risk of local and distant failures and improves survival. 6 Rittenberg et al 9 concluded that VVBT is equally effective, with significantly less patient morbidity.…”

“…5,6 Whereas deep invasion of the myometrium is a significant, independent, poor prognostic factor, others such as advanced age, moderately or poorly differentiated tumors, isthmic-cervical extension, and lymphvascular space invasion (LVSI) also increase the risk of recurrence in stage I endometrioid adenocarcinoma. 1,2,5,7 Because recurrence is associated with poor survival, postoperative treatment is aimed at decreasing the risk of relapse and optimizing cure and survival in high-risk patients. 1 Adjuvant therapy in high-risk patients with surgical stage I endometrioid adenocarcinoma of the uterus lacks consensus and has a variety of treatment plans.…”