The prognostic significance of subclinical hepatic encephalopathy

Hartmann, Ieneke J. C.; Groeneweg, Michael; Quero, Juan C.; Beijeman, Sylvia J; Man, Robert A. de; Hop, Wim C. J.; Schalm, Solko W.

doi:10.1111/j.1572-0241.2000.02265.x

Cited by 196 publications

(65 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar results had been achieved years before by Hartmann et al [26]. They studied 116 patients of whom 25 were diagnosed with mHE using the NCTA, digit symbol test and EEG.…”

Section: Prognosissupporting

confidence: 63%

The Clinical Relevance of Minimal Hepatic Encephalopathy - A Critical Look

Weißenborn¹

2015

Dig Dis

View full text Add to dashboard Cite

Minimal hepatic encephalopathy (mHE) is diagnosed in patients with severe liver disease but no clinical symptoms of encephalopathy if either neuropsychological or neurophysiological tests indicate cerebral dysfunction and other possible causes of brain dysfunction have been excluded. mHE is characterized by deficits in attention, visuospatial orientation, visuoconstructive abilities and motor function. Accordingly, mHE can be expected to interfere with a subject's working ability, especially in those occupations that require handiwork, and driving ability. Indeed, about 60% of blue-collar workers with mHE have been shown to be assessed as unfit for work compared to only 20% of white-collar workers, and about 50% of patients with mHE have been judged unfit to drive a car in several studies. mHE interferes with a patient's quality of life and is associated with an increased risk of developing overt HE as well as increased mortality. Whether mHE is of importance for cognitive function after liver transplantation has still to be clarified.

show abstract

“…Similar results had been achieved years before by Hartmann et al [26]. They studied 116 patients of whom 25 were diagnosed with mHE using the NCTA, digit symbol test and EEG.…”

Section: Prognosissupporting

confidence: 63%

The Clinical Relevance of Minimal Hepatic Encephalopathy - A Critical Look

Weißenborn¹

2015

Dig Dis

View full text Add to dashboard Cite

show abstract

“…In three recent studies [15,17,18], MHE in combination with liver dysfunction was related to the development of overt HE in long-term follow-up. MHE had been diagnosed using a combination of three psychometric tests that had proved useful in previous reports [19].…”

Section: Discussionmentioning

confidence: 96%

Intestinal glutaminase activity is increased in liver cirrhosis and correlates with minimal hepatic encephalopathy

Romero‐Gómez

Ramos-Guerrero

Grande

et al. 2004

Journal of Hepatology

View full text Add to dashboard Cite

“…However, its prognostic value has been demonstrated in many other situations involving cirrhosis over the last 30 years. In particular, multivariate analyses using Child-Pugh score as an entity have shown that it has an independent prognostic value in the settings of ascites [13], ruptured oesophageal varices [14], subclinical encephalopathy [15], hepatocellular carcinoma [16], liver surgery [17], alcoholic cirrhosis [18], decompensated HCV-related cirrhosis [19], primary sclerosing cholangitis [20], primary biliary cirrhosis [21] and Budd-Chiari syndrome [22].…”

Section: Validationmentioning

confidence: 99%